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Liquid–liquid phase separation of full-length prion protein initiates conformational conversion in vitro

Prion diseases are characterized by the accumulation of amyloid fibrils. The causative agent is an infectious amyloid that comprises solely misfolded prion protein (PrP(Sc)). Prions can convert normal cellular prion protein (PrP(C)) to protease K-resistance prion protein fragment (PrP-res) in vitro;...

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Detalles Bibliográficos
Autores principales:	Tange, Hiroya, Ishibashi, Daisuke, Nakagaki, Takehiro, Taguchi, Yuzuru, Kamatari, Yuji O., Ozawa, Hiroki, Nishida, Noriyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289115/ https://www.ncbi.nlm.nih.gov/pubmed/33545172 http://dx.doi.org/10.1016/j.jbc.2021.100367

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