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Developments and Opportunities for 3D Bioprinted Organoids

Organoids developed from pluripotent stem cells or adult stem cells are three-dimensional cell cultures possessing certain key characteristics of their organ counterparts, and they can mimic certain biological developmental processes of organs in vitro. Therefore, they have promising applications in...

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Autores principales: Ren, Ya, Yang, Xue, Ma, Zhengjiang, Sun, Xin, Zhang, Yuxin, Li, Wentao, Yang, Han, Qiang, Lei, Yang, Zezheng, Liu, Yihao, Deng, Changxu, Zhou, Liang, Wang, Tianchang, Lin, Jingsheng, Li, Tao, Wu, Tao, Wang, Jinwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Whioce Publishing Pte. Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287496/
https://www.ncbi.nlm.nih.gov/pubmed/34286150
http://dx.doi.org/10.18063/ijb.v7i3.364
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author Ren, Ya
Yang, Xue
Ma, Zhengjiang
Sun, Xin
Zhang, Yuxin
Li, Wentao
Yang, Han
Qiang, Lei
Yang, Zezheng
Liu, Yihao
Deng, Changxu
Zhou, Liang
Wang, Tianchang
Lin, Jingsheng
Li, Tao
Wu, Tao
Wang, Jinwu
author_facet Ren, Ya
Yang, Xue
Ma, Zhengjiang
Sun, Xin
Zhang, Yuxin
Li, Wentao
Yang, Han
Qiang, Lei
Yang, Zezheng
Liu, Yihao
Deng, Changxu
Zhou, Liang
Wang, Tianchang
Lin, Jingsheng
Li, Tao
Wu, Tao
Wang, Jinwu
author_sort Ren, Ya
collection PubMed
description Organoids developed from pluripotent stem cells or adult stem cells are three-dimensional cell cultures possessing certain key characteristics of their organ counterparts, and they can mimic certain biological developmental processes of organs in vitro. Therefore, they have promising applications in drug screening, disease modeling, and regenerative repair of tissues and organs. However, the construction of organoids currently faces numerous challenges, such as breakthroughs in scale size, vascularization, better reproducibility, and precise architecture in time and space. Recently, the application of bioprinting has accelerated the process of organoid construction. In this review, we present current bioprinting techniques and the application of bioinks and summarize examples of successful organoid bioprinting. In the future, a multidisciplinary combination of developmental biology, disease pathology, cell biology, and materials science will aid in overcoming the obstacles pertaining to the bioprinting of organoids. The combination of bioprinting and organoids with a focus on structure and function can facilitate further development of real organs.
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spelling pubmed-82874962021-07-19 Developments and Opportunities for 3D Bioprinted Organoids Ren, Ya Yang, Xue Ma, Zhengjiang Sun, Xin Zhang, Yuxin Li, Wentao Yang, Han Qiang, Lei Yang, Zezheng Liu, Yihao Deng, Changxu Zhou, Liang Wang, Tianchang Lin, Jingsheng Li, Tao Wu, Tao Wang, Jinwu Int J Bioprint Review Article Organoids developed from pluripotent stem cells or adult stem cells are three-dimensional cell cultures possessing certain key characteristics of their organ counterparts, and they can mimic certain biological developmental processes of organs in vitro. Therefore, they have promising applications in drug screening, disease modeling, and regenerative repair of tissues and organs. However, the construction of organoids currently faces numerous challenges, such as breakthroughs in scale size, vascularization, better reproducibility, and precise architecture in time and space. Recently, the application of bioprinting has accelerated the process of organoid construction. In this review, we present current bioprinting techniques and the application of bioinks and summarize examples of successful organoid bioprinting. In the future, a multidisciplinary combination of developmental biology, disease pathology, cell biology, and materials science will aid in overcoming the obstacles pertaining to the bioprinting of organoids. The combination of bioprinting and organoids with a focus on structure and function can facilitate further development of real organs. Whioce Publishing Pte. Ltd. 2021-06-28 /pmc/articles/PMC8287496/ /pubmed/34286150 http://dx.doi.org/10.18063/ijb.v7i3.364 Text en Copyright: © 2021 Ren, et al. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Attribution-NonCommercial 4.0 International 4.0 (CC BY-NC 4.0), which permits all non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited.
spellingShingle Review Article
Ren, Ya
Yang, Xue
Ma, Zhengjiang
Sun, Xin
Zhang, Yuxin
Li, Wentao
Yang, Han
Qiang, Lei
Yang, Zezheng
Liu, Yihao
Deng, Changxu
Zhou, Liang
Wang, Tianchang
Lin, Jingsheng
Li, Tao
Wu, Tao
Wang, Jinwu
Developments and Opportunities for 3D Bioprinted Organoids
title Developments and Opportunities for 3D Bioprinted Organoids
title_full Developments and Opportunities for 3D Bioprinted Organoids
title_fullStr Developments and Opportunities for 3D Bioprinted Organoids
title_full_unstemmed Developments and Opportunities for 3D Bioprinted Organoids
title_short Developments and Opportunities for 3D Bioprinted Organoids
title_sort developments and opportunities for 3d bioprinted organoids
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287496/
https://www.ncbi.nlm.nih.gov/pubmed/34286150
http://dx.doi.org/10.18063/ijb.v7i3.364
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