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Detection of Human Papillomavirus in Papillary Thyroid Carcinoma and its Association with Tumor Staging and Pathologic Features

BACKGROUND: The role of human papillomavirus (HPV), as a common infection, has been evaluated in many cancers such as the cervix and squamous cell carcinoma of the head and neck. To the best of our knowledge, for the first time, the association of HPV with papillary thyroid carcinoma (PTC) and its p...

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Autores principales: Archin Dialameh, Pardisa, Saki, Forough, Monabbati, Ahmad, Dehghanian, Amirreza, Valibeigi, Behnaz, Soveid, Mahmood
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shiraz University of Medical Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288493/
https://www.ncbi.nlm.nih.gov/pubmed/34305237
http://dx.doi.org/10.30476/ijms.2020.83135.1191
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author Archin Dialameh, Pardisa
Saki, Forough
Monabbati, Ahmad
Dehghanian, Amirreza
Valibeigi, Behnaz
Soveid, Mahmood
author_facet Archin Dialameh, Pardisa
Saki, Forough
Monabbati, Ahmad
Dehghanian, Amirreza
Valibeigi, Behnaz
Soveid, Mahmood
author_sort Archin Dialameh, Pardisa
collection PubMed
description BACKGROUND: The role of human papillomavirus (HPV), as a common infection, has been evaluated in many cancers such as the cervix and squamous cell carcinoma of the head and neck. To the best of our knowledge, for the first time, the association of HPV with papillary thyroid carcinoma (PTC) and its pathologic features are investigated. METHODS: A retrospective cross-sectional study was conducted from May 2014 to January 2018 in several hospitals affiliated to Shiraz University of Medical Sciences, Shiraz, Iran. Thyroid tissue specimens of patients diagnosed with PTC (n=82) and benign thyroid nodules (n=77) were collected using the consecutive sampling method. The presence of HPV in PTC, adjacent normal tissue, and benign thyroid nodules was evaluated using the polymerase chain reaction (PCR) method. The frequency of HPV positivity in PTC tissues was compared with benign thyroid nodules and adjacent normal tissue. Association of pathologic features of PTC with HPV positivity was also investigated. Data were analyzed using SPSS version 21.0, and P values less than 0.05 were considered statistically significant. RESULTS: HPV PCR positivity was observed in 3.8% of benign thyroid nodules and 13.4% of PTC samples but in none of the adjacent normal tissues. After adjustment for age and sex, the prevalence of HPV PCR positivity in the PTC tissues was significantly more than the benign thyroid nodules (P=0.015). The prevalence was also significantly higher than the adjacent normal tissues (P<0.001). CONCLUSION: There was a significant association between PTC and HPV positivity. Further studies are required to determine the cause and effect of the association between these two conditions.
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spelling pubmed-82884932021-07-23 Detection of Human Papillomavirus in Papillary Thyroid Carcinoma and its Association with Tumor Staging and Pathologic Features Archin Dialameh, Pardisa Saki, Forough Monabbati, Ahmad Dehghanian, Amirreza Valibeigi, Behnaz Soveid, Mahmood Iran J Med Sci Original Article BACKGROUND: The role of human papillomavirus (HPV), as a common infection, has been evaluated in many cancers such as the cervix and squamous cell carcinoma of the head and neck. To the best of our knowledge, for the first time, the association of HPV with papillary thyroid carcinoma (PTC) and its pathologic features are investigated. METHODS: A retrospective cross-sectional study was conducted from May 2014 to January 2018 in several hospitals affiliated to Shiraz University of Medical Sciences, Shiraz, Iran. Thyroid tissue specimens of patients diagnosed with PTC (n=82) and benign thyroid nodules (n=77) were collected using the consecutive sampling method. The presence of HPV in PTC, adjacent normal tissue, and benign thyroid nodules was evaluated using the polymerase chain reaction (PCR) method. The frequency of HPV positivity in PTC tissues was compared with benign thyroid nodules and adjacent normal tissue. Association of pathologic features of PTC with HPV positivity was also investigated. Data were analyzed using SPSS version 21.0, and P values less than 0.05 were considered statistically significant. RESULTS: HPV PCR positivity was observed in 3.8% of benign thyroid nodules and 13.4% of PTC samples but in none of the adjacent normal tissues. After adjustment for age and sex, the prevalence of HPV PCR positivity in the PTC tissues was significantly more than the benign thyroid nodules (P=0.015). The prevalence was also significantly higher than the adjacent normal tissues (P<0.001). CONCLUSION: There was a significant association between PTC and HPV positivity. Further studies are required to determine the cause and effect of the association between these two conditions. Shiraz University of Medical Sciences 2021-07 /pmc/articles/PMC8288493/ /pubmed/34305237 http://dx.doi.org/10.30476/ijms.2020.83135.1191 Text en Copyright: © Iranian Journal of Medical Sciences https://creativecommons.org/licenses/by-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 4.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Archin Dialameh, Pardisa
Saki, Forough
Monabbati, Ahmad
Dehghanian, Amirreza
Valibeigi, Behnaz
Soveid, Mahmood
Detection of Human Papillomavirus in Papillary Thyroid Carcinoma and its Association with Tumor Staging and Pathologic Features
title Detection of Human Papillomavirus in Papillary Thyroid Carcinoma and its Association with Tumor Staging and Pathologic Features
title_full Detection of Human Papillomavirus in Papillary Thyroid Carcinoma and its Association with Tumor Staging and Pathologic Features
title_fullStr Detection of Human Papillomavirus in Papillary Thyroid Carcinoma and its Association with Tumor Staging and Pathologic Features
title_full_unstemmed Detection of Human Papillomavirus in Papillary Thyroid Carcinoma and its Association with Tumor Staging and Pathologic Features
title_short Detection of Human Papillomavirus in Papillary Thyroid Carcinoma and its Association with Tumor Staging and Pathologic Features
title_sort detection of human papillomavirus in papillary thyroid carcinoma and its association with tumor staging and pathologic features
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288493/
https://www.ncbi.nlm.nih.gov/pubmed/34305237
http://dx.doi.org/10.30476/ijms.2020.83135.1191
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