Cargando…

An antipathogenic compound that targets the OxyR peroxide sensor in Pseudomonas aeruginosa

INTRODUCTION: Antipathogenic or antivirulence strategy is to target a virulence pathway that is dispensable for growth, in the hope to mitigate the selection for drug resistance. HYPOTHESIS/GAP STATMENT: Peroxide stress responses are one of the conserved virulence pathways in bacterial pathogens and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oh, Hyo-Young, Jalde, Shivakumar S., Chung, In-Young, Yoo, Yeon-Ji, Jang, Hye-Jeong, Choi, Hyun-Kyung, Cho, You-Hee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Microbiology Society 2021
Materias:	Prevention, Therapy and Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289212/ https://www.ncbi.nlm.nih.gov/pubmed/33830911 http://dx.doi.org/10.1099/jmm.0.001341

Ejemplares similares

An iron-chelating sulfonamide identified from Drosophila-based screening for antipathogenic discovery
por: Yoo, Yeon-Ji, et al.
Publicado: (2022)

Network pharmacology and molecular docking analysis on mechanisms of Tibetan Hongjingtian (Rhodiola crenulata) in the treatment of COVID-19
por: Wang, Li, et al.
Publicado: (2021)

Immunogenicity after the first dose of the BNT162b2 mRNA Covid-19 vaccine: real-world evidence from Greek healthcare workers
por: Kontopoulou, Konstantina, et al.
Publicado: (2021)

Clinical efficacy and safety of antifungal drugs for the treatment of Candida parapsilosis infections: a systematic review and network meta-analysis
por: Qin, Jielin, et al.
Publicado: (2021)

CPC-containing oral rinses inactivate SARS-CoV-2 variants and are active in the presence of human saliva
por: Anderson, Enyia R., et al.
Publicado: (2022)

Antipathogenic Compounds That Are Effective at Very Low Concentrations and Have Both Antibiofilm and Antivirulence Effects against Pseudomonas aeruginosa
por: Hwang, Hyeon-Ji, et al.
Publicado: (2021)

Oxidized OxyR Up-Regulates ahpCF Expression to Suppress Plating Defects of oxyR- and Catalase-Deficient Strains
por: Wan, Fen, et al.
Publicado: (2019)

In Silico and In Vitro Screening of Antipathogenic Properties of Melianthus comosus (Vahl) against Pseudomonas aeruginosa
por: Baloyi, Itumeleng T., et al.
Publicado: (2021)

A Novel OxyR Sensor and Regulator of Hydrogen Peroxide Stress with One Cysteine Residue in Deinococcus radiodurans
por: Chen, Huan, et al.
Publicado: (2008)

The OxyR-regulated phnW gene encoding 2-aminoethylphosphonate:pyruvate aminotransferase helps protect Pseudomonas aeruginosa from tert-butyl hydroperoxide
por: Panmanee, Warunya, et al.
Publicado: (2017)

Quorum quenching activity of Bacillus cereus isolate 30b confers antipathogenic effects in Pseudomonas aeruginosa
por: Raafat, Marwa M, et al.
Publicado: (2019)

OxyR Positively Influences Phaseolotoxin Synthesis and Pyoverdin Production in Pseudomonas savastanoi pv. phaseolicola NPS3121
por: Arvizu-Gómez, Jackeline Lizzeta, et al.
Publicado: (2022)

The structure of a reduced form of OxyR from Neisseria meningitidis
por: Sainsbury, Sarah, et al.
Publicado: (2010)

Loss of OxyR reduces efficacy of oxygen respiration in Shewanella oneidensis
por: Wan, Fen, et al.
Publicado: (2017)

OxyR-regulated catalase CatB promotes the virulence in rice via detoxifying hydrogen peroxide in Xanthomonas oryzae pv. oryzae
por: Yu, Chao, et al.
Publicado: (2016)

On the mechanism of tumor cell entry of aloe‐emodin, a natural compound endowed with anticancer activity
por: Pecere, Teresa, et al.
Publicado: (2021)

Influence of the Escherichia coli oxyR gene function on λ prophage maintenance
por: Glinkowska, Monika, et al.
Publicado: (2010)

Global regulation of gene expression by OxyR in an important human opportunistic pathogen
por: Wei, Qing, et al.
Publicado: (2012)

Role of oxygen and the OxyR protein in the response to iron limitation in Rhodobacter sphaeroides
por: Remes, Bernhard, et al.
Publicado: (2014)

Haemophilus influenzae OxyR: Characterization of Its Regulation, Regulon and Role in Fitness
por: Whitby, Paul W., et al.
Publicado: (2012)

Structural snapshots of OxyR reveal the peroxidatic mechanism of H(2)O(2) sensing
por: Pedre, Brandán, et al.
Publicado: (2018)

Monthly malaria chemoprevention shows potential in an area of very high, perennial malaria transmission
por: Cairns, Matthew, et al.
Publicado: (2015)

A mandibular advancement device did not affect daytime sleepiness and quality of life in obstructive sleep apnoea
por: Doff, Michiel H J
Publicado: (2015)

Autoinflation reduces middle ear effusion in children with otitis media with effusion
por: Bidarian-Moniri, Armin
Publicado: (2016)

Dihydroartemisinin–piperaquine holds promise as an option for malaria prevention in pregnancy
por: Hill, Jenny, et al.
Publicado: (2016)

Activation of WNT/β‐catenin signaling results in resistance to a dual PI3K/mTOR inhibitor in colorectal cancer cells harboring PIK3CA mutations
por: Park, Ye‐Lim, et al.
Publicado: (2018)

OxyR senses sulfane sulfur and activates the genes for its removal in Escherichia coli
por: Hou, Ningke, et al.
Publicado: (2019)

Depth distributions of bacteria for the Pseudomonas aeruginosa-infected burn wounds treated by methylene blue-mediated photodynamic therapy in rats: effects of additives to photosensitizer
por: Sarker, Roma R., et al.
Publicado: (2022)

Filgrastim associations with CAR T‐cell therapy
por: Gaut, Daria, et al.
Publicado: (2020)

OxyR is involved in coordinate regulation of expression of fimA and sod genes in Porphyromonas gingivalis
por: Wu, Jie, et al.
Publicado: (2008)

Characterization of OxyR as a Negative Transcriptional Regulator That Represses Catalase Production in Corynebacterium diphtheriae
por: Kim, Ju-Sim, et al.
Publicado: (2012)

Assisted curation of regulatory interactions and growth conditions of OxyR in E. coli K-12
por: Gama-Castro, Socorro, et al.
Publicado: (2014)

OxyR-activated expression of Dps is important for Vibrio cholerae oxidative stress resistance and pathogenesis
por: Xia, Xiaoyun, et al.
Publicado: (2017)

Resistance to oxidative stress by inner membrane protein ElaB is regulated by OxyR and RpoS
por: Guo, Yunxue, et al.
Publicado: (2019)

A phase I/II study of ivaltinostat combined with gemcitabine and erlotinib in patients with untreated locally advanced or metastatic pancreatic adenocarcinoma
por: Jo, Jung Hyun, et al.
Publicado: (2022)

Treatment Efficacy of MEDI3902 in Pseudomonas aeruginosa Bloodstream Infection and Acute Pneumonia Rabbit Models
por: Le, Hoan N., et al.
Publicado: (2019)

Anti-Biofilm Enzymes-Assisted Antibiotic Therapy against Burn Wound Infection by Pseudomonas aeruginosa
por: Zhang, Yixin, et al.
Publicado: (2023)

Cefiderocol Treatment for Patients with Multidrug- and Carbapenem-Resistant Pseudomonas aeruginosa Infections in the Compassionate Use Program
por: Satlin, Michael J., et al.
Publicado: (2023)

Liquid repellency enabled antipathogen coatings
por: Li, W., et al.
Publicado: (2021)

The Disruption of an OxyR-Like Protein Impairs Intracellular Magnetite Biomineralization in Magnetospirillum gryphiswaldense MSR-1
por: Zhang, Yunpeng, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_msvqbkr2dh2bks2vco85c40lea