Quinazolin-derived myeloperoxidase inhibitor suppresses influenza A virus-induced reactive oxygen species, pro-inflammatory mediators and improves cell survival

Superoxide radicals and other reactive oxygen species (ROS) are implicated in influenza A virus-induced inflammation. In this in vitro study, we evaluated the effects of TG6-44, a novel quinazolin-derived myeloperoxidase-specific ROS inhibitor, on influenza A virus (A/X31) infection using THP-1 lung...

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Detalles Bibliográficos
Autores principales: De La Cruz, Juan A., Ganesh, Thota, Diebold, Becky A., Cao, Weiping, Hofstetter, Amelia, Singh, Neetu, Kumar, Amrita, McCoy, James, Ranjan, Priya, Smith, Susan M. E., Sambhara, Suryaprakash, Lambeth, J. David, Gangappa, Shivaprakash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289044/
https://www.ncbi.nlm.nih.gov/pubmed/34280220
http://dx.doi.org/10.1371/journal.pone.0254632

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