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Aberrant Autophagy Impacts Growth and Multicellular Development in a Dictyostelium Knockout Model of CLN5 Disease

Mutations in CLN5 cause a subtype of neuronal ceroid lipofuscinosis (NCL) called CLN5 disease. While the precise role of CLN5 in NCL pathogenesis is not known, recent work revealed that the protein has glycoside hydrolase activity. Previous work on the Dictyostelium discoideum homolog of human CLN5,...

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Detalles Bibliográficos
Autores principales:	McLaren, Meagan D., Mathavarajah, Sabateeshan, Kim, William D., Yap, Shyong Q., Huber, Robert J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287835/ https://www.ncbi.nlm.nih.gov/pubmed/34291044 http://dx.doi.org/10.3389/fcell.2021.657406

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