Cargando…

Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor

Elevated serum concentrations of leucine-rich α-2-glycoprotein (LRG1) have been reported in patients with inflammatory, autoimmune, and cardiovascular diseases. This study aims to investigate the role of LRG1 in endothelial activation. LRG1 in endothelial cells (ECs) of arteries and serum of patient...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pang, Kuin Tian, Ghim, Mean, Liu, Chenghao, Tay, Hui Min, Fhu, Chee Wai, Chia, Rui Ning, Qiu, Beiying, Sarathchandra, Padmini, Chester, Adrian H., Yacoub, Magdi H., Wilkinson, Fiona L., Weston, Ria, Warboys, Christina M., Hou, Han Wei, Weinberg, Peter D., Wang, Xiaomeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288075/ https://www.ncbi.nlm.nih.gov/pubmed/34291056 http://dx.doi.org/10.3389/fcell.2021.706143

Ejemplares similares

A novel method for segmenting growth of cells in sheared endothelial culture reveals the secretion of an anti-inflammatory mediator
por: Ghim, Mean, et al.
Publicado: (2018)

Understanding mechanobiology in cultured endothelium: A review of the orbital shaker method
por: Warboys, Christina M., et al.
Publicado: (2019)

Organ Culture Model of Aortic Valve Calcification
por: Chester, Adrian H., et al.
Publicado: (2021)

Cardiac regeneration following cryoinjury in the adult zebrafish targets a maturation-specific biomechanical remodeling program
por: Yu, Joseph K., et al.
Publicado: (2018)

Atypical Expression of Smooth Muscle Markers and Co-activators and Their Regulation in Rheumatic Aortic and Calcified Bicuspid Valves
por: Latif, Najma, et al.
Publicado: (2022)

Modulation of Human Valve Interstitial Cell Phenotype and Function Using a Fibroblast Growth Factor 2 Formulation
por: Latif, Najma, et al.
Publicado: (2015)

Severe degeneration of a sub-coronary pulmonary autograft in a young adult
por: Latif, Najma, et al.
Publicado: (2021)

NO Synthesis but Not Apoptosis, Mitosis or Inflammation Can Explain Correlations between Flow Directionality and Paracellular Permeability of Cultured Endothelium
por: Ghim, Mean, et al.
Publicado: (2022)

Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP
por: Sammel, Martin, et al.
Publicado: (2019)

Role of hypoxia inducible factor HIF-1α in heart valves
por: Georgy, Mark, et al.
Publicado: (2023)

Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway
por: Rickman, Matthew, et al.
Publicado: (2023)

Endothelial cells exposed to atheroprotective flow secrete follistatin-like 1 protein which reduces transcytosis and inflammation
por: Ghim, Mean, et al.
Publicado: (2021)

A Multifunctional Role of Leucine-Rich α-2-Glycoprotein 1 in Cutaneous Wound Healing Under Normal and Diabetic Conditions
por: Liu, Chenghao, et al.
Publicado: (2020)

Expression and function of mechanosensitive ion channels in human valve interstitial cells
por: Al-Shammari, Hessah, et al.
Publicado: (2020)

LRP1 shedding in human brain: roles of ADAM10 and ADAM17
por: Liu, Qiang, et al.
Publicado: (2009)

PKCα and PKCδ Regulate ADAM17-Mediated Ectodomain Shedding of Heparin Binding-EGF through Separate Pathways
por: Kveiborg, Marie, et al.
Publicado: (2011)

The Role of Tricellular Junctions in the Transport of Macromolecules Across Endothelium
por: Ghim, Mean, et al.
Publicado: (2020)

Characterization of Porcine Aortic Valvular Interstitial Cell ‘Calcified’ Nodules
por: Cloyd, Kristy L., et al.
Publicado: (2012)

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands
por: Sahin, Umut, et al.
Publicado: (2004)

Biocompatibility and Application of Carbon Fibers in Heart Valve Tissue Engineering
por: Tseng, Yuan-Tsan, et al.
Publicado: (2021)

The ADAM15 ectodomain is shed from secretory exosomes
por: Lee, Hee Doo, et al.
Publicado: (2015)

Regulation of ectodomain shedding of ADAM33 in vitro and in vivo
por: Davies, Elizabeth R., et al.
Publicado: (2019)

ADAM17-Mediated Shedding of Inflammatory Cytokines in Hypertension
por: de Queiroz, Thyago M., et al.
Publicado: (2020)

ADAM10 mediates shedding of carbonic anhydrase IX ectodomain non-redundantly to ADAM17
por: Zatovicova, Miriam, et al.
Publicado: (2022)

Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signalling via enhanced ectodomain shedding of TNF-α
por: Kanda, Keitaro, et al.
Publicado: (2012)

Extracellular sphingomyelinase activity impairs TNF-α-induced endothelial cell death via ADAM17 activation and TNF receptor 1 shedding
por: Sommer, Anselm, et al.
Publicado: (2017)

Role of ADAMs in the Ectodomain Shedding and Conformational Conversion of the Prion Protein
por: Taylor, David R., et al.
Publicado: (2009)

Cytoplasmic Relaxation of Active Eph Controls Ephrin Shedding by ADAM10
por: Janes, Peter W., et al.
Publicado: (2009)

Cell surface annexins regulate ADAM-mediated ectodomain shedding of proamphiregulin
por: Nakayama, Hironao, et al.
Publicado: (2012)

ADAM17 is essential for ectodomain shedding of the EGF‐receptor ligand amphiregulin
por: Hosur, Vishnu, et al.
Publicado: (2018)

Involvement of shedding induced by ADAM17 on the nitric oxide pathway in hypertension
por: da Silva, Mirelly Cunha, et al.
Publicado: (2022)

The role of endothelin-1 in pulmonary arterial hypertension
por: Chester, Adrian H., et al.
Publicado: (2014)

Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein
por: Linsenmeier, Luise, et al.
Publicado: (2018)

NKG2D Ligand Shedding in Response to Stress: Role of ADAM10
por: Zingoni, Alessandra, et al.
Publicado: (2020)

Transamination-Like Reaction Catalyzed by Leucine Dehydrogenase for Efficient Co-Synthesis of α-Amino Acids and α-Keto Acids
por: Mu, Xiaoqing, et al.
Publicado: (2021)

The collectrin‐like part of the SARS‐CoV‐1 and ‐2 receptor ACE2 is shed by the metalloproteinases ADAM10 and ADAM17
por: Niehues, Rabea Victoria, et al.
Publicado: (2022)

Caspr1 Facilitates sAPPα Production by Regulating α-Secretase ADAM9 in Brain Endothelial Cells
por: Tang, Shi-Yu, et al.
Publicado: (2020)

Synapse Maturation by Activity-Dependent Ectodomain Shedding of SIRPα
por: Toth, Anna B., et al.
Publicado: (2013)

Nitric oxide and pulmonary arterial hypertension
por: Chester, Adrian H., et al.
Publicado: (2017)

Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia
por: Díaz, Begoña, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_6dlgh3j6qeiqe2rallohm8kuev