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Differences in topological properties of functional brain networks between menstrually-related and non-menstrual migraine without aura
Menstrually-related migraine without aura refers to a specific type of migraine that is associated with the female ovarian cycle. Compared with non-menstrual migraine without aura, in menstrually-related migraine without aura, there are additional attacks of migraine outside of the menstrual period....
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286221/ https://www.ncbi.nlm.nih.gov/pubmed/32705466 http://dx.doi.org/10.1007/s11682-020-00344-0 |
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author | Zhang, Yutong Xu, Tao Wang, Ziwen Li, Dehua Du, Jiarong Wen, Yi Zhao, Yu Liao, Huaqiang Liang, Fanrong Zhao, Ling |
author_facet | Zhang, Yutong Xu, Tao Wang, Ziwen Li, Dehua Du, Jiarong Wen, Yi Zhao, Yu Liao, Huaqiang Liang, Fanrong Zhao, Ling |
author_sort | Zhang, Yutong |
collection | PubMed |
description | Menstrually-related migraine without aura refers to a specific type of migraine that is associated with the female ovarian cycle. Compared with non-menstrual migraine without aura, in menstrually-related migraine without aura, there are additional attacks of migraine outside of the menstrual period. Menstrually-related migraine without aura tends to be less responsive to acute treatment and more prone to relapse than non-menstrual migraine without aura. Currently menstrually-related migraine without aura is treated no differently from any other migraine but, the differences in the central mechanisms underlying menstrually-related migraine without aura and non-menstrual migraine without aura remain poorly understood. Here, using resting-state functional magnetic resonance imaging and graph theory approaches, we aimed to explore the differences in topological properties of functional networks in 51 menstrually-related migraine without aura patients and 47 non-menstrual migraine without aura patients. The major finding of our study was that significant differences in topological properties between the two groups were mainly evident in the nodal centrality of the inferior frontal gyrus and the thalamus. Nodal centrality in inferior frontal gyrus was negatively correlated with Headache Impact Test questionnaire scores in the menstrually-related migraine without aura patients. Partial least squares correlation analysis revealed enhanced correlations of inferior frontal gyrus to pain-related behavior in the non-menstrual migraine without aura group, while within the menstrually-related migraine without aura group these effects were non-significant. These results indicate that the regulatory mechanisms in the central nervous system may differ between the two subtypes of migraine. The results provide novel insights into the pathophysiology of different subtypes of migraine, and could help us to enhance their clinical diagnosis and treatment. |
format | Online Article Text |
id | pubmed-8286221 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-82862212021-07-20 Differences in topological properties of functional brain networks between menstrually-related and non-menstrual migraine without aura Zhang, Yutong Xu, Tao Wang, Ziwen Li, Dehua Du, Jiarong Wen, Yi Zhao, Yu Liao, Huaqiang Liang, Fanrong Zhao, Ling Brain Imaging Behav Original Research Menstrually-related migraine without aura refers to a specific type of migraine that is associated with the female ovarian cycle. Compared with non-menstrual migraine without aura, in menstrually-related migraine without aura, there are additional attacks of migraine outside of the menstrual period. Menstrually-related migraine without aura tends to be less responsive to acute treatment and more prone to relapse than non-menstrual migraine without aura. Currently menstrually-related migraine without aura is treated no differently from any other migraine but, the differences in the central mechanisms underlying menstrually-related migraine without aura and non-menstrual migraine without aura remain poorly understood. Here, using resting-state functional magnetic resonance imaging and graph theory approaches, we aimed to explore the differences in topological properties of functional networks in 51 menstrually-related migraine without aura patients and 47 non-menstrual migraine without aura patients. The major finding of our study was that significant differences in topological properties between the two groups were mainly evident in the nodal centrality of the inferior frontal gyrus and the thalamus. Nodal centrality in inferior frontal gyrus was negatively correlated with Headache Impact Test questionnaire scores in the menstrually-related migraine without aura patients. Partial least squares correlation analysis revealed enhanced correlations of inferior frontal gyrus to pain-related behavior in the non-menstrual migraine without aura group, while within the menstrually-related migraine without aura group these effects were non-significant. These results indicate that the regulatory mechanisms in the central nervous system may differ between the two subtypes of migraine. The results provide novel insights into the pathophysiology of different subtypes of migraine, and could help us to enhance their clinical diagnosis and treatment. Springer US 2020-07-23 2021 /pmc/articles/PMC8286221/ /pubmed/32705466 http://dx.doi.org/10.1007/s11682-020-00344-0 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Research Zhang, Yutong Xu, Tao Wang, Ziwen Li, Dehua Du, Jiarong Wen, Yi Zhao, Yu Liao, Huaqiang Liang, Fanrong Zhao, Ling Differences in topological properties of functional brain networks between menstrually-related and non-menstrual migraine without aura |
title | Differences in topological properties of functional brain networks between menstrually-related and non-menstrual migraine without aura |
title_full | Differences in topological properties of functional brain networks between menstrually-related and non-menstrual migraine without aura |
title_fullStr | Differences in topological properties of functional brain networks between menstrually-related and non-menstrual migraine without aura |
title_full_unstemmed | Differences in topological properties of functional brain networks between menstrually-related and non-menstrual migraine without aura |
title_short | Differences in topological properties of functional brain networks between menstrually-related and non-menstrual migraine without aura |
title_sort | differences in topological properties of functional brain networks between menstrually-related and non-menstrual migraine without aura |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286221/ https://www.ncbi.nlm.nih.gov/pubmed/32705466 http://dx.doi.org/10.1007/s11682-020-00344-0 |
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