Replication catastrophe induced by cyclic hypoxia leads to increased APOBEC3B activity

Tumor heterogeneity includes variable and fluctuating oxygen concentrations, which result in the accumulation of hypoxic regions in most solid tumors. Tumor hypoxia leads to increased therapy resistance and has been linked to genomic instability. Here, we tested the hypothesis that exposure to level...

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Detalles Bibliográficos
Autores principales: Bader, Samuel B, Ma, Tiffany S, Simpson, Charlotte J, Liang, Jiachen, Maezono, Sakura Eri B, Olcina, Monica M, Buffa, Francesca M, Hammond, Ester M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287932/
https://www.ncbi.nlm.nih.gov/pubmed/34197599
http://dx.doi.org/10.1093/nar/gkab551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287932/
https://www.ncbi.nlm.nih.gov/pubmed/34197599
http://dx.doi.org/10.1093/nar/gkab551

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