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Biotransformation modulates the penetration of metallic nanomaterials across an artificial blood–brain barrier model

Understanding the potential of nanomaterials (NMs) to cross the blood–brain barrier (BBB), as a function of their physicochemical properties and subsequent behavior, fate, and adverse effect beyond that point, is vital for evaluating the neurological effects arising from their unintentional entry in...

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Autores principales: Guo, Zhiling, Zhang, Peng, Chakraborty, Swaroop, Chetwynd, Andrew J, Abdolahpur Monikh, Fazel, Stark, Christopher, Ali-Boucetta, Hanene, Wilson, Sandra, Lynch, Iseult, Valsami-Jones, Eugenia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285959/
https://www.ncbi.nlm.nih.gov/pubmed/34260400
http://dx.doi.org/10.1073/pnas.2105245118
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author Guo, Zhiling
Zhang, Peng
Chakraborty, Swaroop
Chetwynd, Andrew J
Abdolahpur Monikh, Fazel
Stark, Christopher
Ali-Boucetta, Hanene
Wilson, Sandra
Lynch, Iseult
Valsami-Jones, Eugenia
author_facet Guo, Zhiling
Zhang, Peng
Chakraborty, Swaroop
Chetwynd, Andrew J
Abdolahpur Monikh, Fazel
Stark, Christopher
Ali-Boucetta, Hanene
Wilson, Sandra
Lynch, Iseult
Valsami-Jones, Eugenia
author_sort Guo, Zhiling
collection PubMed
description Understanding the potential of nanomaterials (NMs) to cross the blood–brain barrier (BBB), as a function of their physicochemical properties and subsequent behavior, fate, and adverse effect beyond that point, is vital for evaluating the neurological effects arising from their unintentional entry into the brain, which is yet to be fully explored. This is not only due to the complex nature of the brain but also the existing analytical limitations for characterization and quantification of NMs in the complex brain environment. By using a fit-for-purpose analytical workflow and an in vitro BBB model, we show that the physiochemical properties of metallic NMs influence their biotransformation in biological matrices, which in turn modulates the transport form, efficiency, amounts, and pathways of NMs through the BBB and, consequently, their neurotoxicity. The data presented here will support in silico modeling and prediction of the neurotoxicity of NMs and facilitate the tailored design of safe NMs.
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spelling pubmed-82859592021-07-26 Biotransformation modulates the penetration of metallic nanomaterials across an artificial blood–brain barrier model Guo, Zhiling Zhang, Peng Chakraborty, Swaroop Chetwynd, Andrew J Abdolahpur Monikh, Fazel Stark, Christopher Ali-Boucetta, Hanene Wilson, Sandra Lynch, Iseult Valsami-Jones, Eugenia Proc Natl Acad Sci U S A Physical Sciences Understanding the potential of nanomaterials (NMs) to cross the blood–brain barrier (BBB), as a function of their physicochemical properties and subsequent behavior, fate, and adverse effect beyond that point, is vital for evaluating the neurological effects arising from their unintentional entry into the brain, which is yet to be fully explored. This is not only due to the complex nature of the brain but also the existing analytical limitations for characterization and quantification of NMs in the complex brain environment. By using a fit-for-purpose analytical workflow and an in vitro BBB model, we show that the physiochemical properties of metallic NMs influence their biotransformation in biological matrices, which in turn modulates the transport form, efficiency, amounts, and pathways of NMs through the BBB and, consequently, their neurotoxicity. The data presented here will support in silico modeling and prediction of the neurotoxicity of NMs and facilitate the tailored design of safe NMs. National Academy of Sciences 2021-07-13 2021-07-06 /pmc/articles/PMC8285959/ /pubmed/34260400 http://dx.doi.org/10.1073/pnas.2105245118 Text en Copyright © 2021 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Physical Sciences
Guo, Zhiling
Zhang, Peng
Chakraborty, Swaroop
Chetwynd, Andrew J
Abdolahpur Monikh, Fazel
Stark, Christopher
Ali-Boucetta, Hanene
Wilson, Sandra
Lynch, Iseult
Valsami-Jones, Eugenia
Biotransformation modulates the penetration of metallic nanomaterials across an artificial blood–brain barrier model
title Biotransformation modulates the penetration of metallic nanomaterials across an artificial blood–brain barrier model
title_full Biotransformation modulates the penetration of metallic nanomaterials across an artificial blood–brain barrier model
title_fullStr Biotransformation modulates the penetration of metallic nanomaterials across an artificial blood–brain barrier model
title_full_unstemmed Biotransformation modulates the penetration of metallic nanomaterials across an artificial blood–brain barrier model
title_short Biotransformation modulates the penetration of metallic nanomaterials across an artificial blood–brain barrier model
title_sort biotransformation modulates the penetration of metallic nanomaterials across an artificial blood–brain barrier model
topic Physical Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285959/
https://www.ncbi.nlm.nih.gov/pubmed/34260400
http://dx.doi.org/10.1073/pnas.2105245118
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