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Is Neutrophil–Lymphocyte Count Ratio a Better Indicator of Sepsis with Gram-positive Bacterial Infection?

BACKGROUND: Sepsis is the main cause of death in infectious diseases that can be caused by gram-negative or gram-positive bacteria. Definitive therapy for sepsis is antibiotics, depending on blood culture results even though it takes time for bacterial growth. Neutrophil–lymphocyte count ratio (NLCR...

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Autores principales: Sumardi, Uun, Prihardianti, Diah R, Sudjana, Primal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Jaypee Brothers Medical Publishers 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286383/
https://www.ncbi.nlm.nih.gov/pubmed/34316175
http://dx.doi.org/10.5005/jp-journals-10071-23892
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author Sumardi, Uun
Prihardianti, Diah R
Sudjana, Primal
author_facet Sumardi, Uun
Prihardianti, Diah R
Sudjana, Primal
author_sort Sumardi, Uun
collection PubMed
description BACKGROUND: Sepsis is the main cause of death in infectious diseases that can be caused by gram-negative or gram-positive bacteria. Definitive therapy for sepsis is antibiotics, depending on blood culture results even though it takes time for bacterial growth. Neutrophil–lymphocyte count ratio (NLCR) is a laboratory parameter that can predict bacterial infection in sepsis patients. NLCR is time-and-cost-effective and easy-to-use in daily practice, in sepsis patients infected with gram-negative, gram-positive, and no bacterial growth based on blood culture results. MATERIALS AND METHODS: This was a comparative study of NLCR and the result of blood culture from sepsis patients. Subjects were obtained from the medical records of patients admitted to our hospital from January 2019 to May 2019. Patients aged over 18 years who were diagnosed with sepsis and had blood culture information were included. Patients with hematological disorder and malignancy were excluded. Sepsis data consisted of gender, age, source of infection, comorbidity, NLCR, and blood culture results. RESULTS: Ninety-four sepsis subjects met the inclusion criteria, and fifty-one subjects (54.25%)—33 subjects (35.10%) with gram-negative bacterial infection and 18 subjects (19.15%) with gram-positive bacterial infection—were included in the analysis due to the completeness of the data. The median NLCR (IQR) was 17.8 (14.3–30.7) in gram-negative, 31.5 (26.3–95.0) in gram-positive, and 22.8 (15.67–22.75) in no bacterial growth (p = 0.001). CONCLUSION: NLCR can distinguish gram-negative and gram-positive bacterial infections. It also can predict the possibility of pathogenic bacteria that cause sepsis. HOW TO CITE THIS ARTICLE: Sumardi U, Prihardianti DR, Sudjana P. Is Neutrophil–Lymphocyte Count Ratio a Better Indicator of Sepsis with Gram-positive Bacterial Infection? Indian J Crit Care Med 2021;25(7):795–799.
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spelling pubmed-82863832021-07-26 Is Neutrophil–Lymphocyte Count Ratio a Better Indicator of Sepsis with Gram-positive Bacterial Infection? Sumardi, Uun Prihardianti, Diah R Sudjana, Primal Indian J Crit Care Med Original Article BACKGROUND: Sepsis is the main cause of death in infectious diseases that can be caused by gram-negative or gram-positive bacteria. Definitive therapy for sepsis is antibiotics, depending on blood culture results even though it takes time for bacterial growth. Neutrophil–lymphocyte count ratio (NLCR) is a laboratory parameter that can predict bacterial infection in sepsis patients. NLCR is time-and-cost-effective and easy-to-use in daily practice, in sepsis patients infected with gram-negative, gram-positive, and no bacterial growth based on blood culture results. MATERIALS AND METHODS: This was a comparative study of NLCR and the result of blood culture from sepsis patients. Subjects were obtained from the medical records of patients admitted to our hospital from January 2019 to May 2019. Patients aged over 18 years who were diagnosed with sepsis and had blood culture information were included. Patients with hematological disorder and malignancy were excluded. Sepsis data consisted of gender, age, source of infection, comorbidity, NLCR, and blood culture results. RESULTS: Ninety-four sepsis subjects met the inclusion criteria, and fifty-one subjects (54.25%)—33 subjects (35.10%) with gram-negative bacterial infection and 18 subjects (19.15%) with gram-positive bacterial infection—were included in the analysis due to the completeness of the data. The median NLCR (IQR) was 17.8 (14.3–30.7) in gram-negative, 31.5 (26.3–95.0) in gram-positive, and 22.8 (15.67–22.75) in no bacterial growth (p = 0.001). CONCLUSION: NLCR can distinguish gram-negative and gram-positive bacterial infections. It also can predict the possibility of pathogenic bacteria that cause sepsis. HOW TO CITE THIS ARTICLE: Sumardi U, Prihardianti DR, Sudjana P. Is Neutrophil–Lymphocyte Count Ratio a Better Indicator of Sepsis with Gram-positive Bacterial Infection? Indian J Crit Care Med 2021;25(7):795–799. Jaypee Brothers Medical Publishers 2021-07 /pmc/articles/PMC8286383/ /pubmed/34316175 http://dx.doi.org/10.5005/jp-journals-10071-23892 Text en Copyright © 2021; Jaypee Brothers Medical Publishers (P) Ltd. https://creativecommons.org/licenses/by-nc/4.0/© Jaypee Brothers Medical Publishers. 2021 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and non-commercial reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated.
spellingShingle Original Article
Sumardi, Uun
Prihardianti, Diah R
Sudjana, Primal
Is Neutrophil–Lymphocyte Count Ratio a Better Indicator of Sepsis with Gram-positive Bacterial Infection?
title Is Neutrophil–Lymphocyte Count Ratio a Better Indicator of Sepsis with Gram-positive Bacterial Infection?
title_full Is Neutrophil–Lymphocyte Count Ratio a Better Indicator of Sepsis with Gram-positive Bacterial Infection?
title_fullStr Is Neutrophil–Lymphocyte Count Ratio a Better Indicator of Sepsis with Gram-positive Bacterial Infection?
title_full_unstemmed Is Neutrophil–Lymphocyte Count Ratio a Better Indicator of Sepsis with Gram-positive Bacterial Infection?
title_short Is Neutrophil–Lymphocyte Count Ratio a Better Indicator of Sepsis with Gram-positive Bacterial Infection?
title_sort is neutrophil–lymphocyte count ratio a better indicator of sepsis with gram-positive bacterial infection?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286383/
https://www.ncbi.nlm.nih.gov/pubmed/34316175
http://dx.doi.org/10.5005/jp-journals-10071-23892
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