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Predictive Value of C-Reactive Protein-to-Albumin Ratio for Neonatal Sepsis

PURPOSE: Previous studies have reported that C-reactive protein-to-albumin ratio (CAR) was a risk factor for sepsis in adults. However, little is known regarding the role of CAR in neonates with sepsis. The aim of this study was to explore the relationship between CAR and neonatal sepsis. PATIENTS A...

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Autores principales: Li, Tiewei, Li, Xiaojuan, Wei, Yulei, Dong, Geng, Yang, Jianwei, Yang, Junmei, Fang, Panpan, Qi, Minglu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286121/
https://www.ncbi.nlm.nih.gov/pubmed/34285544
http://dx.doi.org/10.2147/JIR.S321074
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author Li, Tiewei
Li, Xiaojuan
Wei, Yulei
Dong, Geng
Yang, Jianwei
Yang, Junmei
Fang, Panpan
Qi, Minglu
author_facet Li, Tiewei
Li, Xiaojuan
Wei, Yulei
Dong, Geng
Yang, Jianwei
Yang, Junmei
Fang, Panpan
Qi, Minglu
author_sort Li, Tiewei
collection PubMed
description PURPOSE: Previous studies have reported that C-reactive protein-to-albumin ratio (CAR) was a risk factor for sepsis in adults. However, little is known regarding the role of CAR in neonates with sepsis. The aim of this study was to explore the relationship between CAR and neonatal sepsis. PATIENTS AND METHODS: In this research, from January 2016 to February 2020, a total of 1076 neonates were enrolled at Henan Children’s Hospital in China. Complete clinical and laboratory data were collected. To identify the potential independent risk factor for neonatal sepsis, multivariate logistic regression analysis was performed. Receiver operating characteristic (ROC) curve analysis was used to evaluate the prediction accuracy of CAR in identifying neonatal sepsis. RESULTS: CAR levels were higher in neonates with sepsis and showed a gradual increase among the control group, mild sepsis group and severe sepsis group. The prevalence of neonates with overall sepsis, mild sepsis and severe sepsis increased significantly from CAR tertile 1 to tertile 3. Multiple logistic regression analysis showed that CAR was an independent risk factor for the presence of sepsis (OR = 10.144, 95% CI 4.151–24.790, P < 0.001) and severe sepsis (OR = 1.876, 95% CI 1.562–2.253, P < 0.001). ROC curve analysis showed that CAR had a well discriminatory power in predicting sepsis (area under curve (AUC) = 0.74, 95% CI, 0.71–0.77, P < 0.001) and severe sepsis (AUC = 0.70, 95% CI, 0.67–0.74, P < 0.001). CONCLUSION: CAR was an independent predictor for the presence and severity of neonatal sepsis.
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spelling pubmed-82861212021-07-19 Predictive Value of C-Reactive Protein-to-Albumin Ratio for Neonatal Sepsis Li, Tiewei Li, Xiaojuan Wei, Yulei Dong, Geng Yang, Jianwei Yang, Junmei Fang, Panpan Qi, Minglu J Inflamm Res Original Research PURPOSE: Previous studies have reported that C-reactive protein-to-albumin ratio (CAR) was a risk factor for sepsis in adults. However, little is known regarding the role of CAR in neonates with sepsis. The aim of this study was to explore the relationship between CAR and neonatal sepsis. PATIENTS AND METHODS: In this research, from January 2016 to February 2020, a total of 1076 neonates were enrolled at Henan Children’s Hospital in China. Complete clinical and laboratory data were collected. To identify the potential independent risk factor for neonatal sepsis, multivariate logistic regression analysis was performed. Receiver operating characteristic (ROC) curve analysis was used to evaluate the prediction accuracy of CAR in identifying neonatal sepsis. RESULTS: CAR levels were higher in neonates with sepsis and showed a gradual increase among the control group, mild sepsis group and severe sepsis group. The prevalence of neonates with overall sepsis, mild sepsis and severe sepsis increased significantly from CAR tertile 1 to tertile 3. Multiple logistic regression analysis showed that CAR was an independent risk factor for the presence of sepsis (OR = 10.144, 95% CI 4.151–24.790, P < 0.001) and severe sepsis (OR = 1.876, 95% CI 1.562–2.253, P < 0.001). ROC curve analysis showed that CAR had a well discriminatory power in predicting sepsis (area under curve (AUC) = 0.74, 95% CI, 0.71–0.77, P < 0.001) and severe sepsis (AUC = 0.70, 95% CI, 0.67–0.74, P < 0.001). CONCLUSION: CAR was an independent predictor for the presence and severity of neonatal sepsis. Dove 2021-07-13 /pmc/articles/PMC8286121/ /pubmed/34285544 http://dx.doi.org/10.2147/JIR.S321074 Text en © 2021 Li et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Li, Tiewei
Li, Xiaojuan
Wei, Yulei
Dong, Geng
Yang, Jianwei
Yang, Junmei
Fang, Panpan
Qi, Minglu
Predictive Value of C-Reactive Protein-to-Albumin Ratio for Neonatal Sepsis
title Predictive Value of C-Reactive Protein-to-Albumin Ratio for Neonatal Sepsis
title_full Predictive Value of C-Reactive Protein-to-Albumin Ratio for Neonatal Sepsis
title_fullStr Predictive Value of C-Reactive Protein-to-Albumin Ratio for Neonatal Sepsis
title_full_unstemmed Predictive Value of C-Reactive Protein-to-Albumin Ratio for Neonatal Sepsis
title_short Predictive Value of C-Reactive Protein-to-Albumin Ratio for Neonatal Sepsis
title_sort predictive value of c-reactive protein-to-albumin ratio for neonatal sepsis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286121/
https://www.ncbi.nlm.nih.gov/pubmed/34285544
http://dx.doi.org/10.2147/JIR.S321074
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