Cargando…

Novel Scalable and Simplified System to Generate Microglia-Containing Cerebral Organoids From Human Induced Pluripotent Stem Cells

Human cerebral organoid (CO) is a three-dimensional (3D) cell culture system that recapitulates the developing human brain. While CO has proved an invaluable tool for studying neurological disorders in a more clinically relevant matter, there have still been several shortcomings including CO variabi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bodnar, Brittany, Zhang, Yongang, Liu, Jinbiao, Lin, Yuan, Wang, Peng, Wei, Zhengyu, Saribas, Sami, Zhu, Yuanjun, Li, Fang, Wang, Xu, Yang, Wenli, Li, Qingsheng, Ho, Wen-Zhe, Hu, Wenhui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cellular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288463/ https://www.ncbi.nlm.nih.gov/pubmed/34290591 http://dx.doi.org/10.3389/fncel.2021.682272

Ejemplares similares

Microglia-Specific Promoter Activities of HEXB Gene
por: Shah, Sahil, et al.
Publicado: (2022)

Protein expression/secretion boost by a novel unique 21-mer cis-regulatory motif (Exin21) via mRNA stabilization
por: Zhu, Yuanjun, et al.
Publicado: (2023)

A simplified protocol for the generation of cortical brain organoids
por: Eigenhuis, Kristel N., et al.
Publicado: (2023)

Epigallocatechin gallate from green tea effectively blocks infection of SARS-CoV-2 and new variants by inhibiting spike binding to ACE2 receptor
por: Liu, Jinbiao, et al.
Publicado: (2021)

Replacement of Mouse Microglia With Human Induced Pluripotent Stem Cell (hiPSC)-Derived Microglia in Mouse Organotypic Slice Cultures
por: Ogaki, Ari, et al.
Publicado: (2022)

Nicotinamide Promotes Formation of Retinal Organoids From Human Pluripotent Stem Cells via Enhanced Neural Cell Fate Commitment
por: Regent, Florian, et al.
Publicado: (2022)

Emerging Roles of Microglia in Neuro-vascular Unit: Implications of Microglia-Neurons Interactions
por: Ding, Zhe, et al.
Publicado: (2021)

Long Term Gene Expression in Human Induced Pluripotent Stem Cells and Cerebral Organoids to Model a Neurodegenerative Disease
por: Nassor, Ferid, et al.
Publicado: (2020)

Development and validation of a simplified method to generate human microglia from pluripotent stem cells
por: McQuade, Amanda, et al.
Publicado: (2018)

Microglia and Microglia-Like Cells: Similar but Different
por: Cuadros, Miguel A., et al.
Publicado: (2022)

A simplified and scalable synthesis of artesunate
por: Presser, Armin, et al.
Publicado: (2016)

Microglia-containing cerebral organoids derived from induced pluripotent stem cells for the study of neurological diseases
por: Hong, Yiling, et al.
Publicado: (2023)

Incorporating microglia‐like cells in human induced pluripotent stem cell‐derived retinal organoids
por: Chichagova, Valeria, et al.
Publicado: (2023)

Corrigendum: Retinal Organoids: Cultivation, Differentiation, and Transplantation
por: Li, Xuying, et al.
Publicado: (2021)

Editorial: Blood microbiota in health and disease
por: Demirci, Mehmet, et al.
Publicado: (2023)

Microglia in Alzheimer’s Disease: A Target for Therapeutic Intervention
por: Zhang, Guimei, et al.
Publicado: (2021)

Regulation of microglia phagocytosis and potential involvement of exercise
por: Li, Congqin, et al.
Publicado: (2022)

Scalable generation of 3D pancreatic islet organoids from human pluripotent stem cells in suspension bioreactors
por: Pollock, Samuel D., et al.
Publicado: (2023)

Scalable generation of 3D pancreatic islet organoids from human pluripotent stem cells in suspension bioreactors
por: Pollock, Samuel D., et al.
Publicado: (2023)

Genetic Modification of Brain Organoids
por: Fischer, Jan, et al.
Publicado: (2019)

Simplifying the development of portable, scalable, and reproducible workflows
por: Piccolo, Stephen R, et al.
Publicado: (2021)

Replenished microglia partially rescue schizophrenia-related stress response
por: Yan, Ling, et al.
Publicado: (2023)

Microglia-mediated neuroinflammation and neuroplasticity after stroke
por: Wang, Yuan, et al.
Publicado: (2022)

Correlation of vaccine‐elicited antibody levels and neutralizing activities against SARS‐CoV‐2 and its variants
por: Liu, Jinbiao, et al.
Publicado: (2021)

Editorial: Brain Organoids: Modeling in Neuroscience
por: Bordoni, Matteo, et al.
Publicado: (2020)

Kidney micro-organoids in suspension culture as a scalable source of human pluripotent stem cell-derived kidney cells
por: Kumar, Santhosh V., et al.
Publicado: (2019)

Microglia Regulate Neuronal Circuits in Homeostatic and High-Fat Diet-Induced Inflammatory Conditions
por: Wang, Xiao-Lan, et al.
Publicado: (2021)

Editorial: Cell biology of microglia
por: Sepúlveda, M. Rosario, et al.
Publicado: (2023)

What microglia depletion approaches tell us about the role of microglia on synaptic function and behavior
por: Basilico, Bernadette, et al.
Publicado: (2022)

Organoid Models of Glioblastoma and Their Role in Drug Discovery
por: Rybin, Matthew J., et al.
Publicado: (2021)

Organoids for the Study of Retinal Development and Developmental Abnormalities
por: Vielle, Anne, et al.
Publicado: (2021)

Microglia and Their Promising Role in Ischemic Brain Injuries: An Update
por: Yu, Luting, et al.
Publicado: (2020)

Gene Editing in Pluripotent Stem Cells and Their Derived Organoids
por: Zhou, Hang, et al.
Publicado: (2021)

Developing human pluripotent stem cell-based cerebral organoids with a controllable microglia ratio for modeling brain development and pathology
por: Xu, Ranjie, et al.
Publicado: (2021)

The Role of Microglia in Perioperative Neurocognitive Disorders
por: Fan, Wenguo, et al.
Publicado: (2020)

Attack of the Clones: Microglia in Health and Disease
por: Manjally, Amritha Vinayak, et al.
Publicado: (2022)

Editorial: Dysfunctional microglia in neurological disorders
por: Bhusal, Anup, et al.
Publicado: (2023)

Microglia Don’t Treat All Neurons the Same: The Importance of Neuronal Subtype in Microglia-Neuron Interactions in the Developing Hypothalamus
por: Ngozi, Zuri, et al.
Publicado: (2022)

Rapid and Efficient Generation of Myelinating Human Oligodendrocytes in Organoids
por: Shaker, Mohammed R., et al.
Publicado: (2021)

Microglia Gone Awry: Linking Immunometabolism to Neurodegeneration
por: Afridi, Ruqayya, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_tn77fsfl0r4d2q9fd3r6n6jop3