Cargando…
Degradation from the outside-in: targeting extracellular and membrane proteins for degradation through the endo-lysosomal pathway
Targeted protein degradation (TPD) is a promising strategy to remove deleterious proteins for therapeutic benefit and to probe biological pathways. The past two decades have witnessed a surge in the development of technologies that rely on intracellular machinery to degrade challenging cytosolic tar...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286304/ https://www.ncbi.nlm.nih.gov/pubmed/33770486 http://dx.doi.org/10.1016/j.chembiol.2021.02.024 |