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Re-infection with a different SARS-CoV-2 clade and prolonged viral shedding in a hematopoietic stem cell transplantation patient

Immunocompromised patients who have a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection pose many clinical and public health challenges. We describe the case of a hematopoietic stem cell transplantation patient with lymphoma who had a protracted illness requiring three consecuti...

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Autores principales: Alshukairi, Abeer N., El-Kafrawy, Sherif A., Dada, Ashraf, Yasir, Muhammad, Yamani, Amani H., Saeedi, Mohammed F., Aljohaney, Ahmed, AlJohani, Naif I., Bahaudden, Husam A., Alam, Intikhab, Gojobori, Takashi, Radovanovic, Aleksandar, Alandijany, Thamir A., Othman, Norah A., Alsubhi, Tagreed L., Hassan, Ahmed M., Tolah, Ahmed M., Al-Tawfiq, Jaffar A., Zumla, Alimuddin, Azhar, Esam I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286546/
https://www.ncbi.nlm.nih.gov/pubmed/34289407
http://dx.doi.org/10.1016/j.ijid.2021.07.036
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author Alshukairi, Abeer N.
El-Kafrawy, Sherif A.
Dada, Ashraf
Yasir, Muhammad
Yamani, Amani H.
Saeedi, Mohammed F.
Aljohaney, Ahmed
AlJohani, Naif I.
Bahaudden, Husam A.
Alam, Intikhab
Gojobori, Takashi
Radovanovic, Aleksandar
Alandijany, Thamir A.
Othman, Norah A.
Alsubhi, Tagreed L.
Hassan, Ahmed M.
Tolah, Ahmed M.
Al-Tawfiq, Jaffar A.
Zumla, Alimuddin
Azhar, Esam I
author_facet Alshukairi, Abeer N.
El-Kafrawy, Sherif A.
Dada, Ashraf
Yasir, Muhammad
Yamani, Amani H.
Saeedi, Mohammed F.
Aljohaney, Ahmed
AlJohani, Naif I.
Bahaudden, Husam A.
Alam, Intikhab
Gojobori, Takashi
Radovanovic, Aleksandar
Alandijany, Thamir A.
Othman, Norah A.
Alsubhi, Tagreed L.
Hassan, Ahmed M.
Tolah, Ahmed M.
Al-Tawfiq, Jaffar A.
Zumla, Alimuddin
Azhar, Esam I
author_sort Alshukairi, Abeer N.
collection PubMed
description Immunocompromised patients who have a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection pose many clinical and public health challenges. We describe the case of a hematopoietic stem cell transplantation patient with lymphoma who had a protracted illness requiring three consecutive hospital admissions. Whole genome sequencing confirmed two different SARS-CoV-2 clades. Clinical management issues and the unanswered questions arising from this case are discussed.
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spelling pubmed-82865462021-07-20 Re-infection with a different SARS-CoV-2 clade and prolonged viral shedding in a hematopoietic stem cell transplantation patient Alshukairi, Abeer N. El-Kafrawy, Sherif A. Dada, Ashraf Yasir, Muhammad Yamani, Amani H. Saeedi, Mohammed F. Aljohaney, Ahmed AlJohani, Naif I. Bahaudden, Husam A. Alam, Intikhab Gojobori, Takashi Radovanovic, Aleksandar Alandijany, Thamir A. Othman, Norah A. Alsubhi, Tagreed L. Hassan, Ahmed M. Tolah, Ahmed M. Al-Tawfiq, Jaffar A. Zumla, Alimuddin Azhar, Esam I Int J Infect Dis Case Report Immunocompromised patients who have a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection pose many clinical and public health challenges. We describe the case of a hematopoietic stem cell transplantation patient with lymphoma who had a protracted illness requiring three consecutive hospital admissions. Whole genome sequencing confirmed two different SARS-CoV-2 clades. Clinical management issues and the unanswered questions arising from this case are discussed. The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021-09 2021-07-18 /pmc/articles/PMC8286546/ /pubmed/34289407 http://dx.doi.org/10.1016/j.ijid.2021.07.036 Text en © 2021 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Case Report
Alshukairi, Abeer N.
El-Kafrawy, Sherif A.
Dada, Ashraf
Yasir, Muhammad
Yamani, Amani H.
Saeedi, Mohammed F.
Aljohaney, Ahmed
AlJohani, Naif I.
Bahaudden, Husam A.
Alam, Intikhab
Gojobori, Takashi
Radovanovic, Aleksandar
Alandijany, Thamir A.
Othman, Norah A.
Alsubhi, Tagreed L.
Hassan, Ahmed M.
Tolah, Ahmed M.
Al-Tawfiq, Jaffar A.
Zumla, Alimuddin
Azhar, Esam I
Re-infection with a different SARS-CoV-2 clade and prolonged viral shedding in a hematopoietic stem cell transplantation patient
title Re-infection with a different SARS-CoV-2 clade and prolonged viral shedding in a hematopoietic stem cell transplantation patient
title_full Re-infection with a different SARS-CoV-2 clade and prolonged viral shedding in a hematopoietic stem cell transplantation patient
title_fullStr Re-infection with a different SARS-CoV-2 clade and prolonged viral shedding in a hematopoietic stem cell transplantation patient
title_full_unstemmed Re-infection with a different SARS-CoV-2 clade and prolonged viral shedding in a hematopoietic stem cell transplantation patient
title_short Re-infection with a different SARS-CoV-2 clade and prolonged viral shedding in a hematopoietic stem cell transplantation patient
title_sort re-infection with a different sars-cov-2 clade and prolonged viral shedding in a hematopoietic stem cell transplantation patient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286546/
https://www.ncbi.nlm.nih.gov/pubmed/34289407
http://dx.doi.org/10.1016/j.ijid.2021.07.036
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