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Vitamin D supplementation and COVID-19 risk: a population-based, cohort study

PURPOSE: To analyze the associations between cholecalciferol or calcifediol supplementation, serum 25-hydroxyvitamin D (25OHD) levels and COVID-19 outcomes in a large population. METHODS: All individuals ≥ 18 years old living in Barcelona-Central Catalonia (n = 4.6 million) supplemented with choleca...

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Autores principales: Oristrell, J., Oliva, J. C., Casado, E., Subirana, I., Domínguez, D., Toloba, A., Balado, A., Grau, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285728/
https://www.ncbi.nlm.nih.gov/pubmed/34273098
http://dx.doi.org/10.1007/s40618-021-01639-9
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author Oristrell, J.
Oliva, J. C.
Casado, E.
Subirana, I.
Domínguez, D.
Toloba, A.
Balado, A.
Grau, M.
author_facet Oristrell, J.
Oliva, J. C.
Casado, E.
Subirana, I.
Domínguez, D.
Toloba, A.
Balado, A.
Grau, M.
author_sort Oristrell, J.
collection PubMed
description PURPOSE: To analyze the associations between cholecalciferol or calcifediol supplementation, serum 25-hydroxyvitamin D (25OHD) levels and COVID-19 outcomes in a large population. METHODS: All individuals ≥ 18 years old living in Barcelona-Central Catalonia (n = 4.6 million) supplemented with cholecalciferol or calcifediol from April 2019 to February 2020 were compared with propensity score-matched untreated controls. Outcome variables were SARS-CoV2 infection, severe COVID-19 and COVID-19 mortality occuring during the first wave of the pandemic. Demographical data, comorbidities, serum 25OHD levels and concomitant pharmacological treatments were collected as covariates. Associations between cholecalciferol or calcifediol use and outcome variables were analyzed using multivariate Cox proportional regression. RESULTS: Cholecalciferol supplementation (n = 108,343) was associated with slight protection from SARS-CoV2 infection (n = 4352 [4.0%] vs 9142/216,686 [4.2%] in controls; HR 0.95 [CI 95% 0.91–0.98], p = 0.004). Patients on cholecalciferol treatment achieving 25OHD levels ≥ 30 ng/ml had lower risk of SARS-CoV2 infection, lower risk of severe COVID-19 and lower COVID-19 mortality than unsupplemented 25OHD-deficient patients (56/9474 [0.6%] vs 96/7616 [1.3%]; HR 0.66 [CI 95% 0.46–0.93], p = 0.018). Calcifediol use (n = 134,703) was not associated with reduced risk of SARS-CoV2 infection or mortality in the whole cohort. However, patients on calcifediol treatment achieving serum 25OHD levels ≥ 30 ng/ml also had lower risk of SARS-CoV2 infection, lower risk of severe COVID-19, and lower COVID-19 mortality compared to 25OHD-deficient patients not receiving vitamin D supplements (88/16276 [0.5%] vs 96/7616 [1.3%]; HR 0.56 [CI 95% 0.42–0.76], p < 0.001). CONCLUSIONS: In this large, population-based study, we observed that patients supplemented with cholecalciferol or calcifediol achieving serum 25OHD levels ≥ 30 ng/ml were associated with better COVID-19 outcomes. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40618-021-01639-9.
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spelling pubmed-82857282021-07-19 Vitamin D supplementation and COVID-19 risk: a population-based, cohort study Oristrell, J. Oliva, J. C. Casado, E. Subirana, I. Domínguez, D. Toloba, A. Balado, A. Grau, M. J Endocrinol Invest Original Article PURPOSE: To analyze the associations between cholecalciferol or calcifediol supplementation, serum 25-hydroxyvitamin D (25OHD) levels and COVID-19 outcomes in a large population. METHODS: All individuals ≥ 18 years old living in Barcelona-Central Catalonia (n = 4.6 million) supplemented with cholecalciferol or calcifediol from April 2019 to February 2020 were compared with propensity score-matched untreated controls. Outcome variables were SARS-CoV2 infection, severe COVID-19 and COVID-19 mortality occuring during the first wave of the pandemic. Demographical data, comorbidities, serum 25OHD levels and concomitant pharmacological treatments were collected as covariates. Associations between cholecalciferol or calcifediol use and outcome variables were analyzed using multivariate Cox proportional regression. RESULTS: Cholecalciferol supplementation (n = 108,343) was associated with slight protection from SARS-CoV2 infection (n = 4352 [4.0%] vs 9142/216,686 [4.2%] in controls; HR 0.95 [CI 95% 0.91–0.98], p = 0.004). Patients on cholecalciferol treatment achieving 25OHD levels ≥ 30 ng/ml had lower risk of SARS-CoV2 infection, lower risk of severe COVID-19 and lower COVID-19 mortality than unsupplemented 25OHD-deficient patients (56/9474 [0.6%] vs 96/7616 [1.3%]; HR 0.66 [CI 95% 0.46–0.93], p = 0.018). Calcifediol use (n = 134,703) was not associated with reduced risk of SARS-CoV2 infection or mortality in the whole cohort. However, patients on calcifediol treatment achieving serum 25OHD levels ≥ 30 ng/ml also had lower risk of SARS-CoV2 infection, lower risk of severe COVID-19, and lower COVID-19 mortality compared to 25OHD-deficient patients not receiving vitamin D supplements (88/16276 [0.5%] vs 96/7616 [1.3%]; HR 0.56 [CI 95% 0.42–0.76], p < 0.001). CONCLUSIONS: In this large, population-based study, we observed that patients supplemented with cholecalciferol or calcifediol achieving serum 25OHD levels ≥ 30 ng/ml were associated with better COVID-19 outcomes. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40618-021-01639-9. Springer International Publishing 2021-07-17 2022 /pmc/articles/PMC8285728/ /pubmed/34273098 http://dx.doi.org/10.1007/s40618-021-01639-9 Text en © Italian Society of Endocrinology (SIE) 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Article
Oristrell, J.
Oliva, J. C.
Casado, E.
Subirana, I.
Domínguez, D.
Toloba, A.
Balado, A.
Grau, M.
Vitamin D supplementation and COVID-19 risk: a population-based, cohort study
title Vitamin D supplementation and COVID-19 risk: a population-based, cohort study
title_full Vitamin D supplementation and COVID-19 risk: a population-based, cohort study
title_fullStr Vitamin D supplementation and COVID-19 risk: a population-based, cohort study
title_full_unstemmed Vitamin D supplementation and COVID-19 risk: a population-based, cohort study
title_short Vitamin D supplementation and COVID-19 risk: a population-based, cohort study
title_sort vitamin d supplementation and covid-19 risk: a population-based, cohort study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285728/
https://www.ncbi.nlm.nih.gov/pubmed/34273098
http://dx.doi.org/10.1007/s40618-021-01639-9
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