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Red blood cell membrane-camouflaged nanoparticles loaded with AIEgen and Poly(I : C) for enhanced tumoral photodynamic-immunotherapy

Red blood cell (RBC)-mimicking nanoparticles (NPs) offer a promising platform for drug delivery because of their prolonged circulation time, reduced immunogenicity and specific targeting ability. Herein, we report the design and preparation of RBC membrane-bound NPs (M@AP), for tumoral photodynamic-...

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Autores principales: Dai, Jun, Wu, Meng, Wang, Quan, Ding, Siyang, Dong, Xiaoqi, Xue, Liru, Zhu, Qingqing, Zhou, Jian, Xia, Fan, Wang, Shixuan, Hong, Yuning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288176/
https://www.ncbi.nlm.nih.gov/pubmed/34691671
http://dx.doi.org/10.1093/nsr/nwab039
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author Dai, Jun
Wu, Meng
Wang, Quan
Ding, Siyang
Dong, Xiaoqi
Xue, Liru
Zhu, Qingqing
Zhou, Jian
Xia, Fan
Wang, Shixuan
Hong, Yuning
author_facet Dai, Jun
Wu, Meng
Wang, Quan
Ding, Siyang
Dong, Xiaoqi
Xue, Liru
Zhu, Qingqing
Zhou, Jian
Xia, Fan
Wang, Shixuan
Hong, Yuning
author_sort Dai, Jun
collection PubMed
description Red blood cell (RBC)-mimicking nanoparticles (NPs) offer a promising platform for drug delivery because of their prolonged circulation time, reduced immunogenicity and specific targeting ability. Herein, we report the design and preparation of RBC membrane-bound NPs (M@AP), for tumoral photodynamic-immunotherapy. The M@AP is formed by self-assembly of the positively charged aggregation-induced emission luminogen (AIEgen) (named P2-PPh3) and the negatively charged polyinosinic : polycytidylic acid (Poly(I : C)), followed by RBC membrane encapsulation. P2-PPh3 is an AIE-active conjugated polyelectrolyte with additional photosensitizing ability for photodynamic therapy (PDT), while Poly(I : C) serves as an immune-stimulant to stimulate both tumor and immune cells to activate immunity, and thus reduces tumor cell viability. When applied in tumor-bearing mice, the M@AP NPs are enriched in both the tumor region as a result of an enhanced permeability and retention (EPR) effect, and the spleen because of the homing effect of the RBC-mimicking shell. Upon light irradiation, P2-PPh3 promotes strong ROS generation in tumor cells, inducing the release of tumor antigens (TA). The anti-tumor immunity is further enhanced by the presence of Poly(I : C) in M@AP. Thus, this strategy combines the PDT properties of the AIE-active polyelectrolyte and immunotherapy properties of Poly(I : C) to achieve synergistic activation of the immune system for anti-tumor activity, providing a novel strategy for tumor treatment.
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spelling pubmed-82881762021-10-21 Red blood cell membrane-camouflaged nanoparticles loaded with AIEgen and Poly(I : C) for enhanced tumoral photodynamic-immunotherapy Dai, Jun Wu, Meng Wang, Quan Ding, Siyang Dong, Xiaoqi Xue, Liru Zhu, Qingqing Zhou, Jian Xia, Fan Wang, Shixuan Hong, Yuning Natl Sci Rev CHEMISTRY Red blood cell (RBC)-mimicking nanoparticles (NPs) offer a promising platform for drug delivery because of their prolonged circulation time, reduced immunogenicity and specific targeting ability. Herein, we report the design and preparation of RBC membrane-bound NPs (M@AP), for tumoral photodynamic-immunotherapy. The M@AP is formed by self-assembly of the positively charged aggregation-induced emission luminogen (AIEgen) (named P2-PPh3) and the negatively charged polyinosinic : polycytidylic acid (Poly(I : C)), followed by RBC membrane encapsulation. P2-PPh3 is an AIE-active conjugated polyelectrolyte with additional photosensitizing ability for photodynamic therapy (PDT), while Poly(I : C) serves as an immune-stimulant to stimulate both tumor and immune cells to activate immunity, and thus reduces tumor cell viability. When applied in tumor-bearing mice, the M@AP NPs are enriched in both the tumor region as a result of an enhanced permeability and retention (EPR) effect, and the spleen because of the homing effect of the RBC-mimicking shell. Upon light irradiation, P2-PPh3 promotes strong ROS generation in tumor cells, inducing the release of tumor antigens (TA). The anti-tumor immunity is further enhanced by the presence of Poly(I : C) in M@AP. Thus, this strategy combines the PDT properties of the AIE-active polyelectrolyte and immunotherapy properties of Poly(I : C) to achieve synergistic activation of the immune system for anti-tumor activity, providing a novel strategy for tumor treatment. Oxford University Press 2021-03-03 /pmc/articles/PMC8288176/ /pubmed/34691671 http://dx.doi.org/10.1093/nsr/nwab039 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle CHEMISTRY
Dai, Jun
Wu, Meng
Wang, Quan
Ding, Siyang
Dong, Xiaoqi
Xue, Liru
Zhu, Qingqing
Zhou, Jian
Xia, Fan
Wang, Shixuan
Hong, Yuning
Red blood cell membrane-camouflaged nanoparticles loaded with AIEgen and Poly(I : C) for enhanced tumoral photodynamic-immunotherapy
title Red blood cell membrane-camouflaged nanoparticles loaded with AIEgen and Poly(I : C) for enhanced tumoral photodynamic-immunotherapy
title_full Red blood cell membrane-camouflaged nanoparticles loaded with AIEgen and Poly(I : C) for enhanced tumoral photodynamic-immunotherapy
title_fullStr Red blood cell membrane-camouflaged nanoparticles loaded with AIEgen and Poly(I : C) for enhanced tumoral photodynamic-immunotherapy
title_full_unstemmed Red blood cell membrane-camouflaged nanoparticles loaded with AIEgen and Poly(I : C) for enhanced tumoral photodynamic-immunotherapy
title_short Red blood cell membrane-camouflaged nanoparticles loaded with AIEgen and Poly(I : C) for enhanced tumoral photodynamic-immunotherapy
title_sort red blood cell membrane-camouflaged nanoparticles loaded with aiegen and poly(i : c) for enhanced tumoral photodynamic-immunotherapy
topic CHEMISTRY
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288176/
https://www.ncbi.nlm.nih.gov/pubmed/34691671
http://dx.doi.org/10.1093/nsr/nwab039
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