Strand-specific effect of Rad26 and TFIIS in rescuing transcriptional arrest by CAG trinucleotide repeat slip-outs

Transcription induced CAG repeat instability is associated with fatal neurological disorders. Genetic approaches found transcription-coupled nucleotide excision repair (TC-NER) factor CSB protein and TFIIS play critical roles in modulating the repeat stability. Here, we took advantage of an in vitro...

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Detalles Bibliográficos
Autores principales: Xu, Jun, Chong, Jenny, Wang, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287942/
https://www.ncbi.nlm.nih.gov/pubmed/34197619
http://dx.doi.org/10.1093/nar/gkab573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287942/
https://www.ncbi.nlm.nih.gov/pubmed/34197619
http://dx.doi.org/10.1093/nar/gkab573

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