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Thyroid Profile and Factors Associated with Hypothyroidism Among Multidrug-Resistant Tuberculosis Patients Attending Saint Peter’s Specialized Hospital Addis Ababa, Ethiopia

BACKGROUND: The emergence of MDR-TB is a global public health problem. Hypothyroidism is one of the severe adverse drug reactions (ADRs) in MDR-TB patients on treatment. Representative data on hypothyroidism and its associated factors among MDR-TB patients are lacking. OBJECTIVE: To determine thyroi...

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Autores principales: Biranu, Endalkchew, Wolde, Mistire, Edao Negesso, Abebe, Hailu Tola, Habteyes, Molla Sisay, Million
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285920/
https://www.ncbi.nlm.nih.gov/pubmed/34285520
http://dx.doi.org/10.2147/IDR.S310404
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author Biranu, Endalkchew
Wolde, Mistire
Edao Negesso, Abebe
Hailu Tola, Habteyes
Molla Sisay, Million
author_facet Biranu, Endalkchew
Wolde, Mistire
Edao Negesso, Abebe
Hailu Tola, Habteyes
Molla Sisay, Million
author_sort Biranu, Endalkchew
collection PubMed
description BACKGROUND: The emergence of MDR-TB is a global public health problem. Hypothyroidism is one of the severe adverse drug reactions (ADRs) in MDR-TB patients on treatment. Representative data on hypothyroidism and its associated factors among MDR-TB patients are lacking. OBJECTIVE: To determine thyroid profiles and associated risk factors among multidrug-resistant TB patients during therapy with anti-MDR-TB regimen in Saint Peter Specialized Hospital Addis Ababa, Ethiopia from January to November 2020. METHODS: A cross-sectional study was conducted in MDR-TB patients in Addis Ababa, Ethiopia. A total of 162 patients, who were older than 18 years, had bacteriologically confirmed MDR-TB and on treatment for more than one month were enrolled consecutively from the TB registration book. However, critically sick patients and those who were receiving additional drugs known to cause severe ADRs were excluded. Simple descriptive statistics were used to present the socio-demographic and clinical characteristics of the patients. A logistic regression model was used to assess the association between independent and dependent variables. A p-value <0.05 was considered as statistically significant in all analyses. RESULTS: Mean age of the study participant was 35.9 ± 13.6 years. The prevalence of hypothyroidism was 32 (19.8%). The presence of co-morbidity, being underweight, and prothionamide use were significantly associated with hypothyroidism in MDR-TB patients on treatment. CONCLUSION: Hypothyroidism occurs commonly among MDR-TB patients. Presence of co-morbidity, being underweight, and prothionamide drug use are the factors associated with hypothyroidism. Monitoring of thyroid function test during MDR-TB treatment and factors associated with hypothyroidism require attention to prevent complication.
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spelling pubmed-82859202021-07-19 Thyroid Profile and Factors Associated with Hypothyroidism Among Multidrug-Resistant Tuberculosis Patients Attending Saint Peter’s Specialized Hospital Addis Ababa, Ethiopia Biranu, Endalkchew Wolde, Mistire Edao Negesso, Abebe Hailu Tola, Habteyes Molla Sisay, Million Infect Drug Resist Original Research BACKGROUND: The emergence of MDR-TB is a global public health problem. Hypothyroidism is one of the severe adverse drug reactions (ADRs) in MDR-TB patients on treatment. Representative data on hypothyroidism and its associated factors among MDR-TB patients are lacking. OBJECTIVE: To determine thyroid profiles and associated risk factors among multidrug-resistant TB patients during therapy with anti-MDR-TB regimen in Saint Peter Specialized Hospital Addis Ababa, Ethiopia from January to November 2020. METHODS: A cross-sectional study was conducted in MDR-TB patients in Addis Ababa, Ethiopia. A total of 162 patients, who were older than 18 years, had bacteriologically confirmed MDR-TB and on treatment for more than one month were enrolled consecutively from the TB registration book. However, critically sick patients and those who were receiving additional drugs known to cause severe ADRs were excluded. Simple descriptive statistics were used to present the socio-demographic and clinical characteristics of the patients. A logistic regression model was used to assess the association between independent and dependent variables. A p-value <0.05 was considered as statistically significant in all analyses. RESULTS: Mean age of the study participant was 35.9 ± 13.6 years. The prevalence of hypothyroidism was 32 (19.8%). The presence of co-morbidity, being underweight, and prothionamide use were significantly associated with hypothyroidism in MDR-TB patients on treatment. CONCLUSION: Hypothyroidism occurs commonly among MDR-TB patients. Presence of co-morbidity, being underweight, and prothionamide drug use are the factors associated with hypothyroidism. Monitoring of thyroid function test during MDR-TB treatment and factors associated with hypothyroidism require attention to prevent complication. Dove 2021-07-12 /pmc/articles/PMC8285920/ /pubmed/34285520 http://dx.doi.org/10.2147/IDR.S310404 Text en © 2021 Biranu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Biranu, Endalkchew
Wolde, Mistire
Edao Negesso, Abebe
Hailu Tola, Habteyes
Molla Sisay, Million
Thyroid Profile and Factors Associated with Hypothyroidism Among Multidrug-Resistant Tuberculosis Patients Attending Saint Peter’s Specialized Hospital Addis Ababa, Ethiopia
title Thyroid Profile and Factors Associated with Hypothyroidism Among Multidrug-Resistant Tuberculosis Patients Attending Saint Peter’s Specialized Hospital Addis Ababa, Ethiopia
title_full Thyroid Profile and Factors Associated with Hypothyroidism Among Multidrug-Resistant Tuberculosis Patients Attending Saint Peter’s Specialized Hospital Addis Ababa, Ethiopia
title_fullStr Thyroid Profile and Factors Associated with Hypothyroidism Among Multidrug-Resistant Tuberculosis Patients Attending Saint Peter’s Specialized Hospital Addis Ababa, Ethiopia
title_full_unstemmed Thyroid Profile and Factors Associated with Hypothyroidism Among Multidrug-Resistant Tuberculosis Patients Attending Saint Peter’s Specialized Hospital Addis Ababa, Ethiopia
title_short Thyroid Profile and Factors Associated with Hypothyroidism Among Multidrug-Resistant Tuberculosis Patients Attending Saint Peter’s Specialized Hospital Addis Ababa, Ethiopia
title_sort thyroid profile and factors associated with hypothyroidism among multidrug-resistant tuberculosis patients attending saint peter’s specialized hospital addis ababa, ethiopia
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285920/
https://www.ncbi.nlm.nih.gov/pubmed/34285520
http://dx.doi.org/10.2147/IDR.S310404
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