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Engrailed 1 coordinates cytoskeletal reorganization to induce myofibroblast differentiation

Transforming growth factor-β (TGFβ) is a key mediator of fibroblast activation in fibrotic diseases, including systemic sclerosis. Here we show that Engrailed 1 (EN1) is reexpressed in multiple fibroblast subpopulations in the skin of SSc patients. We characterize EN1 as a molecular amplifier of TGF...

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Detalles Bibliográficos
Autores principales:	Györfi, Andrea-Hermina, Matei, Alexandru-Emil, Fuchs, Maximilian, Liang, Chunguang, Rigau, Aleix Rius, Hong, Xuezhi, Zhu, Honglin, Luber, Markus, Bergmann, Christina, Dees, Clara, Ludolph, Ingo, Horch, Raymund E., Distler, Oliver, Wang, Jiucun, Bengsch, Bertram, Schett, Georg, Kunz, Meik, Distler, Jörg H.W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288503/ https://www.ncbi.nlm.nih.gov/pubmed/34259830 http://dx.doi.org/10.1084/jem.20201916

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