Dysregulation of lncRNA in Helicobacter pylori-Infected Gastric Cancer Cells

Helicobacter pylori (H. pylori) infection is the most common cause of gastric cancer (GC). This microorganism is genetically diverse; GC is caused by several genetic deregulations in addition to environmental factors and bacterial virulence factors. lncRNAs (long noncoding RNAs) are significant biol...

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Detalles Bibliográficos
Autores principales: Yousefi, Leila, Osquee, Hamid Owaysee, Ghotaslou, Reza, Rezaee, Mohammad Ahangarzadeh, Pirzadeh, Tahereh, Sadeghi, Javid, Hemmati, Fatemeh, Yousefi, Bahman, Moaddab, Seyyed Yaghoub, Yousefi, Mehdi, Shirmohammadi, Masoud, Somi, Mohammad Hossein, Ganbarov, Khudaverdi, Kafil, Hossein Samadi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286195/
https://www.ncbi.nlm.nih.gov/pubmed/34337048
http://dx.doi.org/10.1155/2021/6911734
Descripción
Sumario:Helicobacter pylori (H. pylori) infection is the most common cause of gastric cancer (GC). This microorganism is genetically diverse; GC is caused by several genetic deregulations in addition to environmental factors and bacterial virulence factors. lncRNAs (long noncoding RNAs) are significant biological macromolecules in GC, have specific functions in diseases, and could be therapeutic targets. Altered lncRNAs can lead to the abnormal expression of adjacent protein-coding genes, which may be important in cancer development. Their mechanisms have not been well understood, so we are going to investigate the risk of GC in a population with both high lncRNA and H. pylori infection.

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