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Mitochondrial malic enzyme 2 promotes breast cancer metastasis via stabilizing HIF-1α under hypoxia

OBJECTIVE: α-ketoglutarate (α-KG) is the substrate to hydroxylate collagen and hypoxia-inducible factor-1α (HIF-1α), which are important for cancer metastasis. Previous studies have shown that the upregulation of collagen prolyl 4-hydroxylase in breast cancer cells stabilizes the expression of HIF-1...

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Detalles Bibliográficos
Autores principales:	You, Duo, Du, Danfeng, Zhao, Xueke, Li, Xinmin, Ying, Minfeng, Hu, Xun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286887/ https://www.ncbi.nlm.nih.gov/pubmed/34321828 http://dx.doi.org/10.21147/j.issn.1000-9604.2021.03.03

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