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Metal organic framework-coated gold nanorod as an on-demand drug delivery platform for chemo-photothermal cancer therapy

Chemo-photothermal therapy based on nanoparticles has emerged as a promising strategy for cancer treatment. However, its therapeutic efficacy and application potential are largely subjected to the uncontrollability and biotoxicity of functional nanoplatforms. Herein, a novel biocompatible and biodeg...

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Autores principales: Huang, Junfeng, Xu, Zhourui, jiang, Yihang, Law, Wing-cheung, Dong, Biqin, Zeng, Xierong, Ma, Mingze, Xu, Gaixia, Zou, Jizhao, Yang, Chengbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287674/
https://www.ncbi.nlm.nih.gov/pubmed/34281545
http://dx.doi.org/10.1186/s12951-021-00961-x
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author Huang, Junfeng
Xu, Zhourui
jiang, Yihang
Law, Wing-cheung
Dong, Biqin
Zeng, Xierong
Ma, Mingze
Xu, Gaixia
Zou, Jizhao
Yang, Chengbin
author_facet Huang, Junfeng
Xu, Zhourui
jiang, Yihang
Law, Wing-cheung
Dong, Biqin
Zeng, Xierong
Ma, Mingze
Xu, Gaixia
Zou, Jizhao
Yang, Chengbin
author_sort Huang, Junfeng
collection PubMed
description Chemo-photothermal therapy based on nanoparticles has emerged as a promising strategy for cancer treatment. However, its therapeutic efficacy and application potential are largely subjected to the uncontrollability and biotoxicity of functional nanoplatforms. Herein, a novel biocompatible and biodegradable metal organic framework (MOF), which was constructed by growing crystalline zeolitic imidazolate framework-8 on gold nanoroad (Au@ZIF-8), was designed and fabricated for efficient drug loading and controlled release. Owing to the large surface area and guest-matching pore size of ZIF-8, doxorubicin (DOX) was successfully loaded into the Au@ZIF-8 with a high drug loading efficiency of ~ 37%. Under NIR light or weakly acidic environment, the ZIF-8 layer was quickly degraded, which resulted in an on-demand drug release in tumour site. More importantly, under the irradiation of near infrared (NIR) laser, highly efficient cancer treatment was achieved in both in vitro cell experiment and in vivo tumour-bearing nude mice experiment due to the synergistic effect of photothermal (PTT) therapy and chemotherapy. In addition, the in vivo study revealed the good biocompatibility of Au@ZIF-8. This work robustly suggested that Au@ZIF-8 could be further explored as a drug delivery system for chemo-photothermal synergistic therapy. [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-021-00961-x.
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spelling pubmed-82876742021-07-19 Metal organic framework-coated gold nanorod as an on-demand drug delivery platform for chemo-photothermal cancer therapy Huang, Junfeng Xu, Zhourui jiang, Yihang Law, Wing-cheung Dong, Biqin Zeng, Xierong Ma, Mingze Xu, Gaixia Zou, Jizhao Yang, Chengbin J Nanobiotechnology Research Chemo-photothermal therapy based on nanoparticles has emerged as a promising strategy for cancer treatment. However, its therapeutic efficacy and application potential are largely subjected to the uncontrollability and biotoxicity of functional nanoplatforms. Herein, a novel biocompatible and biodegradable metal organic framework (MOF), which was constructed by growing crystalline zeolitic imidazolate framework-8 on gold nanoroad (Au@ZIF-8), was designed and fabricated for efficient drug loading and controlled release. Owing to the large surface area and guest-matching pore size of ZIF-8, doxorubicin (DOX) was successfully loaded into the Au@ZIF-8 with a high drug loading efficiency of ~ 37%. Under NIR light or weakly acidic environment, the ZIF-8 layer was quickly degraded, which resulted in an on-demand drug release in tumour site. More importantly, under the irradiation of near infrared (NIR) laser, highly efficient cancer treatment was achieved in both in vitro cell experiment and in vivo tumour-bearing nude mice experiment due to the synergistic effect of photothermal (PTT) therapy and chemotherapy. In addition, the in vivo study revealed the good biocompatibility of Au@ZIF-8. This work robustly suggested that Au@ZIF-8 could be further explored as a drug delivery system for chemo-photothermal synergistic therapy. [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-021-00961-x. BioMed Central 2021-07-19 /pmc/articles/PMC8287674/ /pubmed/34281545 http://dx.doi.org/10.1186/s12951-021-00961-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/ This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Huang, Junfeng
Xu, Zhourui
jiang, Yihang
Law, Wing-cheung
Dong, Biqin
Zeng, Xierong
Ma, Mingze
Xu, Gaixia
Zou, Jizhao
Yang, Chengbin
Metal organic framework-coated gold nanorod as an on-demand drug delivery platform for chemo-photothermal cancer therapy
title Metal organic framework-coated gold nanorod as an on-demand drug delivery platform for chemo-photothermal cancer therapy
title_full Metal organic framework-coated gold nanorod as an on-demand drug delivery platform for chemo-photothermal cancer therapy
title_fullStr Metal organic framework-coated gold nanorod as an on-demand drug delivery platform for chemo-photothermal cancer therapy
title_full_unstemmed Metal organic framework-coated gold nanorod as an on-demand drug delivery platform for chemo-photothermal cancer therapy
title_short Metal organic framework-coated gold nanorod as an on-demand drug delivery platform for chemo-photothermal cancer therapy
title_sort metal organic framework-coated gold nanorod as an on-demand drug delivery platform for chemo-photothermal cancer therapy
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287674/
https://www.ncbi.nlm.nih.gov/pubmed/34281545
http://dx.doi.org/10.1186/s12951-021-00961-x
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