Xanthomas Regression in an 8-Year-Old Boy Treated With Lomitapide

This case reports on an 8-year-old boy with homozygous familial hypercholesterolemia with large tuberous xanthomas over his hands, elbows, buttocks, knees, and feet. Lomitapide 40 mg daily (steadily increased) was added to his classical lipid-lowering therapy. A 50% reduction in the thickness, hardn...

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Detalles Bibliográficos
Autores principales: Kolovou, Genovefa, Tsoutsinos, Aleksandros, Mastorakou, Irene, Mavrogeni, Sophie, Hatzigeorgiou, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Imaging Vignette
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288695/
https://www.ncbi.nlm.nih.gov/pubmed/34316840
http://dx.doi.org/10.1016/j.jaccas.2019.06.029
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author Kolovou, Genovefa
Tsoutsinos, Aleksandros
Mastorakou, Irene
Mavrogeni, Sophie
Hatzigeorgiou, George
author_facet Kolovou, Genovefa
Tsoutsinos, Aleksandros
Mastorakou, Irene
Mavrogeni, Sophie
Hatzigeorgiou, George
author_sort Kolovou, Genovefa
collection PubMed
description This case reports on an 8-year-old boy with homozygous familial hypercholesterolemia with large tuberous xanthomas over his hands, elbows, buttocks, knees, and feet. Lomitapide 40 mg daily (steadily increased) was added to his classical lipid-lowering therapy. A 50% reduction in the thickness, hardness, size, and color intensity of xanthomas was reported after 2 years of treatment. (Level of Difficulty: Intermediate.)
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spelling pubmed-82886952021-07-26 Xanthomas Regression in an 8-Year-Old Boy Treated With Lomitapide Kolovou, Genovefa Tsoutsinos, Aleksandros Mastorakou, Irene Mavrogeni, Sophie Hatzigeorgiou, George JACC Case Rep Imaging Vignette This case reports on an 8-year-old boy with homozygous familial hypercholesterolemia with large tuberous xanthomas over his hands, elbows, buttocks, knees, and feet. Lomitapide 40 mg daily (steadily increased) was added to his classical lipid-lowering therapy. A 50% reduction in the thickness, hardness, size, and color intensity of xanthomas was reported after 2 years of treatment. (Level of Difficulty: Intermediate.) Elsevier 2019-09-04 /pmc/articles/PMC8288695/ /pubmed/34316840 http://dx.doi.org/10.1016/j.jaccas.2019.06.029 Text en © 2019 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Imaging Vignette
Kolovou, Genovefa
Tsoutsinos, Aleksandros
Mastorakou, Irene
Mavrogeni, Sophie
Hatzigeorgiou, George
Xanthomas Regression in an 8-Year-Old Boy Treated With Lomitapide
title Xanthomas Regression in an 8-Year-Old Boy Treated With Lomitapide
title_full Xanthomas Regression in an 8-Year-Old Boy Treated With Lomitapide
title_fullStr Xanthomas Regression in an 8-Year-Old Boy Treated With Lomitapide
title_full_unstemmed Xanthomas Regression in an 8-Year-Old Boy Treated With Lomitapide
title_short Xanthomas Regression in an 8-Year-Old Boy Treated With Lomitapide
title_sort xanthomas regression in an 8-year-old boy treated with lomitapide
topic Imaging Vignette
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288695/
https://www.ncbi.nlm.nih.gov/pubmed/34316840
http://dx.doi.org/10.1016/j.jaccas.2019.06.029
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AT mavrogenisophie xanthomasregressioninan8yearoldboytreatedwithlomitapide
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