Why does caloric restriction increase life and healthspan? The ‘clean cupboards’ hypothesis

The disposable soma hypothesis explanation of the effects of caloric restriction (CR) on lifespan fails to explain why CR generates negative impacts alongside the positive effects and does not work in all species. I propose here a novel idea called the clean cupboards hypothesis which overcomes thes...

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Detalles Bibliográficos
Autor principal: Speakman, John R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288867/
https://www.ncbi.nlm.nih.gov/pubmed/34692140
http://dx.doi.org/10.1093/nsr/nwaa078
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author Speakman, John R
author_facet Speakman, John R
author_sort Speakman, John R
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description The disposable soma hypothesis explanation of the effects of caloric restriction (CR) on lifespan fails to explain why CR generates negative impacts alongside the positive effects and does not work in all species. I propose here a novel idea called the clean cupboards hypothesis which overcomes these problems.
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spelling pubmed-82888672021-10-21 Why does caloric restriction increase life and healthspan? The ‘clean cupboards’ hypothesis Speakman, John R Natl Sci Rev Perspectives The disposable soma hypothesis explanation of the effects of caloric restriction (CR) on lifespan fails to explain why CR generates negative impacts alongside the positive effects and does not work in all species. I propose here a novel idea called the clean cupboards hypothesis which overcomes these problems. Oxford University Press 2020-07 2020-04-29 /pmc/articles/PMC8288867/ /pubmed/34692140 http://dx.doi.org/10.1093/nsr/nwaa078 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Perspectives
Speakman, John R
Why does caloric restriction increase life and healthspan? The ‘clean cupboards’ hypothesis
title Why does caloric restriction increase life and healthspan? The ‘clean cupboards’ hypothesis
title_full Why does caloric restriction increase life and healthspan? The ‘clean cupboards’ hypothesis
title_fullStr Why does caloric restriction increase life and healthspan? The ‘clean cupboards’ hypothesis
title_full_unstemmed Why does caloric restriction increase life and healthspan? The ‘clean cupboards’ hypothesis
title_short Why does caloric restriction increase life and healthspan? The ‘clean cupboards’ hypothesis
title_sort why does caloric restriction increase life and healthspan? the ‘clean cupboards’ hypothesis
topic Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288867/
https://www.ncbi.nlm.nih.gov/pubmed/34692140
http://dx.doi.org/10.1093/nsr/nwaa078
work_keys_str_mv AT speakmanjohnr whydoescaloricrestrictionincreaselifeandhealthspanthecleancupboardshypothesis

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