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Association between rs11614913 Polymorphism of The MiR-196-a2 Gene and Colorectal Cancer in The Presence of Departure from Hardy-Weinberg Equilibrium
OBJECTIVE: Colorectal cancer (CRC) is the fourth most common and the second most lethal cancer worldwide. CRC mortality is increasing in Iran. In the current study, we aimed to investigate association between rs11614913 polymorphism of the miR-196-a2 gene and CRC. MATERIALS AND METHODS: In this case...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royan Institute
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286463/ https://www.ncbi.nlm.nih.gov/pubmed/34308574 http://dx.doi.org/10.22074/cellj.2021.7295 |
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author | Soltanian, Ali Reza Hosseini, Bistoon Mahjub, Hossein Bahreini, Fatemeh Ehsan, Nazemalhosseini Mojarad Ghaffari, Mohammad Ebrahim |
author_facet | Soltanian, Ali Reza Hosseini, Bistoon Mahjub, Hossein Bahreini, Fatemeh Ehsan, Nazemalhosseini Mojarad Ghaffari, Mohammad Ebrahim |
author_sort | Soltanian, Ali Reza |
collection | PubMed |
description | OBJECTIVE: Colorectal cancer (CRC) is the fourth most common and the second most lethal cancer worldwide. CRC mortality is increasing in Iran. In the current study, we aimed to investigate association between rs11614913 polymorphism of the miR-196-a2 gene and CRC. MATERIALS AND METHODS: In this case-control study, we assessed association of the rs11614913 polymorphism in 194 patients with CRC (case) and 286 healthy individuals (control). The expectation-maximization (EM) algorithm method was used to adjust deviation from Hardy-Weinberg equilibrium (HWE). RESULTS: There was no significant difference between genotypic frequencies of rs11614913 polymorphism in the control and case groups. Genotypic frequencies differed in the adjusted and unadjusted deviations from the HWE. Analysis of unadjusted and adjusted independent variables showed that age, sex, alcohol consumption, and drug use were statistically significant. CONCLUSION: Our findings showed that rs11614913 polymorphism was not associated with CRC risk. Deviation from HWE affected the results. It is recommended to perform further studies to establish HWE. Ignoring the equilibrium can cause in consistencies in the results of studies. |
format | Online Article Text |
id | pubmed-8286463 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Royan Institute |
record_format | MEDLINE/PubMed |
spelling | pubmed-82864632021-08-01 Association between rs11614913 Polymorphism of The MiR-196-a2 Gene and Colorectal Cancer in The Presence of Departure from Hardy-Weinberg Equilibrium Soltanian, Ali Reza Hosseini, Bistoon Mahjub, Hossein Bahreini, Fatemeh Ehsan, Nazemalhosseini Mojarad Ghaffari, Mohammad Ebrahim Cell J Original Article OBJECTIVE: Colorectal cancer (CRC) is the fourth most common and the second most lethal cancer worldwide. CRC mortality is increasing in Iran. In the current study, we aimed to investigate association between rs11614913 polymorphism of the miR-196-a2 gene and CRC. MATERIALS AND METHODS: In this case-control study, we assessed association of the rs11614913 polymorphism in 194 patients with CRC (case) and 286 healthy individuals (control). The expectation-maximization (EM) algorithm method was used to adjust deviation from Hardy-Weinberg equilibrium (HWE). RESULTS: There was no significant difference between genotypic frequencies of rs11614913 polymorphism in the control and case groups. Genotypic frequencies differed in the adjusted and unadjusted deviations from the HWE. Analysis of unadjusted and adjusted independent variables showed that age, sex, alcohol consumption, and drug use were statistically significant. CONCLUSION: Our findings showed that rs11614913 polymorphism was not associated with CRC risk. Deviation from HWE affected the results. It is recommended to perform further studies to establish HWE. Ignoring the equilibrium can cause in consistencies in the results of studies. Royan Institute 2021-08 2021-07-17 /pmc/articles/PMC8286463/ /pubmed/34308574 http://dx.doi.org/10.22074/cellj.2021.7295 Text en The Cell Journal (Yakhteh) is an open access journal which means the articles are freely available online for any individual author to download and use the providing address. The journal is licensed under a Creative Commons Attribution-Non Commercial 3.0 Unported License which allows the author(s) to hold the copyright without restrictions that is permitting unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited. https://creativecommons.org/licenses/by/3.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Soltanian, Ali Reza Hosseini, Bistoon Mahjub, Hossein Bahreini, Fatemeh Ehsan, Nazemalhosseini Mojarad Ghaffari, Mohammad Ebrahim Association between rs11614913 Polymorphism of The MiR-196-a2 Gene and Colorectal Cancer in The Presence of Departure from Hardy-Weinberg Equilibrium |
title | Association between rs11614913 Polymorphism of The
MiR-196-a2 Gene and Colorectal Cancer in The Presence
of Departure from Hardy-Weinberg Equilibrium |
title_full | Association between rs11614913 Polymorphism of The
MiR-196-a2 Gene and Colorectal Cancer in The Presence
of Departure from Hardy-Weinberg Equilibrium |
title_fullStr | Association between rs11614913 Polymorphism of The
MiR-196-a2 Gene and Colorectal Cancer in The Presence
of Departure from Hardy-Weinberg Equilibrium |
title_full_unstemmed | Association between rs11614913 Polymorphism of The
MiR-196-a2 Gene and Colorectal Cancer in The Presence
of Departure from Hardy-Weinberg Equilibrium |
title_short | Association between rs11614913 Polymorphism of The
MiR-196-a2 Gene and Colorectal Cancer in The Presence
of Departure from Hardy-Weinberg Equilibrium |
title_sort | association between rs11614913 polymorphism of the
mir-196-a2 gene and colorectal cancer in the presence
of departure from hardy-weinberg equilibrium |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286463/ https://www.ncbi.nlm.nih.gov/pubmed/34308574 http://dx.doi.org/10.22074/cellj.2021.7295 |
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