Cargando…

Intravenous administration of LPS activates the kynurenine pathway in healthy male human subjects: a prospective placebo-controlled cross-over trial

BACKGROUND: Administration of lipopolysaccharide (LPS) from Gram-negative bacteria, also known as the human endotoxemia model, is a standardized and safe model of human inflammation. Experimental studies have revealed that peripheral administration of LPS leads to induction of the kynurenine pathway...

Descripción completa

Detalles Bibliográficos
Autores principales:	Millischer, Vincent, Heinzl, Matthias, Faka, Anthi, Resl, Michael, Trepci, Ada, Klammer, Carmen, Egger, Margot, Dieplinger, Benjamin, Clodi, Martin, Schwieler, Lilly
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286561/ https://www.ncbi.nlm.nih.gov/pubmed/34273987 http://dx.doi.org/10.1186/s12974-021-02196-x

Ejemplares similares

Storm of Cardiovascular Markers After LPS Administration in Human Volunteers
por: Resl, Michael, et al.
Publicado: (2021)

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Is Not Induced in Artificial Human Inflammation and Is Not Correlated with Inflammatory Response
por: Heinzl, Matthias Wolfgang, et al.
Publicado: (2020)

Glucose and lipopolysaccharide differentially regulate fibroblast growth factor 21 in healthy male human volunteers – A prospective cross‐over trial
por: Pohlhammer, Johannes, et al.
Publicado: (2022)

SUBCLINICAL KIDNEY INJURY IS CAUSED BY A MODERATE SINGLE INFLAMMATORY EVENT
por: Heinzl, Matthias Wolfgang, et al.
Publicado: (2022)

Differential effects on blood and cerebrospinal fluid immune protein markers and kynurenine pathway metabolites from aerobic physical exercise in healthy subjects
por: Isung, Josef, et al.
Publicado: (2021)

Effect of repeated bolus and continuous glucose infusion on a panel of circulating biomarkers in healthy volunteers
por: Feldbauer, Roland, et al.
Publicado: (2022)

Quantification of Plasma Kynurenine Metabolites Following One Bout of Sprint Interval Exercise
por: Trepci, Ada, et al.
Publicado: (2020)

A novel, robust method for quantification of multiple kynurenine pathway metabolites in the cerebrospinal fluid
por: Schwieler, Lilly, et al.
Publicado: (2020)

The Kynurenine Pathway is Differentially Activated in Children with Lyme Disease and Tick-Borne Encephalitis
por: Wickström, Ronny, et al.
Publicado: (2021)

High Anti-CoV2S Antibody Levels at Hospitalization Are Associated with Improved Survival in Patients with COVID-19 Vaccine Breakthrough Infection
por: Heinzl, Matthias Wolfgang, et al.
Publicado: (2022)

Vitamin C and E Treatment Blocks Changes in Kynurenine Metabolism Triggered by Three Weeks of Sprint Interval Training in Recreationally Active Elderly Humans
por: Wyckelsma, Victoria L., et al.
Publicado: (2021)

Imbalanced Kynurenine Pathway in Schizophrenia
por: Kegel, Magdalena E, et al.
Publicado: (2014)

Evaluation of the EDI enzyme linked immunosorbent assays for the detection of SARS-CoV-2 IgM and IgG antibodies in human plasma
por: Bundschuh, Christian, et al.
Publicado: (2020)

Comparison of the Elecsys® Anti-SARS-CoV-2 immunoassay with the EDI™ enzyme linked immunosorbent assays for the detection of SARS-CoV-2 antibodies in human plasma
por: Egger, Margot, et al.
Publicado: (2020)

Electroconvulsive therapy suppresses the neurotoxic branch of the kynurenine pathway in treatment-resistant depressed patients
por: Schwieler, Lilly, et al.
Publicado: (2016)

B-Type Natriuretic Peptide Modulates Ghrelin, Hunger, and Satiety in Healthy Men
por: Vila, Greisa, et al.
Publicado: (2012)

Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria
por: Holmberg, Dag, et al.
Publicado: (2017)

Electroacupuncture attenuates LPS-induced depression-like behavior through kynurenine pathway
por: Wu, Xingying, et al.
Publicado: (2023)

Altered hippocampal plasticity by prenatal kynurenine administration, kynurenine-3-monoxygenase (KMO) deletion or galantamine
por: Forrest, C.M., et al.
Publicado: (2015)

The Effect of Systemic Nitroglycerin Administration on the Kynurenine Pathway in the Rat
por: Nagy-Grócz, Gábor, et al.
Publicado: (2017)

Therapie der Hyperglykämie bei erwachsenen, kritisch kranken PatientInnen (Update 2023)
por: Clodi, M., et al.
Publicado: (2023)

Commentary: The Effect of Systemic Nitroglycerin Administration on the Kynurenine Pathway in the Rat
por: Valença, Marcelo Moraes
Publicado: (2017)

Corrigendum: The Effect of Systemic Nitroglycerin Administration on the Kynurenine Pathway in the Rat
por: Nagy-Grócz, Gábor, et al.
Publicado: (2020)

The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors
por: Hughes, Tamera D., et al.
Publicado: (2022)

Analytical characterization and clinical evaluation of an enzyme-linked immunosorbent assay for measurement of afamin in human plasma()
por: Dieplinger, Benjamin, et al.
Publicado: (2013)

Homeostasis Imbalance of Microglia and Astrocytes Leads to Alteration in the Metabolites of the Kynurenine Pathway in LPS-Induced Depressive-Like Mice
por: Tao, Xue, et al.
Publicado: (2020)

Modulation of Enzyme Activity in the Kynurenine Pathway by Kynurenine Monooxygenase Inhibition
por: Phillips, Robert S., et al.
Publicado: (2019)

Are Kynurenines Accomplices or Principal Villains in Dementia? Maintenance of Kynurenine Metabolism
por: Tanaka, Masaru, et al.
Publicado: (2020)

Twelve-week physical exercise does not have a long-lasting effect on kynurenines in plasma of depressed patients
por: Millischer, Vincent, et al.
Publicado: (2017)

Tryptophan Metabolism in Rat Liver After Administration of Tryptophan, Kynurenine Metabolites, and Kynureninase Inhibitors
por: Badawy, Abdulla A.-B., et al.
Publicado: (2016)

Sodium Butyrate and Indole-3-propionic Acid Prevent the Increase of Cytokines and Kynurenine Levels in LPS-induced Human Primary Astrocytes
por: Garcez, Michelle L, et al.
Publicado: (2020)

Cluster headache and kynurenines
por: Tuka, Bernadett, et al.
Publicado: (2023)

Characteristic Features of Kynurenine Aminotransferase Allosterically Regulated by (Alpha)-Ketoglutarate in Cooperation with Kynurenine
por: Okada, Ken, et al.
Publicado: (2012)

The Intravenous Administration of Salvarsan
por: Gibson, H. R. B.
Publicado: (1911)

Peripheral and central levels of kynurenic acid in bipolar disorder subjects and healthy controls
por: Sellgren, Carl M., et al.
Publicado: (2019)

Rhodoquinone biosynthesis in C. elegans requires precursors generated by the kynurenine pathway
por: Del Borrello, Samantha, et al.
Publicado: (2019)

First trimester human umbilical cord perivascular cells (HUCPVC) modulate the kynurenine pathway and glutamate neurotransmission in an LPS-induced mouse model of neuroinflammation
por: Siddiqui, Fyyaz, et al.
Publicado: (2023)

Kynurenines, neurodegeneration and Alzheimer’s disease
por: Kincses, Zsigmond Tamas, et al.
Publicado: (2010)

Kynurenine pathway metabolites in migraine
por: Nicoletti, Ferdinando
Publicado: (2015)

Kynurenine: an oncometabolite in colon cancer
por: Venkateswaran, Niranjan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_st8027jsb55p2in7vidv7qrk0j