Cargando…

Interleukin-10 deficiency exacerbates inflammation-induced tau pathology

BACKGROUND: The presence of hyperphosphorylated microtubule-associated protein tau is strongly correlated with cognitive decline and neuroinflammation in Alzheimer’s disease and related tauopathies. However, the role of inflammation and anti-inflammatory interventions in tauopathies is unclear. Our...

Descripción completa

Detalles Bibliográficos
Autores principales:	Weston, Lea L., Jiang, Shanya, Chisholm, Devon, Jantzie, Lauren L., Bhaskar, Kiran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286621/ https://www.ncbi.nlm.nih.gov/pubmed/34275478 http://dx.doi.org/10.1186/s12974-021-02211-1

Ejemplares similares

Degradation and Transmission of Tau by Autophagic-Endolysosomal Networks and Potential Therapeutic Targets for Tauopathy
por: Jiang, Shanya, et al.
Publicado: (2020)

Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway
por: Jiang, Shanya, et al.
Publicado: (2021)

Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau Pathology
por: Maphis, Nicole M., et al.
Publicado: (2017)

Machine learning prediction and tau-based screening identifies potential Alzheimer’s disease genes relevant to immunity
por: Binder, Jessica, et al.
Publicado: (2022)

Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology
por: Maphis, Nicole, et al.
Publicado: (2016)

LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice
por: Lee, Daniel C, et al.
Publicado: (2010)

Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics
por: Woo, Jung-A. A., et al.
Publicado: (2019)

Phosphatase Shp2 exacerbates intestinal inflammation by disrupting macrophage responsiveness to interleukin-10
por: Xiao, Peng, et al.
Publicado: (2019)

TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy
por: Bemiller, Shane M., et al.
Publicado: (2017)

TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading
por: Xu, Yin, et al.
Publicado: (2021)

Loss of tau rescues inflammation-mediated neurodegeneration
por: Maphis, Nicole, et al.
Publicado: (2015)

Optical induction of autophagy via Transcription factor EB (TFEB) reduces pathological tau in neurons
por: Binder, Jessica L., et al.
Publicado: (2020)

Interleukin-10 Attenuates Liver Fibrosis Exacerbated by Thermoneutrality
por: Nga, Ha Thi, et al.
Publicado: (2021)

Interleukin-6 deficiency exacerbates Huntington’s disease model phenotypes
por: Wertz, Mary H., et al.
Publicado: (2020)

Viral Infection of the Central Nervous System Exacerbates Interleukin-10 Receptor Deficiency-Mediated Colitis in SJL Mice
por: Uhde, Ann-Kathrin, et al.
Publicado: (2016)

Association of Retromer Deficiency and Tau Pathology in Down Syndrome
por: Curtis, Mary Elizabeth, et al.
Publicado: (2022)

Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation
por: Barron, Matthew R., et al.
Publicado: (2020)

Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD mice
por: Farfara, Dorit, et al.
Publicado: (2023)

Caspase-1 deficiency reduces eosinophilia and interleukin-33 in an asthma exacerbation model
por: Menzel, Mandy, et al.
Publicado: (2017)

Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo
por: Stancu, Ilie-Cosmin, et al.
Publicado: (2019)

Akkermansia deficiency and mucin depletion are implicated in intestinal barrier dysfunction as earlier event in the development of inflammation in interleukin-10-deficient mice
por: López-Cauce, Beatriz, et al.
Publicado: (2023)

Experimental Diabetes Mellitus Exacerbates Tau Pathology in a Transgenic Mouse Model of Alzheimer's Disease
por: Ke, Yazi D., et al.
Publicado: (2009)

Accelerated aging exacerbates a pre‐existing pathology in a tau transgenic mouse model
por: Bodea, Liviu‐Gabriel, et al.
Publicado: (2017)

Collagen-induced arthritis is exacerbated in IL-10-deficient mice
por: Finnegan, Alison, et al.
Publicado: (2003)

Pathologic patterns of interleukin 10 expression – A review
por: Trifunović, Jasenka, et al.
Publicado: (2015)

Cannabinoid receptor 2 deficiency exacerbates inflammation and neutrophil recruitment
por: Kapellos, Theodore S., et al.
Publicado: (2019)

Deficiency of interleukin-19 exacerbates lipopolysaccharide/D-galactosamine-induced acute liver failure
por: FUJIMOTO, Yasuyuki, et al.
Publicado: (2020)

Dystrophin deficiency exacerbates skeletal muscle pathology in dysferlin-null mice
por: Han, Renzhi, et al.
Publicado: (2011)

Changes in Composition of Caecal Microbiota Associated with Increased Colon Inflammation in Interleukin-10 Gene-Deficient Mice Inoculated with Enterococcus Species
por: Bassett, Shalome A., et al.
Publicado: (2015)

Intravenous Injection of PHF-Tau Proteins From Alzheimer Brain Exacerbates Neuroinflammation, Amyloid Beta, and Tau Pathologies in 5XFAD Transgenic Mice
por: Houben, Sarah, et al.
Publicado: (2020)

Interleukin-32β Propagates Vascular Inflammation and Exacerbates Sepsis in a Mouse Model
por: Kobayashi, Hanako, et al.
Publicado: (2010)

Changes in colon gene expression associated with increased colon inflammation in interleukin-10 gene-deficient mice inoculated with Enterococcus species
por: Barnett, Matthew PG, et al.
Publicado: (2010)

Interleukin 33 exacerbates antigen driven airway hyperresponsiveness, inflammation and remodeling in a mouse model of asthma
por: Sjöberg, L. C., et al.
Publicado: (2017)

Interleukin33 deficiency causes tau abnormality and neurodegeneration with Alzheimer-like symptoms in aged mice
por: Carlock, C, et al.
Publicado: (2017)

Interleukin33 deficiency causes tau abnormality and neurodegeneration with Alzheimer-like symptoms in aged mice
por: Carlock, C, et al.
Publicado: (2017)

GFAP hyperpalmitoylation exacerbates astrogliosis and neurodegenerative pathology in PPT1-deficient mice
por: Yuan, Wei, et al.
Publicado: (2021)

Mitochondrial translocator protein deficiency exacerbates pathology in acute experimental ulcerative colitis
por: Jimenez, Isabel A., et al.
Publicado: (2022)

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation
por: Asseman, Chrystelle, et al.
Publicado: (1999)

Biomarkers for tau pathology
por: Schöll, Michael, et al.
Publicado: (2019)

Protective Role of Interleukin-10 in Ozone-Induced Pulmonary Inflammation
por: Backus, Gillian S., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_c3la2ash78k04hjede4legf9hs