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Targeting neurons in the gastrointestinal tract to treat Parkinson's disease()

BACKGROUND: Parkinson's disease (PD) is associated with α-synuclein (αS) aggregation within the enteric nervous system (ENS) and constipation. Squalamine displaces proteins that are electrostatically bound to intracellular membranes and through this mechanism suppresses aggregation of αS monome...

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Detalles Bibliográficos
Autores principales:	Hauser, Robert A., Sutherland, Dean, Madrid, Juan A., Rol, Maria Angeles, Frucht, Steven, Isaacson, Stuart, Pagan, Fernando, Maddux, Brian N., Li, George, Tse, Winona, Walter, Benjamin L., Kumar, Rajeev, Kremens, Daniel, Lew, Mark F., Ellenbogen, Aaron, Oguh, Odinachi, Vasquez, Alberto, Kinney, William, Lowery, Matt, Resnick, Maria, Huff, Nicole, Posner, Jerry, Ballman, Karla V., Harvey, Brian E., Camilleri, Michael, Zasloff, Michael, Barbut, Denise
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288812/ https://www.ncbi.nlm.nih.gov/pubmed/34316590 http://dx.doi.org/10.1016/j.prdoa.2019.06.001

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