Cargando…
Calcium channel blockers do not protect against saturated fatty acid-induced ER stress and apoptosis in human pancreatic β-cells
It was evidenced that saturated fatty acids (FAs) have a detrimental effect on pancreatic β-cells function and survival, leading to endoplasmic reticulum (ER) calcium release, ER stress, and apoptosis. In the present study, we have tested the effect of three calcium influx inhibitors, i.e., diazoxid...
Autores principales: | Šrámek, Jan, Němcová, Vlasta, Kovář, Jan |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285784/ https://www.ncbi.nlm.nih.gov/pubmed/34274001 http://dx.doi.org/10.1186/s12986-021-00597-6 |
Ejemplares similares
-
Kinase Signaling in Apoptosis Induced by Saturated Fatty Acids in Pancreatic β-Cells
por: Šrámek, Jan, et al.
Publicado: (2016) -
Effect of Saturated Stearic Acid on MAP Kinase and ER Stress Signaling Pathways during Apoptosis Induction in Human Pancreatic β-Cells Is Inhibited by Unsaturated Oleic Acid
por: Šrámek, Jan, et al.
Publicado: (2017) -
Molecular Mechanisms of Apoptosis Induction and Its Regulation by Fatty Acids in Pancreatic β-Cells
por: Šrámek, Jan, et al.
Publicado: (2021) -
p38 MAPK Is Activated but Does Not Play a Key Role during Apoptosis Induction by Saturated Fatty Acid in Human Pancreatic β-Cells
por: Šrámek, Jan, et al.
Publicado: (2016) -
Hypoxia Modulates Effects of Fatty Acids on NES2Y Human Pancreatic β-cells
por: Šrámek, Jan, et al.
Publicado: (2019)