Cargando…

Study of the Relationship between MMP-2 and MMP-9 and Her2/neu Overexpression in Gastric Cancer: Clinico-Pathological Correlations

BACKGROUND: The relationship between the expressions of matrix metalloproteinases with clinico-pathological data on gastric cancer has been investigated in many countries, but this relationship remains unexplored in Iranian patients. Also, the correlation of the MMPs and the HER-2/neu proto-oncogene...

Descripción completa

Detalles Bibliográficos
Autores principales: Jafari, Elham, Safinejad, Somaye, Dabiri, Shahriar, Naghibzadeh-Tahami, Ahmad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286688/
https://www.ncbi.nlm.nih.gov/pubmed/33773545
http://dx.doi.org/10.31557/APJCP.2021.22.3.811
_version_ 1783723764648771584
author Jafari, Elham
Safinejad, Somaye
Dabiri, Shahriar
Naghibzadeh-Tahami, Ahmad
author_facet Jafari, Elham
Safinejad, Somaye
Dabiri, Shahriar
Naghibzadeh-Tahami, Ahmad
author_sort Jafari, Elham
collection PubMed
description BACKGROUND: The relationship between the expressions of matrix metalloproteinases with clinico-pathological data on gastric cancer has been investigated in many countries, but this relationship remains unexplored in Iranian patients. Also, the correlation of the MMPs and the HER-2/neu proto-oncogene with other clinic-pathological variables has been evaluated for several other malignancies, but little effort has been made to shed light on the relationship with gastric cancer. METHODS: We investigated MMP-2 and MMP-9 expression and HERE-2/neu overexpression in 48 gastric cancer patients referred to Afzalipour Hospital, associated with Kerman Medical University. Immunohistochemistry staining with rabbit polyclonal antibodies was used. Data statistical analysis was done by SPSS software (Version 20.0). RESULTS: The mean age was 59, most of the patients were male (79.2%), and the average tumor size was larger than 5 centimeters in its greatest diameter. The majority of tumors were of the intestinal subtype and were located in the pyloric and antrum regions (43.8%). Invasion to muscularis properia was seen in 87.5% of the tumors (T3). MMP-2 and MMP-9 were highly expressed in 58.3% and 50% of cases, respectively, and Her-2/neu positivity was 10.4%. MMP-2, MMP-9 and HER-2 were found to have no relation with any clinicopathological parameters. CONCLUSION: According to the results of this study, MMP-2 and MMP-9 were highly expressed in gastric cancer, but there was no significant association with other clinicopathological variables.
format Online
Article
Text
id pubmed-8286688
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher West Asia Organization for Cancer Prevention
record_format MEDLINE/PubMed
spelling pubmed-82866882021-07-23 Study of the Relationship between MMP-2 and MMP-9 and Her2/neu Overexpression in Gastric Cancer: Clinico-Pathological Correlations Jafari, Elham Safinejad, Somaye Dabiri, Shahriar Naghibzadeh-Tahami, Ahmad Asian Pac J Cancer Prev Research Article BACKGROUND: The relationship between the expressions of matrix metalloproteinases with clinico-pathological data on gastric cancer has been investigated in many countries, but this relationship remains unexplored in Iranian patients. Also, the correlation of the MMPs and the HER-2/neu proto-oncogene with other clinic-pathological variables has been evaluated for several other malignancies, but little effort has been made to shed light on the relationship with gastric cancer. METHODS: We investigated MMP-2 and MMP-9 expression and HERE-2/neu overexpression in 48 gastric cancer patients referred to Afzalipour Hospital, associated with Kerman Medical University. Immunohistochemistry staining with rabbit polyclonal antibodies was used. Data statistical analysis was done by SPSS software (Version 20.0). RESULTS: The mean age was 59, most of the patients were male (79.2%), and the average tumor size was larger than 5 centimeters in its greatest diameter. The majority of tumors were of the intestinal subtype and were located in the pyloric and antrum regions (43.8%). Invasion to muscularis properia was seen in 87.5% of the tumors (T3). MMP-2 and MMP-9 were highly expressed in 58.3% and 50% of cases, respectively, and Her-2/neu positivity was 10.4%. MMP-2, MMP-9 and HER-2 were found to have no relation with any clinicopathological parameters. CONCLUSION: According to the results of this study, MMP-2 and MMP-9 were highly expressed in gastric cancer, but there was no significant association with other clinicopathological variables. West Asia Organization for Cancer Prevention 2021-03 /pmc/articles/PMC8286688/ /pubmed/33773545 http://dx.doi.org/10.31557/APJCP.2021.22.3.811 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Jafari, Elham
Safinejad, Somaye
Dabiri, Shahriar
Naghibzadeh-Tahami, Ahmad
Study of the Relationship between MMP-2 and MMP-9 and Her2/neu Overexpression in Gastric Cancer: Clinico-Pathological Correlations
title Study of the Relationship between MMP-2 and MMP-9 and Her2/neu Overexpression in Gastric Cancer: Clinico-Pathological Correlations
title_full Study of the Relationship between MMP-2 and MMP-9 and Her2/neu Overexpression in Gastric Cancer: Clinico-Pathological Correlations
title_fullStr Study of the Relationship between MMP-2 and MMP-9 and Her2/neu Overexpression in Gastric Cancer: Clinico-Pathological Correlations
title_full_unstemmed Study of the Relationship between MMP-2 and MMP-9 and Her2/neu Overexpression in Gastric Cancer: Clinico-Pathological Correlations
title_short Study of the Relationship between MMP-2 and MMP-9 and Her2/neu Overexpression in Gastric Cancer: Clinico-Pathological Correlations
title_sort study of the relationship between mmp-2 and mmp-9 and her2/neu overexpression in gastric cancer: clinico-pathological correlations
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286688/
https://www.ncbi.nlm.nih.gov/pubmed/33773545
http://dx.doi.org/10.31557/APJCP.2021.22.3.811
work_keys_str_mv AT jafarielham studyoftherelationshipbetweenmmp2andmmp9andher2neuoverexpressioningastriccancerclinicopathologicalcorrelations
AT safinejadsomaye studyoftherelationshipbetweenmmp2andmmp9andher2neuoverexpressioningastriccancerclinicopathologicalcorrelations
AT dabirishahriar studyoftherelationshipbetweenmmp2andmmp9andher2neuoverexpressioningastriccancerclinicopathologicalcorrelations
AT naghibzadehtahamiahmad studyoftherelationshipbetweenmmp2andmmp9andher2neuoverexpressioningastriccancerclinicopathologicalcorrelations