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C1q/TNF-related protein 4 restores leptin sensitivity by downregulating NF-κB signaling and microglial activation

OBJECTIVE: C1qTNF-related protein 4 (CTRP4) acts in the hypothalamus to modulate food intake in diet-induced obese mice and has been shown to exert an anti-inflammatory effect on macrophages. Since high-fat diet-induced microglial activation and hypothalamic inflammation impair leptin signaling and...

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Detalles Bibliográficos
Autores principales:	Ye, Liu, Jia, Gongwei, Li, Yuejie, Wang, Ying, Chen, Hong, Yu, Lehua, Wu, Dandong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286609/ https://www.ncbi.nlm.nih.gov/pubmed/34275474 http://dx.doi.org/10.1186/s12974-021-02167-2

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