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Quadriceps muscle power and optimal shortening velocity are inversely related to angiotensin converting enzyme activity in older men

Background: Methods which potentially could prevent age-related loss of muscle mass and function are still being sought. There are various attempts to use pharmacological agents to prevent loss of muscle mass, but the effectiveness of many of them still needs to be confirmed. One of the promising th...

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Autores principales: Kostka, Joanna, Sikora, Joanna, Guligowska, Agnieszka, Kostka, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287535/
https://www.ncbi.nlm.nih.gov/pubmed/34354813
http://dx.doi.org/10.12688/f1000research.51208.2
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author Kostka, Joanna
Sikora, Joanna
Guligowska, Agnieszka
Kostka, Tomasz
author_facet Kostka, Joanna
Sikora, Joanna
Guligowska, Agnieszka
Kostka, Tomasz
author_sort Kostka, Joanna
collection PubMed
description Background: Methods which potentially could prevent age-related loss of muscle mass and function are still being sought. There are various attempts to use pharmacological agents to prevent loss of muscle mass, but the effectiveness of many of them still needs to be confirmed. One of the promising therapeutics are Angiotensin Converting Enzyme Inhibitors (ACEIs) and lowering of serum ACE activity. The goal of this study was to assess if taking Angiotensin Converting Enzyme Inhibitors (ACEI) and other angiotensin system blocking medications (ASBMs) can modify muscle performance in older men as well as to assess the association of serum ACE activity with muscle strength, power, muscle contraction velocity and functional performance. Methods: Seventy-nine older men took part in the study. Muscle function was assessed with hand grip strength, maximum power relative to body mass (Pmax) and optimal shortening velocity (Ʋopt) of the knee extensor muscles. Anthropometric data, ACE activity and functional performance were also measured. Results: Negative correlations between ACE activity and Pmax (rho=-0.29, p=0.04) as well as Ʋopt  (rho=-0.31, p=0.03) in a group of patients not taking ACEI and between ACE activity and Ʋopt (rho=-0.22, p=0.05) in the whole group of men were found. Positive relationship between age and ACE activity was demonstrated (rho=0.26, p=0.02). Age was the only selected variable in the multiple regression analyses to determine both Pmax and Ʋopt. Conclusions: Serum ACE activity negatively associates to muscle power and muscle contraction velocity. The issues related to the impact of taking ACEI on the maintenance of muscle function and functional performance in older man require further studies.
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spelling pubmed-82875352021-08-04 Quadriceps muscle power and optimal shortening velocity are inversely related to angiotensin converting enzyme activity in older men Kostka, Joanna Sikora, Joanna Guligowska, Agnieszka Kostka, Tomasz F1000Res Research Article Background: Methods which potentially could prevent age-related loss of muscle mass and function are still being sought. There are various attempts to use pharmacological agents to prevent loss of muscle mass, but the effectiveness of many of them still needs to be confirmed. One of the promising therapeutics are Angiotensin Converting Enzyme Inhibitors (ACEIs) and lowering of serum ACE activity. The goal of this study was to assess if taking Angiotensin Converting Enzyme Inhibitors (ACEI) and other angiotensin system blocking medications (ASBMs) can modify muscle performance in older men as well as to assess the association of serum ACE activity with muscle strength, power, muscle contraction velocity and functional performance. Methods: Seventy-nine older men took part in the study. Muscle function was assessed with hand grip strength, maximum power relative to body mass (Pmax) and optimal shortening velocity (Ʋopt) of the knee extensor muscles. Anthropometric data, ACE activity and functional performance were also measured. Results: Negative correlations between ACE activity and Pmax (rho=-0.29, p=0.04) as well as Ʋopt  (rho=-0.31, p=0.03) in a group of patients not taking ACEI and between ACE activity and Ʋopt (rho=-0.22, p=0.05) in the whole group of men were found. Positive relationship between age and ACE activity was demonstrated (rho=0.26, p=0.02). Age was the only selected variable in the multiple regression analyses to determine both Pmax and Ʋopt. Conclusions: Serum ACE activity negatively associates to muscle power and muscle contraction velocity. The issues related to the impact of taking ACEI on the maintenance of muscle function and functional performance in older man require further studies. F1000 Research Limited 2021-06-09 /pmc/articles/PMC8287535/ /pubmed/34354813 http://dx.doi.org/10.12688/f1000research.51208.2 Text en Copyright: © 2021 Kostka J et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kostka, Joanna
Sikora, Joanna
Guligowska, Agnieszka
Kostka, Tomasz
Quadriceps muscle power and optimal shortening velocity are inversely related to angiotensin converting enzyme activity in older men
title Quadriceps muscle power and optimal shortening velocity are inversely related to angiotensin converting enzyme activity in older men
title_full Quadriceps muscle power and optimal shortening velocity are inversely related to angiotensin converting enzyme activity in older men
title_fullStr Quadriceps muscle power and optimal shortening velocity are inversely related to angiotensin converting enzyme activity in older men
title_full_unstemmed Quadriceps muscle power and optimal shortening velocity are inversely related to angiotensin converting enzyme activity in older men
title_short Quadriceps muscle power and optimal shortening velocity are inversely related to angiotensin converting enzyme activity in older men
title_sort quadriceps muscle power and optimal shortening velocity are inversely related to angiotensin converting enzyme activity in older men
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287535/
https://www.ncbi.nlm.nih.gov/pubmed/34354813
http://dx.doi.org/10.12688/f1000research.51208.2
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