Cargando…

C1q/TNF-related protein 4 restores leptin sensitivity by downregulating NF-κB signaling and microglial activation

OBJECTIVE: C1qTNF-related protein 4 (CTRP4) acts in the hypothalamus to modulate food intake in diet-induced obese mice and has been shown to exert an anti-inflammatory effect on macrophages. Since high-fat diet-induced microglial activation and hypothalamic inflammation impair leptin signaling and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ye, Liu, Jia, Gongwei, Li, Yuejie, Wang, Ying, Chen, Hong, Yu, Lehua, Wu, Dandong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286609/ https://www.ncbi.nlm.nih.gov/pubmed/34275474 http://dx.doi.org/10.1186/s12974-021-02167-2

Ejemplares similares

Downregulation of Macrophage-Specific Act-1 Intensifies Periodontitis and Alveolar Bone Loss Possibly via TNF/NF-κB Signaling
por: Pathak, Janak L., et al.
Publicado: (2021)

Anthocyanins Downregulate Lipopolysaccharide-Induced Inflammatory Responses in BV2 Microglial Cells by Suppressing the NF-κB and Akt/MAPKs Signaling Pathways
por: Jeong, Jin-Woo, et al.
Publicado: (2013)

TNFα-mediated activation of NF-κB downregulates sodium-iodide symporter expression in thyroid cells
por: Faria, Márcia, et al.
Publicado: (2020)

MiR-18a-downregulated RORA inhibits the proliferation and tumorigenesis of glioma using the TNF-α-mediated NF-κB signaling pathway
por: Jiang, Yang, et al.
Publicado: (2020)

Therapeutic effect of ulinastatin on pulmonary fibrosis via downregulation of TGF-β1, TNF-α and NF-κB
por: Li, Dejun, et al.
Publicado: (2018)

MCPIP1 Enhances TNF-α-Mediated Apoptosis through Downregulation of the NF-κB/cFLIP Axis
por: Suk, Fat-Moon, et al.
Publicado: (2021)

Single TNFα trimers mediating NF-κB activation: stochastic robustness of NF-κB signaling
por: Lipniacki, Tomasz, et al.
Publicado: (2007)

Papaverine inhibits lipopolysaccharide-induced microglial activation by suppressing NF-κB signaling pathway
por: Dang, Yalong, et al.
Publicado: (2016)

Xueliankoufuye Suppresses Microglial Activation with Inflammatory Pain by Blocking NF-κB Signaling Pathway
por: Shao, Shuai, et al.
Publicado: (2023)

Brain rhythms control microglial response and cytokine expression via NF-κB signaling
por: Prichard, Ashley, et al.
Publicado: (2023)

Divergent Neuroinflammatory Regulation of Microglial TREM Expression and Involvement of NF-κB
por: Owens, Rosie, et al.
Publicado: (2017)

LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways
por: Yang, Longyu, et al.
Publicado: (2016)

Betaine Mitigates Amyloid-β-Associated Neuroinflammation by Suppressing the NLRP3 and NF-κB Signaling Pathways in Microglial Cells
por: Zhang, Yue, et al.
Publicado: (2023)

Sensitizing leukemia stem cells to NF-κB inhibitor treatment in vivo by inactivation of both TNF and IL-1 signaling
por: Li, Jing, et al.
Publicado: (2016)

(+)-JQ1 attenuated LPS-induced microglial inflammation via MAPK/NFκB signaling
por: Wang, Huanhuan, et al.
Publicado: (2018)

Histone Deacetylase 6 Inhibition Restores Leptin Sensitivity and Reduces Obesity
por: Çakır, Işın, et al.
Publicado: (2022)

TNFα sensitizes hepatocytes to FasL-induced apoptosis by NFκB-mediated Fas upregulation
por: Faletti, Laura, et al.
Publicado: (2018)

Corrigendum: Divergent Neuroinflammatory Regulation of Microglial TREM Expression and Involvement of NF-κB
por: Owens, Rosie, et al.
Publicado: (2017)

JMJD8 is a positive regulator of TNF-induced NF-κB signaling
por: Yeo, Kok Siong, et al.
Publicado: (2016)

A network-centric approach to drugging TNF-induced NF-κB signaling
por: Pabon, Nicolas A., et al.
Publicado: (2019)

The Anti-neuroinflammatory Activity of Tectorigenin Pretreatment via Downregulated NF-κB and ERK/JNK Pathways in BV-2 Microglial and Microglia Inactivation in Mice With Lipopolysaccharide
por: Lim, Hye-Sun, et al.
Publicado: (2018)

Shuangtengbitong tincture treatment of collagen-induced arthritis via downregulation of the expression of IL-6, IL-8, TNF-α and NF-κB
por: CHU, KEDAN, et al.
Publicado: (2013)

Nicotinamide n-Oxide Attenuates HSV-1-Induced Microglial Inflammation through Sirtuin-1/NF-κB Signaling
por: Song, Xiaowei, et al.
Publicado: (2022)

PMS1077 Sensitizes TNF-α Induced Apoptosis in Human Prostate Cancer Cells by Blocking NF-κB Signaling Pathway
por: Shi, Jie, et al.
Publicado: (2013)

Mechanism of Probiotic VSL#3 Inhibiting NF-κB and TNF-α on Colitis through TLR4-NF-κB Signal Pathway
por: WANG, Hui, et al.
Publicado: (2019)

Effect and Safety of Transcutaneous Auricular Vagus Nerve Stimulation on Recovery of Upper Limb Motor Function in Subacute Ischemic Stroke Patients: A Randomized Pilot Study
por: Wu, Dandong, et al.
Publicado: (2020)

ATM-NFκB axis-driven TIGAR regulates sensitivity of glioma cells to radiomimetics in the presence of TNFα
por: Sinha, S, et al.
Publicado: (2013)

Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy
por: Wang, Chao, et al.
Publicado: (2022)

Spontaneous NF-κB Activation by Autocrine TNFα Signaling: A Computational Analysis
por: Pękalski, Jakub, et al.
Publicado: (2013)

Does Enhanced External Counterpulsation (EECP) Significantly Affect Myocardial Perfusion?: A Systematic Review & Meta-Analysis
por: Qin, Xiaoxia, et al.
Publicado: (2016)

Kinetics of Leptin Binding to the Q223R Leptin Receptor
por: Verkerke, Hans, et al.
Publicado: (2014)

Leptin Inhibits Neutrophil Apoptosis in Children via ERK/NF-κB-Dependent Pathways
por: Sun, Zhizhi, et al.
Publicado: (2013)

TNF activation of NF-κB is essential for development of single-positive thymocytes
por: Webb, Louise V., et al.
Publicado: (2016)

HSCARG downregulates NF-κB signaling by interacting with USP7 and inhibiting NEMO ubiquitination
por: Li, T, et al.
Publicado: (2014)

Carbon monoxide prevents TNF-α-induced eNOS downregulation by inhibiting NF-κB-responsive miR-155-5p biogenesis
por: Choi, Seunghwan, et al.
Publicado: (2017)

NCOA2-induced secretion of leptin leads to fetal growth restriction via the NF-κB signaling pathway
por: Qu, Lin, et al.
Publicado: (2023)

DHZCP Modulates Microglial M1/M2 Polarization via the p38 and TLR4/NF-κB Signaling Pathways in LPS-Stimulated Microglial Cells
por: Zhou, Lu, et al.
Publicado: (2020)

Astrocyte galectin-9 potentiates microglial TNF secretion
por: Steelman, Andrew J, et al.
Publicado: (2014)

The dual effect of acetate on microglial TNF-α production
por: Fragas, Matheus Garcia, et al.
Publicado: (2022)

Sharpin Contributes to TNFα Dependent NFκB Activation and Anti-Apoptotic Signalling in Hepatocytes
por: Sieber, Sabrina, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_kr3n1brrf14nnoje0ao164n3iu