IQGAP3 May Serve as a Promising Biomarker in Clear Cell Renal Cell Carcinoma

AIM: The study was designed to mine the expression and roles of IQGAP3 in clear cell renal cell carcinoma (ccRCC). METHODS: Expression profiles and clinical information were obtained from the Cancer Genome Atlas (TCGA) to estimate IQGAP3 expression in ccRCC, its relationship with patients’ clinicopa...

Descripción completa

Detalles Bibliográficos
Autores principales: Meng, Quan, Li, Can-Xuan, Long, Dan, Lin, Xiaobin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286744/
https://www.ncbi.nlm.nih.gov/pubmed/34285569
http://dx.doi.org/10.2147/IJGM.S316280
_version_ 1783723776208273408
author Meng, Quan
Li, Can-Xuan
Long, Dan
Lin, Xiaobin
author_facet Meng, Quan
Li, Can-Xuan
Long, Dan
Lin, Xiaobin
author_sort Meng, Quan
collection PubMed
description AIM: The study was designed to mine the expression and roles of IQGAP3 in clear cell renal cell carcinoma (ccRCC). METHODS: Expression profiles and clinical information were obtained from the Cancer Genome Atlas (TCGA) to estimate IQGAP3 expression in ccRCC, its relationship with patients’ clinicopathological variables and prognosis, and the potential biological mechanisms. RESULTS: IQGAP3 was highly expressed in ccRCC and indicated advanced clinical outcome and poor prognosis. IQGAP3 affected the progression of ccRCC through several cancer-related pathways. IQGAP3 might play a vital role in the ccRCC tumor microenvironment. CONCLUSION: IQGAP3 could serve as a promising prognostic biomarker and therapeutic target.
format Online
Article
Text
id pubmed-8286744
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-82867442021-07-19 IQGAP3 May Serve as a Promising Biomarker in Clear Cell Renal Cell Carcinoma Meng, Quan Li, Can-Xuan Long, Dan Lin, Xiaobin Int J Gen Med Original Research AIM: The study was designed to mine the expression and roles of IQGAP3 in clear cell renal cell carcinoma (ccRCC). METHODS: Expression profiles and clinical information were obtained from the Cancer Genome Atlas (TCGA) to estimate IQGAP3 expression in ccRCC, its relationship with patients’ clinicopathological variables and prognosis, and the potential biological mechanisms. RESULTS: IQGAP3 was highly expressed in ccRCC and indicated advanced clinical outcome and poor prognosis. IQGAP3 affected the progression of ccRCC through several cancer-related pathways. IQGAP3 might play a vital role in the ccRCC tumor microenvironment. CONCLUSION: IQGAP3 could serve as a promising prognostic biomarker and therapeutic target. Dove 2021-07-14 /pmc/articles/PMC8286744/ /pubmed/34285569 http://dx.doi.org/10.2147/IJGM.S316280 Text en © 2021 Meng et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Meng, Quan
Li, Can-Xuan
Long, Dan
Lin, Xiaobin
IQGAP3 May Serve as a Promising Biomarker in Clear Cell Renal Cell Carcinoma
title IQGAP3 May Serve as a Promising Biomarker in Clear Cell Renal Cell Carcinoma
title_full IQGAP3 May Serve as a Promising Biomarker in Clear Cell Renal Cell Carcinoma
title_fullStr IQGAP3 May Serve as a Promising Biomarker in Clear Cell Renal Cell Carcinoma
title_full_unstemmed IQGAP3 May Serve as a Promising Biomarker in Clear Cell Renal Cell Carcinoma
title_short IQGAP3 May Serve as a Promising Biomarker in Clear Cell Renal Cell Carcinoma
title_sort iqgap3 may serve as a promising biomarker in clear cell renal cell carcinoma
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286744/
https://www.ncbi.nlm.nih.gov/pubmed/34285569
http://dx.doi.org/10.2147/IJGM.S316280
work_keys_str_mv AT mengquan iqgap3mayserveasapromisingbiomarkerinclearcellrenalcellcarcinoma
AT licanxuan iqgap3mayserveasapromisingbiomarkerinclearcellrenalcellcarcinoma
AT longdan iqgap3mayserveasapromisingbiomarkerinclearcellrenalcellcarcinoma
AT linxiaobin iqgap3mayserveasapromisingbiomarkerinclearcellrenalcellcarcinoma

Ejemplares similares