Cargando…

Usefulness of FT3 to FT4 Ratio to Predict Mortality in Euthyroid Patients With Prior Cardiovascular Events Undergoing PCI: Five-Year Findings From a Large Single-Center Cohort Study

BACKGROUND: In euthyroid patients undergoing percutaneous coronary intervention (PCI), it is still unclear whether free triiodothyronine to free thyroxine (FT3/FT4) ratio can predict the recurrence of cardiovascular events (CVEs). We aim to investigate its association with recurrent long-term advers...

Descripción completa

Detalles Bibliográficos
Autores principales: Yuan, Deshan, Jia, Sida, Zhu, Pei, Zhang, Ce, Liu, Yue, Liu, Ru, Xu, Jingjing, Tang, Xiaofang, Zhao, Xueyan, Gao, Runlin, Yang, Yuejin, Xu, Bo, Gao, Zhan, Yuan, Jinqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287966/
https://www.ncbi.nlm.nih.gov/pubmed/34290672
http://dx.doi.org/10.3389/fendo.2021.700349
_version_ 1783724011034771456
author Yuan, Deshan
Jia, Sida
Zhu, Pei
Zhang, Ce
Liu, Yue
Liu, Ru
Xu, Jingjing
Tang, Xiaofang
Zhao, Xueyan
Gao, Runlin
Yang, Yuejin
Xu, Bo
Gao, Zhan
Yuan, Jinqing
author_facet Yuan, Deshan
Jia, Sida
Zhu, Pei
Zhang, Ce
Liu, Yue
Liu, Ru
Xu, Jingjing
Tang, Xiaofang
Zhao, Xueyan
Gao, Runlin
Yang, Yuejin
Xu, Bo
Gao, Zhan
Yuan, Jinqing
author_sort Yuan, Deshan
collection PubMed
description BACKGROUND: In euthyroid patients undergoing percutaneous coronary intervention (PCI), it is still unclear whether free triiodothyronine to free thyroxine (FT3/FT4) ratio can predict the recurrence of cardiovascular events (CVEs). We aim to investigate its association with recurrent long-term adverse events in this population. METHODS: 3549 euthyroid patients with prior CVEs history undergoing PCI were consecutively enrolled in our study and subsequently divided into three FT3/FT4 ratio tertiles (T1<2.41, n=1170; 2.41≤T2<2.75, n=1198; T3>2.75, n=1181). The primary endpoint was major adverse cardiovascular and cerebrovascular event (MACCE), a composite of all-cause death, myocardial infarction, stroke and revascularization. The secondary endpoints were all-cause death and cardiac death. RESULTS: The median follow-up time was 5 years. The incidence of all-cause death, cardiac death and MACCE were significantly higher among patients in the lowest FT3/FT4 tertile (P<0.05). After adjustment of confounding factors, decreased FT3/FT4 ratio was independently associated with an increased risk of all-cause death (HR 1.82, 95% CI 1.13-2.93, P=0.014), cardiac death (HR 1.90, 95% CI 1.04-3.46, P=0.036) and MACCE (HR 1.33, 95% CI 1.10-1.60, P=0.003) which was driven mainly by all-cause death. CONCLUSIONS: In euthyroid patients with prior cardiovascular events undergoing PCI, FT3/FT4 ratio might be a potential predictor of all-cause and cardiac mortality. Routine assessment of FT3/FT4 ratio might be a simple and effective tool for risk stratification in this specific patient population.
format Online
Article
Text
id pubmed-8287966
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-82879662021-07-20 Usefulness of FT3 to FT4 Ratio to Predict Mortality in Euthyroid Patients With Prior Cardiovascular Events Undergoing PCI: Five-Year Findings From a Large Single-Center Cohort Study Yuan, Deshan Jia, Sida Zhu, Pei Zhang, Ce Liu, Yue Liu, Ru Xu, Jingjing Tang, Xiaofang Zhao, Xueyan Gao, Runlin Yang, Yuejin Xu, Bo Gao, Zhan Yuan, Jinqing Front Endocrinol (Lausanne) Endocrinology BACKGROUND: In euthyroid patients undergoing percutaneous coronary intervention (PCI), it is still unclear whether free triiodothyronine to free thyroxine (FT3/FT4) ratio can predict the recurrence of cardiovascular events (CVEs). We aim to investigate its association with recurrent long-term adverse events in this population. METHODS: 3549 euthyroid patients with prior CVEs history undergoing PCI were consecutively enrolled in our study and subsequently divided into three FT3/FT4 ratio tertiles (T1<2.41, n=1170; 2.41≤T2<2.75, n=1198; T3>2.75, n=1181). The primary endpoint was major adverse cardiovascular and cerebrovascular event (MACCE), a composite of all-cause death, myocardial infarction, stroke and revascularization. The secondary endpoints were all-cause death and cardiac death. RESULTS: The median follow-up time was 5 years. The incidence of all-cause death, cardiac death and MACCE were significantly higher among patients in the lowest FT3/FT4 tertile (P<0.05). After adjustment of confounding factors, decreased FT3/FT4 ratio was independently associated with an increased risk of all-cause death (HR 1.82, 95% CI 1.13-2.93, P=0.014), cardiac death (HR 1.90, 95% CI 1.04-3.46, P=0.036) and MACCE (HR 1.33, 95% CI 1.10-1.60, P=0.003) which was driven mainly by all-cause death. CONCLUSIONS: In euthyroid patients with prior cardiovascular events undergoing PCI, FT3/FT4 ratio might be a potential predictor of all-cause and cardiac mortality. Routine assessment of FT3/FT4 ratio might be a simple and effective tool for risk stratification in this specific patient population. Frontiers Media S.A. 2021-07-05 /pmc/articles/PMC8287966/ /pubmed/34290672 http://dx.doi.org/10.3389/fendo.2021.700349 Text en Copyright © 2021 Yuan, Jia, Zhu, Zhang, Liu, Liu, Xu, Tang, Zhao, Gao, Yang, Xu, Gao and Yuan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Yuan, Deshan
Jia, Sida
Zhu, Pei
Zhang, Ce
Liu, Yue
Liu, Ru
Xu, Jingjing
Tang, Xiaofang
Zhao, Xueyan
Gao, Runlin
Yang, Yuejin
Xu, Bo
Gao, Zhan
Yuan, Jinqing
Usefulness of FT3 to FT4 Ratio to Predict Mortality in Euthyroid Patients With Prior Cardiovascular Events Undergoing PCI: Five-Year Findings From a Large Single-Center Cohort Study
title Usefulness of FT3 to FT4 Ratio to Predict Mortality in Euthyroid Patients With Prior Cardiovascular Events Undergoing PCI: Five-Year Findings From a Large Single-Center Cohort Study
title_full Usefulness of FT3 to FT4 Ratio to Predict Mortality in Euthyroid Patients With Prior Cardiovascular Events Undergoing PCI: Five-Year Findings From a Large Single-Center Cohort Study
title_fullStr Usefulness of FT3 to FT4 Ratio to Predict Mortality in Euthyroid Patients With Prior Cardiovascular Events Undergoing PCI: Five-Year Findings From a Large Single-Center Cohort Study
title_full_unstemmed Usefulness of FT3 to FT4 Ratio to Predict Mortality in Euthyroid Patients With Prior Cardiovascular Events Undergoing PCI: Five-Year Findings From a Large Single-Center Cohort Study
title_short Usefulness of FT3 to FT4 Ratio to Predict Mortality in Euthyroid Patients With Prior Cardiovascular Events Undergoing PCI: Five-Year Findings From a Large Single-Center Cohort Study
title_sort usefulness of ft3 to ft4 ratio to predict mortality in euthyroid patients with prior cardiovascular events undergoing pci: five-year findings from a large single-center cohort study
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287966/
https://www.ncbi.nlm.nih.gov/pubmed/34290672
http://dx.doi.org/10.3389/fendo.2021.700349
work_keys_str_mv AT yuandeshan usefulnessofft3toft4ratiotopredictmortalityineuthyroidpatientswithpriorcardiovasculareventsundergoingpcifiveyearfindingsfromalargesinglecentercohortstudy
AT jiasida usefulnessofft3toft4ratiotopredictmortalityineuthyroidpatientswithpriorcardiovasculareventsundergoingpcifiveyearfindingsfromalargesinglecentercohortstudy
AT zhupei usefulnessofft3toft4ratiotopredictmortalityineuthyroidpatientswithpriorcardiovasculareventsundergoingpcifiveyearfindingsfromalargesinglecentercohortstudy
AT zhangce usefulnessofft3toft4ratiotopredictmortalityineuthyroidpatientswithpriorcardiovasculareventsundergoingpcifiveyearfindingsfromalargesinglecentercohortstudy
AT liuyue usefulnessofft3toft4ratiotopredictmortalityineuthyroidpatientswithpriorcardiovasculareventsundergoingpcifiveyearfindingsfromalargesinglecentercohortstudy
AT liuru usefulnessofft3toft4ratiotopredictmortalityineuthyroidpatientswithpriorcardiovasculareventsundergoingpcifiveyearfindingsfromalargesinglecentercohortstudy
AT xujingjing usefulnessofft3toft4ratiotopredictmortalityineuthyroidpatientswithpriorcardiovasculareventsundergoingpcifiveyearfindingsfromalargesinglecentercohortstudy
AT tangxiaofang usefulnessofft3toft4ratiotopredictmortalityineuthyroidpatientswithpriorcardiovasculareventsundergoingpcifiveyearfindingsfromalargesinglecentercohortstudy
AT zhaoxueyan usefulnessofft3toft4ratiotopredictmortalityineuthyroidpatientswithpriorcardiovasculareventsundergoingpcifiveyearfindingsfromalargesinglecentercohortstudy
AT gaorunlin usefulnessofft3toft4ratiotopredictmortalityineuthyroidpatientswithpriorcardiovasculareventsundergoingpcifiveyearfindingsfromalargesinglecentercohortstudy
AT yangyuejin usefulnessofft3toft4ratiotopredictmortalityineuthyroidpatientswithpriorcardiovasculareventsundergoingpcifiveyearfindingsfromalargesinglecentercohortstudy
AT xubo usefulnessofft3toft4ratiotopredictmortalityineuthyroidpatientswithpriorcardiovasculareventsundergoingpcifiveyearfindingsfromalargesinglecentercohortstudy
AT gaozhan usefulnessofft3toft4ratiotopredictmortalityineuthyroidpatientswithpriorcardiovasculareventsundergoingpcifiveyearfindingsfromalargesinglecentercohortstudy
AT yuanjinqing usefulnessofft3toft4ratiotopredictmortalityineuthyroidpatientswithpriorcardiovasculareventsundergoingpcifiveyearfindingsfromalargesinglecentercohortstudy