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Ambulacrarian insulin-related peptides and their putative receptors suggest how insulin and similar peptides may have evolved from insulin-like growth factor
BACKGROUND: Some insulin/IGF-related peptides (irps) stimulate a receptor tyrosine kinase (RTK) that transfers the extracellular hormonal signal into an intracellular response. Other irps, such as relaxin, do not use an RTK, but a G-protein coupled receptor (GPCR). This is unusual since evolutionari...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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PeerJ Inc.
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286064/ https://www.ncbi.nlm.nih.gov/pubmed/34316411 http://dx.doi.org/10.7717/peerj.11799 |