Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase

N6-methyladenosine (m6A) is a common modification on endogenous RNA transcripts in mammalian cells. Technologies to precisely modify the RNA m6A levels at specific transcriptomic loci empower interrogation of biological functions of epitranscriptomic modifications. Here, we developed a bidirectional...

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Detalles Bibliográficos
Autores principales: Xia, Zhen, Tang, Min, Ma, Jiayan, Zhang, Hongyan, Gimple, Ryan C, Prager, Briana C, Tang, Hongzhen, Sun, Chongran, Liu, Fuyi, Lin, Peng, Mei, Yutang, Du, Ruoxin, Rich, Jeremy N, Xie, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287920/
https://www.ncbi.nlm.nih.gov/pubmed/34181729
http://dx.doi.org/10.1093/nar/gkab517

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