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Validating the Vietnamese version of wearing – Off 19 questionnaire for patients with Parkinson's disease

BACKGROUND: One of the most common complication of the progression of Parkinson's disease (PD) is the wearing off phenomenon. A validated Vietnamese version of Wearing off 19 (WO19) questionnaire is necessary to optimize the Vietnamese PD treatment. OBJECTIVES: This study was undertaken to dete...

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Autores principales: Ha, Uyen Le Ngoc, Tran, Tai Ngoc, Le, Minh, Dang, Thuong Huyen Thi, Vũ, Nhi Anh, Truong, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288827/
https://www.ncbi.nlm.nih.gov/pubmed/34316597
http://dx.doi.org/10.1016/j.prdoa.2019.07.007
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author Ha, Uyen Le Ngoc
Tran, Tai Ngoc
Le, Minh
Dang, Thuong Huyen Thi
Vũ, Nhi Anh
Truong, Daniel
author_facet Ha, Uyen Le Ngoc
Tran, Tai Ngoc
Le, Minh
Dang, Thuong Huyen Thi
Vũ, Nhi Anh
Truong, Daniel
author_sort Ha, Uyen Le Ngoc
collection PubMed
description BACKGROUND: One of the most common complication of the progression of Parkinson's disease (PD) is the wearing off phenomenon. A validated Vietnamese version of Wearing off 19 (WO19) questionnaire is necessary to optimize the Vietnamese PD treatment. OBJECTIVES: This study was undertaken to determine the quality attribute of the questionnaire as a tool for early detection of wearing off (WO) in Vietnamese population with PD. We also sought the relationship between the WO phenomenon and factors concerning the clinical condition and course of the disease. SUBJECTS AND METHODS: This is an observational, cross-sectional study. Patients diagnosed with PD under dopaminergic treatment came to University Medical Center Ho Chi Minh city for a regular appointment were sequentially asked to complete the Vietnamese WO19 questionnaire. A neurologist specialized in movement disorders assessed the patient and determined whether he had experienced wearing off or not. The questionnaire results were then compared to the clinical opinion of the expert which is considered the gold standard for diagnosing wearing off. The reliability of the questionnaire is evaluated by Cronbach'α and Cohen’s kappa coefficient. The validity is measured by the sensitivity and the specificity of the instrument compared to the gold standard. The multivariate logistic regression analysis is used to learn the relations of associated factors and wearing off phenomenon. RESULTS: 98 patients with the mean age 59.12 ± 10.99 have joined our study; 58.2% are male; and the mean disease duration is 6.32 years. The Vietnamese version of the WO19 questionnaire has a good reliability (Cronbach'α = 0.778) and the agreement with the expert assessment (the diagnostic accuracy) is at a substantial level (Kappa value = 0.618). The sensitivity and specificity of the questionnaire resulted 89.28% and 71.43% respectively. The multivariate logistic regression analysis revealed a long disease duration (≥6 years) (OR: 16.96; 95% CI: 2.17–132.57; p = 0.007), a high daily levodopa dosage (≥400 mg/day) (OR: 6.31; 95% CI: 1.36–29.23; p = 0.019) and high score of MDS-UPDRS part IV (≥4) (OR: 15.36; 95% CI: 2.13–110.58; p = 0.007) were independent predictive factors for wearing off in Vietnamese PD patients. CONCLUSIONS: Vietnamese – WO19 is a reliable and effective tool which should be used in clinical practice for early detecting PD patients with wearing off.
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spelling pubmed-82888272021-07-26 Validating the Vietnamese version of wearing – Off 19 questionnaire for patients with Parkinson's disease Ha, Uyen Le Ngoc Tran, Tai Ngoc Le, Minh Dang, Thuong Huyen Thi Vũ, Nhi Anh Truong, Daniel Clin Park Relat Disord Original Article BACKGROUND: One of the most common complication of the progression of Parkinson's disease (PD) is the wearing off phenomenon. A validated Vietnamese version of Wearing off 19 (WO19) questionnaire is necessary to optimize the Vietnamese PD treatment. OBJECTIVES: This study was undertaken to determine the quality attribute of the questionnaire as a tool for early detection of wearing off (WO) in Vietnamese population with PD. We also sought the relationship between the WO phenomenon and factors concerning the clinical condition and course of the disease. SUBJECTS AND METHODS: This is an observational, cross-sectional study. Patients diagnosed with PD under dopaminergic treatment came to University Medical Center Ho Chi Minh city for a regular appointment were sequentially asked to complete the Vietnamese WO19 questionnaire. A neurologist specialized in movement disorders assessed the patient and determined whether he had experienced wearing off or not. The questionnaire results were then compared to the clinical opinion of the expert which is considered the gold standard for diagnosing wearing off. The reliability of the questionnaire is evaluated by Cronbach'α and Cohen’s kappa coefficient. The validity is measured by the sensitivity and the specificity of the instrument compared to the gold standard. The multivariate logistic regression analysis is used to learn the relations of associated factors and wearing off phenomenon. RESULTS: 98 patients with the mean age 59.12 ± 10.99 have joined our study; 58.2% are male; and the mean disease duration is 6.32 years. The Vietnamese version of the WO19 questionnaire has a good reliability (Cronbach'α = 0.778) and the agreement with the expert assessment (the diagnostic accuracy) is at a substantial level (Kappa value = 0.618). The sensitivity and specificity of the questionnaire resulted 89.28% and 71.43% respectively. The multivariate logistic regression analysis revealed a long disease duration (≥6 years) (OR: 16.96; 95% CI: 2.17–132.57; p = 0.007), a high daily levodopa dosage (≥400 mg/day) (OR: 6.31; 95% CI: 1.36–29.23; p = 0.019) and high score of MDS-UPDRS part IV (≥4) (OR: 15.36; 95% CI: 2.13–110.58; p = 0.007) were independent predictive factors for wearing off in Vietnamese PD patients. CONCLUSIONS: Vietnamese – WO19 is a reliable and effective tool which should be used in clinical practice for early detecting PD patients with wearing off. Elsevier 2019-08-05 /pmc/articles/PMC8288827/ /pubmed/34316597 http://dx.doi.org/10.1016/j.prdoa.2019.07.007 Text en © 2019 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Ha, Uyen Le Ngoc
Tran, Tai Ngoc
Le, Minh
Dang, Thuong Huyen Thi
Vũ, Nhi Anh
Truong, Daniel
Validating the Vietnamese version of wearing – Off 19 questionnaire for patients with Parkinson's disease
title Validating the Vietnamese version of wearing – Off 19 questionnaire for patients with Parkinson's disease
title_full Validating the Vietnamese version of wearing – Off 19 questionnaire for patients with Parkinson's disease
title_fullStr Validating the Vietnamese version of wearing – Off 19 questionnaire for patients with Parkinson's disease
title_full_unstemmed Validating the Vietnamese version of wearing – Off 19 questionnaire for patients with Parkinson's disease
title_short Validating the Vietnamese version of wearing – Off 19 questionnaire for patients with Parkinson's disease
title_sort validating the vietnamese version of wearing – off 19 questionnaire for patients with parkinson's disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288827/
https://www.ncbi.nlm.nih.gov/pubmed/34316597
http://dx.doi.org/10.1016/j.prdoa.2019.07.007
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