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Impact of the interplay between stemness features, p53 and pol iota on replication pathway choices

Using human embryonic, adult and cancer stem cells/stem cell-like cells (SCs), we demonstrate that DNA replication speed differs in SCs and their differentiated counterparts. While SCs decelerate DNA replication, differentiated cells synthesize DNA faster and accumulate DNA damage. Notably, both rep...

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Detalles Bibliográficos
Autores principales:	Ihle, Michaela, Biber, Stephanie, Schroeder, Insa S, Blattner, Christine, Deniz, Miriam, Damia, Giovanna, Gottifredi, Vanesa, Wiesmüller, Lisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287946/ https://www.ncbi.nlm.nih.gov/pubmed/34165573 http://dx.doi.org/10.1093/nar/gkab526

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