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The Interrelationship between Liver Function Test and the Coronavirus Disease 2019: A Systematic Review and Meta-Analysis

BACKGROUND: The outbreak of the coronavirus disease-2019 (COVID-19) has become a global public health challenge. Assessing the effect of COVID-19 on liver injury is of great importance. A systematic review and meta-analysis were conducted to establish the characteristics of liver function tests in C...

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Autores principales: Zahedi, Mohammad, Yousefi, Mohammad, Abounoori, Mahdi, Malekan, Mohammad, Tajik, Fatemeh, Heydari, Keyvan, Mortazavi, Parham, Ghahramani, Sulmaz, Ghazaeian, Monireh, Sheydaee, Fateme, Nasirzadeh, Amirreza, Alizadeh-Navaei, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shiraz University of Medical Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288495/
https://www.ncbi.nlm.nih.gov/pubmed/34305236
http://dx.doi.org/10.30476/ijms.2021.87555.1793
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author Zahedi, Mohammad
Yousefi, Mohammad
Abounoori, Mahdi
Malekan, Mohammad
Tajik, Fatemeh
Heydari, Keyvan
Mortazavi, Parham
Ghahramani, Sulmaz
Ghazaeian, Monireh
Sheydaee, Fateme
Nasirzadeh, Amirreza
Alizadeh-Navaei, Reza
author_facet Zahedi, Mohammad
Yousefi, Mohammad
Abounoori, Mahdi
Malekan, Mohammad
Tajik, Fatemeh
Heydari, Keyvan
Mortazavi, Parham
Ghahramani, Sulmaz
Ghazaeian, Monireh
Sheydaee, Fateme
Nasirzadeh, Amirreza
Alizadeh-Navaei, Reza
author_sort Zahedi, Mohammad
collection PubMed
description BACKGROUND: The outbreak of the coronavirus disease-2019 (COVID-19) has become a global public health challenge. Assessing the effect of COVID-19 on liver injury is of great importance. A systematic review and meta-analysis were conducted to establish the characteristics of liver function tests in COVID-19 patients. METHODS: A systematic search of publications from December 2019 up to April 2020 in Web of Science, Scopus, and Medline (via PubMed) databases was performed. Both cross-sectional and case series studies reporting an association between liver injury and COVID-19 infection were included. The data were analyzed using the STATA software (version 11.0) and the random-effects model for I(2)>50% was used to pool the results. RESULTS: In this meta-analysis, 42 articles comprising a total of 6,557 COVID-19 patients were studied. The prevalence of increase in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels was 30% and 21% in non-severe patients and 38% and 48% in severe patients, respectively. Patients with severe COVID-19 infection were 4.22, 4.96, and 4.13 times more likely to have elevated AST, ALT, and lactate dehydrogenase (LDH) levels, respectively. CONCLUSION: Elevation in liver function tests was higher in patients with severe than non-severe COVID-19 infection. Given the widespread use of drugs that increases the risk of hepatotoxicity, healthcare providers should be aware of changes in liver enzymes in COVID-19 patients. The inclusion of other studies from outside China could confirm the pattern of elevation in liver function tests in COVID-19 patients across the globe. Preprint of this article is available on medRxiv, https://www.medrxiv.org/content/10.1101/2020.05.20.20108357v1
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spelling pubmed-82884952021-07-23 The Interrelationship between Liver Function Test and the Coronavirus Disease 2019: A Systematic Review and Meta-Analysis Zahedi, Mohammad Yousefi, Mohammad Abounoori, Mahdi Malekan, Mohammad Tajik, Fatemeh Heydari, Keyvan Mortazavi, Parham Ghahramani, Sulmaz Ghazaeian, Monireh Sheydaee, Fateme Nasirzadeh, Amirreza Alizadeh-Navaei, Reza Iran J Med Sci Review Article BACKGROUND: The outbreak of the coronavirus disease-2019 (COVID-19) has become a global public health challenge. Assessing the effect of COVID-19 on liver injury is of great importance. A systematic review and meta-analysis were conducted to establish the characteristics of liver function tests in COVID-19 patients. METHODS: A systematic search of publications from December 2019 up to April 2020 in Web of Science, Scopus, and Medline (via PubMed) databases was performed. Both cross-sectional and case series studies reporting an association between liver injury and COVID-19 infection were included. The data were analyzed using the STATA software (version 11.0) and the random-effects model for I(2)>50% was used to pool the results. RESULTS: In this meta-analysis, 42 articles comprising a total of 6,557 COVID-19 patients were studied. The prevalence of increase in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels was 30% and 21% in non-severe patients and 38% and 48% in severe patients, respectively. Patients with severe COVID-19 infection were 4.22, 4.96, and 4.13 times more likely to have elevated AST, ALT, and lactate dehydrogenase (LDH) levels, respectively. CONCLUSION: Elevation in liver function tests was higher in patients with severe than non-severe COVID-19 infection. Given the widespread use of drugs that increases the risk of hepatotoxicity, healthcare providers should be aware of changes in liver enzymes in COVID-19 patients. The inclusion of other studies from outside China could confirm the pattern of elevation in liver function tests in COVID-19 patients across the globe. Preprint of this article is available on medRxiv, https://www.medrxiv.org/content/10.1101/2020.05.20.20108357v1 Shiraz University of Medical Sciences 2021-07 /pmc/articles/PMC8288495/ /pubmed/34305236 http://dx.doi.org/10.30476/ijms.2021.87555.1793 Text en Copyright: © Iranian Journal of Medical Sciences https://creativecommons.org/licenses/by-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 4.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zahedi, Mohammad
Yousefi, Mohammad
Abounoori, Mahdi
Malekan, Mohammad
Tajik, Fatemeh
Heydari, Keyvan
Mortazavi, Parham
Ghahramani, Sulmaz
Ghazaeian, Monireh
Sheydaee, Fateme
Nasirzadeh, Amirreza
Alizadeh-Navaei, Reza
The Interrelationship between Liver Function Test and the Coronavirus Disease 2019: A Systematic Review and Meta-Analysis
title The Interrelationship between Liver Function Test and the Coronavirus Disease 2019: A Systematic Review and Meta-Analysis
title_full The Interrelationship between Liver Function Test and the Coronavirus Disease 2019: A Systematic Review and Meta-Analysis
title_fullStr The Interrelationship between Liver Function Test and the Coronavirus Disease 2019: A Systematic Review and Meta-Analysis
title_full_unstemmed The Interrelationship between Liver Function Test and the Coronavirus Disease 2019: A Systematic Review and Meta-Analysis
title_short The Interrelationship between Liver Function Test and the Coronavirus Disease 2019: A Systematic Review and Meta-Analysis
title_sort interrelationship between liver function test and the coronavirus disease 2019: a systematic review and meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288495/
https://www.ncbi.nlm.nih.gov/pubmed/34305236
http://dx.doi.org/10.30476/ijms.2021.87555.1793
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