Host Gasdermin D restrains systemic endotoxemia by capturing Proteobacteria in the colon of high-fat diet-feeding mice

Gasdermin D (GSDMD) functions as a key pyroptotic executor through its secreted N-terminal domain (GSDMD-N). However, the functional relevance and mechanistic basis of the precise roles of host colonic GSDMD in high-fat diet (HFD)-induced gut dysbiosis and systemic endotoxemia remain elusive. In thi...

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Detalles Bibliográficos
Autores principales: Shi, Yujie, Zou, Yixin, Xiong, Yonghong, Zhang, Shiyao, Song, Mingming, An, Xiaofei, Liu, Chang, Zhang, Wenxiang, Chen, Siyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288038/
https://www.ncbi.nlm.nih.gov/pubmed/34275417
http://dx.doi.org/10.1080/19490976.2021.1946369

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