MKRN3 regulates the epigenetic switch of mammalian puberty via ubiquitination of MBD3

Central precocious puberty (CPP) refers to a human syndrome of early puberty initiation with characteristic increase in hypothalamic production and release of gonadotropin-releasing hormone (GnRH). Previously, loss-of-function mutations in human MKRN3, encoding a putative E3 ubiquitin ligase, were f...

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Detalles Bibliográficos
Autores principales: Li, Chuanyin, Lu, Wenli, Yang, Liguang, Li, Zhengwei, Zhou, Xiaoyi, Guo, Rong, Wang, Junqi, Wu, Zhebao, Dong, Zhiya, Ning, Guang, Shi, Yujiang, Gu, Yinmin, Chen, Peng, Hao, Zijian, Han, Tianting, Yang, Meiqiang, Wang, Wei, Huang, Xuehui, Li, Yixue, Gao, Shan, Hu, Ronggui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288866/
https://www.ncbi.nlm.nih.gov/pubmed/34692086
http://dx.doi.org/10.1093/nsr/nwaa023

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