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Is (70)Zn(d,x)(67)Cu the Best Way to Produce (67)Cu for Medical Applications?

The pair of copper radionuclides (64)Cu/(67)Cu (T(1/2) = 12. 7 h/61.8 h) allows, respectively, PET imaging and targeted beta therapy. An analysis of the different production routes of (67)Cu with charged particles was performed and the reaction (70)Zn(d,x) route was identified as a promising one. It...

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Autores principales: Nigron, Etienne, Guertin, Arnaud, Haddad, Ferid, Sounalet, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287065/
https://www.ncbi.nlm.nih.gov/pubmed/34291060
http://dx.doi.org/10.3389/fmed.2021.674617
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author Nigron, Etienne
Guertin, Arnaud
Haddad, Ferid
Sounalet, Thomas
author_facet Nigron, Etienne
Guertin, Arnaud
Haddad, Ferid
Sounalet, Thomas
author_sort Nigron, Etienne
collection PubMed
description The pair of copper radionuclides (64)Cu/(67)Cu (T(1/2) = 12. 7 h/61.8 h) allows, respectively, PET imaging and targeted beta therapy. An analysis of the different production routes of (67)Cu with charged particles was performed and the reaction (70)Zn(d,x) route was identified as a promising one. It may allow the production of (67)Cu without (64)Cu. The production cross section has been measured up to 28.7 MeV. Measurements were done using the well-known stacked-foils technique using 97.5% enriched (70)Zn homemade electroplated targets. These measurements complement at higher incident energies the only set of data available in nuclear databases. The results show that using a 26 MeV deuteron beam and a highly enriched (70)Zn target, it is possible to produce high purity (67)Cu comparable to that obtained using photoproduction. This production route can be of interest for future linear accelerators under development where mA deuteron beams can be available if adequate targetry is developed.
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spelling pubmed-82870652021-07-20 Is (70)Zn(d,x)(67)Cu the Best Way to Produce (67)Cu for Medical Applications? Nigron, Etienne Guertin, Arnaud Haddad, Ferid Sounalet, Thomas Front Med (Lausanne) Medicine The pair of copper radionuclides (64)Cu/(67)Cu (T(1/2) = 12. 7 h/61.8 h) allows, respectively, PET imaging and targeted beta therapy. An analysis of the different production routes of (67)Cu with charged particles was performed and the reaction (70)Zn(d,x) route was identified as a promising one. It may allow the production of (67)Cu without (64)Cu. The production cross section has been measured up to 28.7 MeV. Measurements were done using the well-known stacked-foils technique using 97.5% enriched (70)Zn homemade electroplated targets. These measurements complement at higher incident energies the only set of data available in nuclear databases. The results show that using a 26 MeV deuteron beam and a highly enriched (70)Zn target, it is possible to produce high purity (67)Cu comparable to that obtained using photoproduction. This production route can be of interest for future linear accelerators under development where mA deuteron beams can be available if adequate targetry is developed. Frontiers Media S.A. 2021-07-05 /pmc/articles/PMC8287065/ /pubmed/34291060 http://dx.doi.org/10.3389/fmed.2021.674617 Text en Copyright © 2021 Nigron, Guertin, Haddad and Sounalet. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Nigron, Etienne
Guertin, Arnaud
Haddad, Ferid
Sounalet, Thomas
Is (70)Zn(d,x)(67)Cu the Best Way to Produce (67)Cu for Medical Applications?
title Is (70)Zn(d,x)(67)Cu the Best Way to Produce (67)Cu for Medical Applications?
title_full Is (70)Zn(d,x)(67)Cu the Best Way to Produce (67)Cu for Medical Applications?
title_fullStr Is (70)Zn(d,x)(67)Cu the Best Way to Produce (67)Cu for Medical Applications?
title_full_unstemmed Is (70)Zn(d,x)(67)Cu the Best Way to Produce (67)Cu for Medical Applications?
title_short Is (70)Zn(d,x)(67)Cu the Best Way to Produce (67)Cu for Medical Applications?
title_sort is (70)zn(d,x)(67)cu the best way to produce (67)cu for medical applications?
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287065/
https://www.ncbi.nlm.nih.gov/pubmed/34291060
http://dx.doi.org/10.3389/fmed.2021.674617
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