Ambulacrarian insulin-related peptides and their putative receptors suggest how insulin and similar peptides may have evolved from insulin-like growth factor

BACKGROUND: Some insulin/IGF-related peptides (irps) stimulate a receptor tyrosine kinase (RTK) that transfers the extracellular hormonal signal into an intracellular response. Other irps, such as relaxin, do not use an RTK, but a G-protein coupled receptor (GPCR). This is unusual since evolutionari...

Descripción completa

Detalles Bibliográficos
Autor principal: Veenstra, Jan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2021
Materias:
Bioinformatics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286064/
https://www.ncbi.nlm.nih.gov/pubmed/34316411
http://dx.doi.org/10.7717/peerj.11799

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286064/
https://www.ncbi.nlm.nih.gov/pubmed/34316411
http://dx.doi.org/10.7717/peerj.11799

Ejemplares similares