Cargando…

TDP43 Exacerbates Atherosclerosis Progression by Promoting Inflammation and Lipid Uptake of Macrophages

OBJECTIVE: Atherosclerosis (AS), characterized by cholesterol overloaded-macrophages accumulation and plaque formation in blood vessels, is the major cause of cardiovascular disease. Transactive response DNA-binding protein∼43 kDa (TDP43) has recently been identified as an independent driver of neur...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huangfu, Ning, Wang, Yong, Xu, Zhenyu, Zheng, Wenyuan, Tao, Chunlan, Li, Zhenwei, Hu, Yewen, Chen, Xiaomin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287832/ https://www.ncbi.nlm.nih.gov/pubmed/34291051 http://dx.doi.org/10.3389/fcell.2021.687169

Ejemplares similares

Functional implication of ubiquitinating and deubiquitinating mechanisms in TDP-43 proteinopathies
por: Tran, Non-Nuoc, et al.
Publicado: (2022)

The Role of HDAC6 in TDP-43-Induced Neurotoxicity and UPS Impairment
por: Lee, Shinrye, et al.
Publicado: (2020)

Sequence Determinants of TDP-43 Ribonucleoprotein Condensate Formation and Axonal Transport in Neurons
por: Vishal, Sonali S., et al.
Publicado: (2022)

RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy
por: Necarsulmer, Julie C, et al.
Publicado: (2023)

TDP-43 Mutation Affects Stress Granule Dynamics in Differentiated NSC-34 Motoneuron-Like Cells
por: Ding, Qiao, et al.
Publicado: (2021)

DHX9 Strengthens Atherosclerosis Progression By Promoting Inflammation in Macrophages
por: Huangfu, Ning, et al.
Publicado: (2023)

Stage-specific control of oligodendrocyte survival and morphogenesis by TDP-43
por: Heo, Dongeun, et al.
Publicado: (2022)

Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1
por: Hipke, Katrin, et al.
Publicado: (2023)

Macrophage-Specific Connexin 43 Knockout Protects Mice from Obesity-Induced Inflammation and Metabolic Dysfunction
por: Choi, Cheoljun, et al.
Publicado: (2022)

Human Induced Pluripotent Stem Cell-Derived TDP-43 Mutant Neurons Exhibit Consistent Functional Phenotypes Across Multiple Gene Edited Lines Despite Transcriptomic and Splicing Discrepancies
por: Smith, Alec S. T., et al.
Publicado: (2021)

The Function, Regulation and Mechanism of Programmed Cell Death of Macrophages in Atherosclerosis
por: Liu, Chang, et al.
Publicado: (2022)

TDP-43 and Limbic-Predominant Age-Related TDP-43 Encephalopathy
por: Zhang, Lumi, et al.
Publicado: (2020)

DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation
por: Deshimaru, Manami, et al.
Publicado: (2021)

Mature iPSC-derived astrocytes of an ALS/FTD patient carrying the TDP43( A90V ) mutation display a mild reactive state and release polyP toxic to motoneurons
por: Rojas, Fabiola, et al.
Publicado: (2023)

Metformin protects against oxidized low density lipoprotein-induced macrophage apoptosis and inhibits lipid uptake
por: Huangfu, Ning, et al.
Publicado: (2018)

Blockade of Macrophage CD147 Protects Against Foam Cell Formation in Atherosclerosis
por: Lv, Jian-Jun, et al.
Publicado: (2021)

The Cellular Prion Protein Increases the Uptake and Toxicity of TDP-43 Fibrils
por: Scialò, Carlo, et al.
Publicado: (2021)

Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation
por: Gruijs da Silva, Lara A, et al.
Publicado: (2022)

Deficiency of LMP10 Attenuates Diet-Induced Atherosclerosis by Inhibiting Macrophage Polarization and Inflammation in Apolipoprotein E Deficient Mice
por: Liao, Jiawei, et al.
Publicado: (2020)

Neuronal Expression of UBQLN2(P497H) Exacerbates TDP-43 Pathology in TDP-43(G348C) Mice through Interaction with Ubiquitin
por: Picher-Martel, Vincent, et al.
Publicado: (2018)

Transient Lipid-Protein Structures and Selective Ganglioside Uptake During α-Synuclein-Lipid Co-aggregation
por: Gaspar, Ricardo, et al.
Publicado: (2021)

Rodent Models of TDP-43 Proteinopathy: Investigating the Mechanisms of TDP-43-Mediated Neurodegeneration
por: Gendron, Tania F., et al.
Publicado: (2011)

Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation
por: Ormeño, Fernando, et al.
Publicado: (2020)

YKL-40 Aggravates Early-Stage Atherosclerosis by Inhibiting Macrophage Apoptosis in an Aven-dependent Way
por: Huan, Wei, et al.
Publicado: (2021)

Neutrophil extracellular traps-mediated Beclin-1 suppression aggravates atherosclerosis by inhibiting macrophage autophagy
por: Sano, Masataka, et al.
Publicado: (2022)

YB1 protects cardiac myocytes against H(2)O(2)-induced injury via suppression of PIAS3 mRNA and phosphorylation of STAT3
por: Wang, Shiqi, et al.
Publicado: (2019)

Deciphering Macrophage Phenotypes upon Lipid Uptake and Atherosclerosis
por: Lee, Jihye, et al.
Publicado: (2020)

TDP-43 crosses the divide
por: Leslie, Mitch
Publicado: (2015)

Inflammation Induces TDP-43 Mislocalization and Aggregation
por: Correia, Ana Sofia, et al.
Publicado: (2015)

Body Complexion and Circulating Lipids in the Risk of TDP-43 Related Disorders
por: Esteban-García, Noelia, et al.
Publicado: (2022)

TDP-43: From Alzheimer’s Disease to Limbic-Predominant Age-Related TDP-43 Encephalopathy
por: Huang, Wendi, et al.
Publicado: (2020)

TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy
por: Atkinson, Rachel, et al.
Publicado: (2021)

The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation
por: Rengifo-Gonzalez, Juan Carlos, et al.
Publicado: (2021)

Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43
por: Keating, Sean S., et al.
Publicado: (2023)

Evidence of cerebellar TDP-43 loss of function in FTLD-TDP
por: Pickles, Sarah, et al.
Publicado: (2022)

Macrophage Paired Immunoglobulin-Like Receptor B Deficiency Promotes Peripheral Atherosclerosis in Apolipoprotein E–Deficient Mice
por: Su, Wenhua, et al.
Publicado: (2022)

TDP-43 regulates cancer-associated microRNAs
por: Chen, Xiaowei, et al.
Publicado: (2017)

TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells
por: Chang, Kae-Jiun, et al.
Publicado: (2021)

Antibody against TDP-43 phosphorylated at serine 375 suggests conformational differences of TDP-43 aggregates among FTLD–TDP subtypes
por: Neumann, Manuela, et al.
Publicado: (2020)

NLRP3-Mediated Inflammation in Atherosclerosis and Associated Therapeutics
por: Lu, Na, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fglg29r4u1pgh1e0udbj10qo2a