Cargando…

p53-intact cancers escape tumor suppression through loss of long noncoding RNA Dino

Many long noncoding RNA (lncRNA) genes exist near cancer-associated loci, yet evidence connecting lncRNA functions to recurrent genetic alterations in cancer are lacking. Here, we report that DINO, the lncRNA transcribed from the cancer-associated DINO/CDKN1A locus, suppresses tumor formation indepe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Marney, Christina B., Anderson, Erik S., Adnan, Mutayyaba, Peng, Kai-Lin, Hu, Ya, Weinhold, Nils, Schmitt, Adam M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287872/ https://www.ncbi.nlm.nih.gov/pubmed/34192538 http://dx.doi.org/10.1016/j.celrep.2021.109329

Ejemplares similares

A Unique Spectrum of Spontaneous Tumors in Dino Knockout Mice Identifies Tissue-Specific Requirements for Tumor Suppression
por: Marney, Christina B., et al.
Publicado: (2022)

Dino Pogolotti : un piemontese all'Avana = un piemontés en la Habana.
Publicado: (2004)

Dinos cómo sobrevivir a nuestra locura /
por: Ōe, Kenzaburō, 1935-
Publicado: (2000)

Expression of the Long Noncoding RNA DINO in Human Papillomavirus-Positive Cervical Cancer Cells Reactivates the Dormant TP53 Tumor Suppressor through ATM/CHK2 Signaling
por: Sharma, Surendra, et al.
Publicado: (2020)

Long non-coding RNA DINO promotes cisplatin sensitivity in lung adenocarcinoma via the p53-Bax axis
por: Liu, Zhile, et al.
Publicado: (2023)

Dinos and GoPros: Children’s exploratory behaviors in a museum and their reflections on their learning
por: Weisberg, Deena Skolnick, et al.
Publicado: (2023)

Isolation of the Bacteriophage DinoHI from Dichelobacter nodosus and its Interactions with other Integrated Genetic Elements
por: Cheetham, Brian F, et al.
Publicado: (2008)

Dino Buzzati’s 50(th) death anniversary: an appraisal of medicine and infectivology’s influence on his literary production
por: Lippi, Donatella, et al.
Publicado: (2022)

Health status in patients with COPD treated with roflumilast: two large noninterventional real-life studies: DINO and DACOTA
por: Kardos, Peter, et al.
Publicado: (2018)

Effect of vitamin D3 seasonal supplementation with 1500 IU/day in north Italian children (DINOS study)
por: Mazzoleni, Stefano, et al.
Publicado: (2019)

A Semi-supervised Learning Method for Q-Matrix Specification Under the DINA and DINO Model With Independent Structure
por: Wang, Wenyi, et al.
Publicado: (2020)

A prospective observational study of iron isomaltoside in haemodialysis patients with chronic kidney disease treated for iron deficiency (DINO)
por: Mikhail, Ashraf I., et al.
Publicado: (2019)

Noncoding RNAs: the shot callers in tumor immune escape
por: Liu, Lei, et al.
Publicado: (2020)

Parental Diabetes Behaviors and Distress Are Related to Glycemic Control in Youth with Type 1 Diabetes: Longitudinal Data from the DINO Study
por: Eilander, Minke M. A., et al.
Publicado: (2017)

Cancer cells escape p53’s tumor suppression through ablation of ZDHHC1-mediated p53 palmitoylation
por: Tang, Jun, et al.
Publicado: (2021)

PRMT5-dependent p53 escape in tumorigenesis
por: Li, Yan, et al.
Publicado: (2015)

Diabetes IN develOpment (DINO): the bio-psychosocial, family functioning and parental well-being of youth with type 1 diabetes: a longitudinal cohort study design
por: Eilander, Minke M. A., et al.
Publicado: (2015)

Is there an interest in repeating the vaginal administration of dinoprostone (Propess®), to promote induction of labor of pregnant women at term? (RE-DINO): study protocol for a randomized controlled trial
por: Coste Mazeau, P., et al.
Publicado: (2020)

TP53-inducible putative long noncoding RNAs encode functional polypeptides that suppress cell proliferation
por: Xu, Wenli, et al.
Publicado: (2022)

Intact p53-Dependent Responses in miR-34–Deficient Mice
por: Concepcion, Carla P., et al.
Publicado: (2012)

CRISPR-Cas influences the acquisition of antibiotic resistance in Klebsiella pneumoniae
por: Mackow, Natalie A., et al.
Publicado: (2019)

Loss of fragile WWOX gene leads to senescence escape and genome instability
por: Cheng, Hui-Ching, et al.
Publicado: (2023)

Antigen Loss Variants: Catching Hold of Escaping Foes
por: Vyas, Maulik, et al.
Publicado: (2017)

Facial lesions in piglets with intact or grinded teeth
por: Hansson, Monica, et al.
Publicado: (2012)

Repetition Suppression for Noisy and Intact Faces in the Occipito-Temporal Cortex
por: Rostalski, Sophie-Marie, et al.
Publicado: (2019)

Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity
por: Isermann, Tamara, et al.
Publicado: (2021)

Wastewater treatment plants, an “escape gate” for ESCAPE pathogens
por: Marutescu, Luminita Gabriela, et al.
Publicado: (2023)

Inactivation of the tumor suppressor p53 by long noncoding RNA RMRP
por: Chen, Yajie, et al.
Publicado: (2021)

Correlation of the tumor escape phenotype with loss of PRELP expression in melanoma
por: Schäfer, Helene, et al.
Publicado: (2023)

The Elephant Evolved p53 Isoforms that Escape MDM2-Mediated Repression and Cancer
por: Padariya, Monikaben, et al.
Publicado: (2022)

Dinoflagellate symbionts escape vomocytosis by host cell immune suppression
por: Jacobovitz, Marie R., et al.
Publicado: (2021)

Retrotransposition-Competent Human LINE-1 Induces Apoptosis in Cancer Cells With Intact p53
por: Haoudi, Abdelali, et al.
Publicado: (2004)

Molecular Characterization of an Intact p53 Pathway Subtype in High-Grade Serous Ovarian Cancer
por: Hayano, Takahide, et al.
Publicado: (2014)

Intact HIV Proviruses Persist in the Brain Despite Viral Suppression with ART
por: Cochrane, Catherine R., et al.
Publicado: (2022)

Combined Dusp4 and p53 loss with Dbf4 amplification drives tumorigenesis via cell cycle restriction and replication stress escape in breast cancer
por: Hanna, Ann, et al.
Publicado: (2022)

Mutant p53 gain of function mediates cancer immune escape that is counteracted by APR-246
por: Zhou, Xiaolei, et al.
Publicado: (2022)

Central role of the p53 pathway in the noncoding-RNA response to oxidative stress
por: Fuschi, Paola, et al.
Publicado: (2017)

Long noncoding RNAs: p53’s secret weapon in the fight against cancer?
por: Dangelmaier, Emily, et al.
Publicado: (2019)

Reciprocal modulation of long noncoding RNA EMS and p53 regulates tumorigenesis
por: Wang, Chenfeng, et al.
Publicado: (2022)

Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution
por: McGranahan, Nicholas, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ob0ra7o92gkeqmk20j9aj8u1tm