MICAL2 fine-tunes Arp2/3 for actin branching

The ARP2/3 complex promotes branched actin networks, but the importance of specific subunit isoforms is unclear. In this issue, Galloni, Carra, et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202102043) show that MICAL2 mediates methionine oxidation of ARP3B, thus destabilizing ARP2/3 comple...

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Detalles Bibliográficos
Autores principales: Olson, Michael F., Machesky, Laura M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287539/
https://www.ncbi.nlm.nih.gov/pubmed/34264264
http://dx.doi.org/10.1083/jcb.202106176
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author Olson, Michael F.
Machesky, Laura M.
author_facet Olson, Michael F.
Machesky, Laura M.
author_sort Olson, Michael F.
collection PubMed
description The ARP2/3 complex promotes branched actin networks, but the importance of specific subunit isoforms is unclear. In this issue, Galloni, Carra, et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202102043) show that MICAL2 mediates methionine oxidation of ARP3B, thus destabilizing ARP2/3 complexes and leading to disassembly of branched actin filaments.
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spelling pubmed-82875392022-02-02 MICAL2 fine-tunes Arp2/3 for actin branching Olson, Michael F. Machesky, Laura M. J Cell Biol Spotlight The ARP2/3 complex promotes branched actin networks, but the importance of specific subunit isoforms is unclear. In this issue, Galloni, Carra, et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202102043) show that MICAL2 mediates methionine oxidation of ARP3B, thus destabilizing ARP2/3 complexes and leading to disassembly of branched actin filaments. Rockefeller University Press 2021-07-15 /pmc/articles/PMC8287539/ /pubmed/34264264 http://dx.doi.org/10.1083/jcb.202106176 Text en © 2021 Olson and Machesky http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
Olson, Michael F.
Machesky, Laura M.
MICAL2 fine-tunes Arp2/3 for actin branching
title MICAL2 fine-tunes Arp2/3 for actin branching
title_full MICAL2 fine-tunes Arp2/3 for actin branching
title_fullStr MICAL2 fine-tunes Arp2/3 for actin branching
title_full_unstemmed MICAL2 fine-tunes Arp2/3 for actin branching
title_short MICAL2 fine-tunes Arp2/3 for actin branching
title_sort mical2 fine-tunes arp2/3 for actin branching
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287539/
https://www.ncbi.nlm.nih.gov/pubmed/34264264
http://dx.doi.org/10.1083/jcb.202106176
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AT macheskylauram mical2finetunesarp23foractinbranching

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