Locus-specific transcription silencing at the FHIT gene suppresses replication stress-induced copy number variant formation and associated replication delay

Impaired replication progression leads to de novo copy number variant (CNV) formation at common fragile sites (CFSs). We previously showed that these hotspots for genome instability reside in late-replicating domains associated with large transcribed genes and provided indirect evidence that transcr...

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Detalles Bibliográficos
Autores principales: Park, So Hae, Bennett-Baker, Pamela, Ahmed, Samreen, Arlt, Martin F, Ljungman, Mats, Glover, Thomas W, Wilson, Thomas E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287918/
https://www.ncbi.nlm.nih.gov/pubmed/34181717
http://dx.doi.org/10.1093/nar/gkab559

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