Interplay between hypoxia and inflammation contributes to the progression and severity of respiratory viral diseases

History of pandemics is dominated by viral infections and specifically respiratory viral diseases like influenza and COVID-19. Lower respiratory tract infection is the fourth leading cause of death worldwide. Crosstalk between resultant inflammation and hypoxic microenvironment may impair ventilator...

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Autores principales: Bhattacharya, Sulagna, Agarwal, Sakshi, Shrimali, Nishith M., Guchhait, Prasenjit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287505/
https://www.ncbi.nlm.nih.gov/pubmed/34294412
http://dx.doi.org/10.1016/j.mam.2021.101000
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author Bhattacharya, Sulagna
Agarwal, Sakshi
Shrimali, Nishith M.
Guchhait, Prasenjit
author_facet Bhattacharya, Sulagna
Agarwal, Sakshi
Shrimali, Nishith M.
Guchhait, Prasenjit
author_sort Bhattacharya, Sulagna
collection PubMed
description History of pandemics is dominated by viral infections and specifically respiratory viral diseases like influenza and COVID-19. Lower respiratory tract infection is the fourth leading cause of death worldwide. Crosstalk between resultant inflammation and hypoxic microenvironment may impair ventilatory response of lungs. This reduces arterial partial pressure of oxygen, termed as hypoxemia, which is observed in a section of patients with respiratory virus infections including SARS-CoV-2 (COVID-19). In this review, we describe the interplay between inflammation and hypoxic microenvironment in respiratory viral infection and its contribution to disease pathogenesis.
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spelling pubmed-82875052021-07-20 Interplay between hypoxia and inflammation contributes to the progression and severity of respiratory viral diseases Bhattacharya, Sulagna Agarwal, Sakshi Shrimali, Nishith M. Guchhait, Prasenjit Mol Aspects Med Article History of pandemics is dominated by viral infections and specifically respiratory viral diseases like influenza and COVID-19. Lower respiratory tract infection is the fourth leading cause of death worldwide. Crosstalk between resultant inflammation and hypoxic microenvironment may impair ventilatory response of lungs. This reduces arterial partial pressure of oxygen, termed as hypoxemia, which is observed in a section of patients with respiratory virus infections including SARS-CoV-2 (COVID-19). In this review, we describe the interplay between inflammation and hypoxic microenvironment in respiratory viral infection and its contribution to disease pathogenesis. Elsevier Ltd. 2021-10 2021-07-19 /pmc/articles/PMC8287505/ /pubmed/34294412 http://dx.doi.org/10.1016/j.mam.2021.101000 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Bhattacharya, Sulagna
Agarwal, Sakshi
Shrimali, Nishith M.
Guchhait, Prasenjit
Interplay between hypoxia and inflammation contributes to the progression and severity of respiratory viral diseases
title Interplay between hypoxia and inflammation contributes to the progression and severity of respiratory viral diseases
title_full Interplay between hypoxia and inflammation contributes to the progression and severity of respiratory viral diseases
title_fullStr Interplay between hypoxia and inflammation contributes to the progression and severity of respiratory viral diseases
title_full_unstemmed Interplay between hypoxia and inflammation contributes to the progression and severity of respiratory viral diseases
title_short Interplay between hypoxia and inflammation contributes to the progression and severity of respiratory viral diseases
title_sort interplay between hypoxia and inflammation contributes to the progression and severity of respiratory viral diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287505/
https://www.ncbi.nlm.nih.gov/pubmed/34294412
http://dx.doi.org/10.1016/j.mam.2021.101000
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