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Variability of blood eosinophil count and prognosis of COPD exacerbations

BACKGROUND: Eosinophils in peripheral blood are one of the emerging biomarkers in chronic obstructive pulmonary disease (COPD) patients. However, when analysing the relationship between peripheral eosinophilia and COPD prognosis, highly variable results are obtained. The aim of our study is to descr...

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Autores principales: Martínez-Gestoso, Sandra, García-Sanz, María-Teresa, Calvo-Álvarez, Uxío, Doval-Oubiña, Liliana, Camba-Matos, Sandra, Salgado, Francisco-Javier, Muñoz, Xavier, Perez-Lopez-Corona, Purificación, González-Barcala, Francisco-Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288128/
https://www.ncbi.nlm.nih.gov/pubmed/34269633
http://dx.doi.org/10.1080/07853890.2021.1949489
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author Martínez-Gestoso, Sandra
García-Sanz, María-Teresa
Calvo-Álvarez, Uxío
Doval-Oubiña, Liliana
Camba-Matos, Sandra
Salgado, Francisco-Javier
Muñoz, Xavier
Perez-Lopez-Corona, Purificación
González-Barcala, Francisco-Javier
author_facet Martínez-Gestoso, Sandra
García-Sanz, María-Teresa
Calvo-Álvarez, Uxío
Doval-Oubiña, Liliana
Camba-Matos, Sandra
Salgado, Francisco-Javier
Muñoz, Xavier
Perez-Lopez-Corona, Purificación
González-Barcala, Francisco-Javier
author_sort Martínez-Gestoso, Sandra
collection PubMed
description BACKGROUND: Eosinophils in peripheral blood are one of the emerging biomarkers in chronic obstructive pulmonary disease (COPD) patients. However, when analysing the relationship between peripheral eosinophilia and COPD prognosis, highly variable results are obtained. The aim of our study is to describe the serum eosinophilia levels in COPD patients and to analyse their relationship to prognosis following hospital admission. METHODS: A prospective observational study was conducted from 1 October 2016 to 1 October 2018 in the following Spanish centres: Salnés County Hospital in Vilagarcía de Arousa, Arquitecto Marcide Hospital in Ferrol and the University Hospital Complex in Santiago de Compostela. The patients were classified using three cut-off points of blood eosinophil count (BEC): 150 cells/µL, 300 cells/µL, and 400 cells/µL; in addition, the peripheral BEC was analysed on admission. RESULTS: 615 patients were included in the study, 86.2% male, mean age 73.9 years, and mean FEV1 52.7%. The mean stay was 8.4 days, and 6% of all patients were readmitted early. No significant relationship was observed between the BEC, neither in the stable phase nor in the acute phase, and hospital stay, readmissions, deaths during admission, the need for intensive care, or the condition of frequent exacerbator. CONCLUSION: The results of our study do not seem to support the usefulness of BEC as a COPD biomarker. KEY MESSAGES: 1. There is evidence that BEC participates in pathophysiological mechanisms of the COPD. 2. BEC may be useful as a biomarker in COPD for aspects such as the optimization of treatments. 3. We did not find any relationship between BEC levels and prognosis following hospital admission for AECOPD.
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spelling pubmed-82881282021-08-02 Variability of blood eosinophil count and prognosis of COPD exacerbations Martínez-Gestoso, Sandra García-Sanz, María-Teresa Calvo-Álvarez, Uxío Doval-Oubiña, Liliana Camba-Matos, Sandra Salgado, Francisco-Javier Muñoz, Xavier Perez-Lopez-Corona, Purificación González-Barcala, Francisco-Javier Ann Med Pulmonary Medicine BACKGROUND: Eosinophils in peripheral blood are one of the emerging biomarkers in chronic obstructive pulmonary disease (COPD) patients. However, when analysing the relationship between peripheral eosinophilia and COPD prognosis, highly variable results are obtained. The aim of our study is to describe the serum eosinophilia levels in COPD patients and to analyse their relationship to prognosis following hospital admission. METHODS: A prospective observational study was conducted from 1 October 2016 to 1 October 2018 in the following Spanish centres: Salnés County Hospital in Vilagarcía de Arousa, Arquitecto Marcide Hospital in Ferrol and the University Hospital Complex in Santiago de Compostela. The patients were classified using three cut-off points of blood eosinophil count (BEC): 150 cells/µL, 300 cells/µL, and 400 cells/µL; in addition, the peripheral BEC was analysed on admission. RESULTS: 615 patients were included in the study, 86.2% male, mean age 73.9 years, and mean FEV1 52.7%. The mean stay was 8.4 days, and 6% of all patients were readmitted early. No significant relationship was observed between the BEC, neither in the stable phase nor in the acute phase, and hospital stay, readmissions, deaths during admission, the need for intensive care, or the condition of frequent exacerbator. CONCLUSION: The results of our study do not seem to support the usefulness of BEC as a COPD biomarker. KEY MESSAGES: 1. There is evidence that BEC participates in pathophysiological mechanisms of the COPD. 2. BEC may be useful as a biomarker in COPD for aspects such as the optimization of treatments. 3. We did not find any relationship between BEC levels and prognosis following hospital admission for AECOPD. Taylor & Francis 2021-07-16 /pmc/articles/PMC8288128/ /pubmed/34269633 http://dx.doi.org/10.1080/07853890.2021.1949489 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Pulmonary Medicine
Martínez-Gestoso, Sandra
García-Sanz, María-Teresa
Calvo-Álvarez, Uxío
Doval-Oubiña, Liliana
Camba-Matos, Sandra
Salgado, Francisco-Javier
Muñoz, Xavier
Perez-Lopez-Corona, Purificación
González-Barcala, Francisco-Javier
Variability of blood eosinophil count and prognosis of COPD exacerbations
title Variability of blood eosinophil count and prognosis of COPD exacerbations
title_full Variability of blood eosinophil count and prognosis of COPD exacerbations
title_fullStr Variability of blood eosinophil count and prognosis of COPD exacerbations
title_full_unstemmed Variability of blood eosinophil count and prognosis of COPD exacerbations
title_short Variability of blood eosinophil count and prognosis of COPD exacerbations
title_sort variability of blood eosinophil count and prognosis of copd exacerbations
topic Pulmonary Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288128/
https://www.ncbi.nlm.nih.gov/pubmed/34269633
http://dx.doi.org/10.1080/07853890.2021.1949489
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