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Developments and Opportunities for 3D Bioprinted Organoids
Organoids developed from pluripotent stem cells or adult stem cells are three-dimensional cell cultures possessing certain key characteristics of their organ counterparts, and they can mimic certain biological developmental processes of organs in vitro. Therefore, they have promising applications in...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Whioce Publishing Pte. Ltd.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287496/ https://www.ncbi.nlm.nih.gov/pubmed/34286150 http://dx.doi.org/10.18063/ijb.v7i3.364 |
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author | Ren, Ya Yang, Xue Ma, Zhengjiang Sun, Xin Zhang, Yuxin Li, Wentao Yang, Han Qiang, Lei Yang, Zezheng Liu, Yihao Deng, Changxu Zhou, Liang Wang, Tianchang Lin, Jingsheng Li, Tao Wu, Tao Wang, Jinwu |
author_facet | Ren, Ya Yang, Xue Ma, Zhengjiang Sun, Xin Zhang, Yuxin Li, Wentao Yang, Han Qiang, Lei Yang, Zezheng Liu, Yihao Deng, Changxu Zhou, Liang Wang, Tianchang Lin, Jingsheng Li, Tao Wu, Tao Wang, Jinwu |
author_sort | Ren, Ya |
collection | PubMed |
description | Organoids developed from pluripotent stem cells or adult stem cells are three-dimensional cell cultures possessing certain key characteristics of their organ counterparts, and they can mimic certain biological developmental processes of organs in vitro. Therefore, they have promising applications in drug screening, disease modeling, and regenerative repair of tissues and organs. However, the construction of organoids currently faces numerous challenges, such as breakthroughs in scale size, vascularization, better reproducibility, and precise architecture in time and space. Recently, the application of bioprinting has accelerated the process of organoid construction. In this review, we present current bioprinting techniques and the application of bioinks and summarize examples of successful organoid bioprinting. In the future, a multidisciplinary combination of developmental biology, disease pathology, cell biology, and materials science will aid in overcoming the obstacles pertaining to the bioprinting of organoids. The combination of bioprinting and organoids with a focus on structure and function can facilitate further development of real organs. |
format | Online Article Text |
id | pubmed-8287496 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Whioce Publishing Pte. Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82874962021-07-19 Developments and Opportunities for 3D Bioprinted Organoids Ren, Ya Yang, Xue Ma, Zhengjiang Sun, Xin Zhang, Yuxin Li, Wentao Yang, Han Qiang, Lei Yang, Zezheng Liu, Yihao Deng, Changxu Zhou, Liang Wang, Tianchang Lin, Jingsheng Li, Tao Wu, Tao Wang, Jinwu Int J Bioprint Review Article Organoids developed from pluripotent stem cells or adult stem cells are three-dimensional cell cultures possessing certain key characteristics of their organ counterparts, and they can mimic certain biological developmental processes of organs in vitro. Therefore, they have promising applications in drug screening, disease modeling, and regenerative repair of tissues and organs. However, the construction of organoids currently faces numerous challenges, such as breakthroughs in scale size, vascularization, better reproducibility, and precise architecture in time and space. Recently, the application of bioprinting has accelerated the process of organoid construction. In this review, we present current bioprinting techniques and the application of bioinks and summarize examples of successful organoid bioprinting. In the future, a multidisciplinary combination of developmental biology, disease pathology, cell biology, and materials science will aid in overcoming the obstacles pertaining to the bioprinting of organoids. The combination of bioprinting and organoids with a focus on structure and function can facilitate further development of real organs. Whioce Publishing Pte. Ltd. 2021-06-28 /pmc/articles/PMC8287496/ /pubmed/34286150 http://dx.doi.org/10.18063/ijb.v7i3.364 Text en Copyright: © 2021 Ren, et al. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Attribution-NonCommercial 4.0 International 4.0 (CC BY-NC 4.0), which permits all non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited. |
spellingShingle | Review Article Ren, Ya Yang, Xue Ma, Zhengjiang Sun, Xin Zhang, Yuxin Li, Wentao Yang, Han Qiang, Lei Yang, Zezheng Liu, Yihao Deng, Changxu Zhou, Liang Wang, Tianchang Lin, Jingsheng Li, Tao Wu, Tao Wang, Jinwu Developments and Opportunities for 3D Bioprinted Organoids |
title | Developments and Opportunities for 3D Bioprinted Organoids |
title_full | Developments and Opportunities for 3D Bioprinted Organoids |
title_fullStr | Developments and Opportunities for 3D Bioprinted Organoids |
title_full_unstemmed | Developments and Opportunities for 3D Bioprinted Organoids |
title_short | Developments and Opportunities for 3D Bioprinted Organoids |
title_sort | developments and opportunities for 3d bioprinted organoids |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287496/ https://www.ncbi.nlm.nih.gov/pubmed/34286150 http://dx.doi.org/10.18063/ijb.v7i3.364 |
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